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Clinicopathologic correlations of cranial magnetic resonance imaging of periventricular white matter.
Neurology. 1990 Jun; 40(6):911-8.Neur

Abstract

We studied clinical, imaging, and autopsy data on 7 patients who underwent magnetic resonance imaging (MRI) during life. Small periventricular zones of increased T2 signal corresponded to a periventricular cap consisting of subependymal glial accumulations, with some loss of the ependymal lining, and a surrounding pale-staining area of finely textured myelin and axons with an altered glial pattern. The fine-fiber zone is identifiable anatomically as the subcallosal fasciculus. This histologic pattern of subependymal glial accumulations and fine fibers is normal and is often associated with fibrotic small blood vessels. More extensive subcortical MRI changes corresponded, in 1 case, to multiple sclerosis, and in another to subcortical arteriosclerotic encephalopathy (Binswanger's disease) with widespread fiber loss and lacunar changes. Wallerian degeneration secondary to infarction occurred in some areas of MRI abnormality.

Authors+Show Affiliations

Department of Neurology, Massachusetts General Hospital, Boston 02114.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2345614

Citation

Leifer, D, et al. "Clinicopathologic Correlations of Cranial Magnetic Resonance Imaging of Periventricular White Matter." Neurology, vol. 40, no. 6, 1990, pp. 911-8.
Leifer D, Buonanno FS, Richardson EP. Clinicopathologic correlations of cranial magnetic resonance imaging of periventricular white matter. Neurology. 1990;40(6):911-8.
Leifer, D., Buonanno, F. S., & Richardson, E. P. (1990). Clinicopathologic correlations of cranial magnetic resonance imaging of periventricular white matter. Neurology, 40(6), 911-8.
Leifer D, Buonanno FS, Richardson EP. Clinicopathologic Correlations of Cranial Magnetic Resonance Imaging of Periventricular White Matter. Neurology. 1990;40(6):911-8. PubMed PMID: 2345614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicopathologic correlations of cranial magnetic resonance imaging of periventricular white matter. AU - Leifer,D, AU - Buonanno,F S, AU - Richardson,E P,Jr PY - 1990/6/1/pubmed PY - 2001/3/28/medline PY - 1990/6/1/entrez SP - 911 EP - 8 JF - Neurology JO - Neurology VL - 40 IS - 6 N2 - We studied clinical, imaging, and autopsy data on 7 patients who underwent magnetic resonance imaging (MRI) during life. Small periventricular zones of increased T2 signal corresponded to a periventricular cap consisting of subependymal glial accumulations, with some loss of the ependymal lining, and a surrounding pale-staining area of finely textured myelin and axons with an altered glial pattern. The fine-fiber zone is identifiable anatomically as the subcallosal fasciculus. This histologic pattern of subependymal glial accumulations and fine fibers is normal and is often associated with fibrotic small blood vessels. More extensive subcortical MRI changes corresponded, in 1 case, to multiple sclerosis, and in another to subcortical arteriosclerotic encephalopathy (Binswanger's disease) with widespread fiber loss and lacunar changes. Wallerian degeneration secondary to infarction occurred in some areas of MRI abnormality. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/2345614/Clinicopathologic_correlations_of_cranial_magnetic_resonance_imaging_of_periventricular_white_matter_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=2345614.ui DB - PRIME DP - Unbound Medicine ER -