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Cultivated ginseng inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice and TNF-α/IFN-γ-induced TARC activation in HaCaT cells.
Food Chem Toxicol. 2013 Jun; 56:195-203.FC

Abstract

Ginseng contains many bioactive constituents, including various ginsenosides that are believed to have anti-allergic, anti-oxidant, and immunostimulatory activities; however, its effects on atopic dermatitis (AD) remain unclear. In the current study, we hypothesized that cultivated ginseng (CG) would inhibit 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in NC/Nga mice by regulating the T helper (Th)1/Th2 balance. Also, CG inhibits TNF-α/IFN-γ-induced thymus- and activation-regulated chemokine (TARC) expression through nuclear factor-kappa B (NF-κB)-dependent signaling in HaCaT cells. CG ameliorated DNCB-induced dermatitis severity, serum levels of IgE and TARC, and mRNA expression of TARC, TNF-α, IFN-γ, IL-4, IL-5, and IL-13 in mice. Histopathological examination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells in the ears. Furthermore, CG suppressed the TNF-α/IFN-γ-induced mRNA expression of TARC in HaCaT cells. CG inhibited TNF-α/IFN-γ-induced NF-κB activation. These results suggest that CG inhibited the development of the AD-like skin symptoms by modulating Th1 and Th2 responses in the skin lesions in mice and TARC expression by suppressing TNF-α/IFN-γ-induced NF-κB activation in keratinocytes, and so may be a useful tool in the therapy of AD-like skin symptoms.

Authors+Show Affiliations

Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23454147

Citation

Choi, Jae Ho, et al. "Cultivated Ginseng Inhibits 2,4-dinitrochlorobenzene-induced Atopic Dermatitis-like Skin Lesions in NC/Nga Mice and TNF-α/IFN-γ-induced TARC Activation in HaCaT Cells." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 56, 2013, pp. 195-203.
Choi JH, Jin SW, Park BH, et al. Cultivated ginseng inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice and TNF-α/IFN-γ-induced TARC activation in HaCaT cells. Food Chem Toxicol. 2013;56:195-203.
Choi, J. H., Jin, S. W., Park, B. H., Kim, H. G., Khanal, T., Han, H. J., Hwang, Y. P., Choi, J. M., Chung, Y. C., Hwang, S. K., Jeong, T. C., & Jeong, H. G. (2013). Cultivated ginseng inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice and TNF-α/IFN-γ-induced TARC activation in HaCaT cells. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 56, 195-203. https://doi.org/10.1016/j.fct.2013.02.037
Choi JH, et al. Cultivated Ginseng Inhibits 2,4-dinitrochlorobenzene-induced Atopic Dermatitis-like Skin Lesions in NC/Nga Mice and TNF-α/IFN-γ-induced TARC Activation in HaCaT Cells. Food Chem Toxicol. 2013;56:195-203. PubMed PMID: 23454147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cultivated ginseng inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice and TNF-α/IFN-γ-induced TARC activation in HaCaT cells. AU - Choi,Jae Ho, AU - Jin,Sun Woo, AU - Park,Bong Hwan, AU - Kim,Hyung Gyun, AU - Khanal,Tilak, AU - Han,Hwa Jeong, AU - Hwang,Yong Pil, AU - Choi,Jun Min, AU - Chung,Young Chul, AU - Hwang,Sang Kyu, AU - Jeong,Tae Cheon, AU - Jeong,Hye Gwang, Y1 - 2013/02/27/ PY - 2013/01/02/received PY - 2013/02/14/revised PY - 2013/02/17/accepted PY - 2013/3/5/entrez PY - 2013/3/5/pubmed PY - 2014/1/11/medline SP - 195 EP - 203 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 56 N2 - Ginseng contains many bioactive constituents, including various ginsenosides that are believed to have anti-allergic, anti-oxidant, and immunostimulatory activities; however, its effects on atopic dermatitis (AD) remain unclear. In the current study, we hypothesized that cultivated ginseng (CG) would inhibit 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in NC/Nga mice by regulating the T helper (Th)1/Th2 balance. Also, CG inhibits TNF-α/IFN-γ-induced thymus- and activation-regulated chemokine (TARC) expression through nuclear factor-kappa B (NF-κB)-dependent signaling in HaCaT cells. CG ameliorated DNCB-induced dermatitis severity, serum levels of IgE and TARC, and mRNA expression of TARC, TNF-α, IFN-γ, IL-4, IL-5, and IL-13 in mice. Histopathological examination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells in the ears. Furthermore, CG suppressed the TNF-α/IFN-γ-induced mRNA expression of TARC in HaCaT cells. CG inhibited TNF-α/IFN-γ-induced NF-κB activation. These results suggest that CG inhibited the development of the AD-like skin symptoms by modulating Th1 and Th2 responses in the skin lesions in mice and TARC expression by suppressing TNF-α/IFN-γ-induced NF-κB activation in keratinocytes, and so may be a useful tool in the therapy of AD-like skin symptoms. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/23454147/Cultivated_ginseng_inhibits_24_dinitrochlorobenzene_induced_atopic_dermatitis_like_skin_lesions_in_NC/Nga_mice_and_TNF_α/IFN_γ_induced_TARC_activation_in_HaCaT_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(13)00146-4 DB - PRIME DP - Unbound Medicine ER -