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[About a note published in 1926 on a BCG vaccine trial in leprosy treatment].
Bull Soc Pathol Exot 2013; 106(2):126-30BS

Abstract

By 1926, two French physicians working in Indochina, R. Pons and L. Chastel, have suggested to treat leprosy by subcutaneous injections of bacillus Calmette-Guerin. This treatment appeared efficient since the lepromatous lesions quickly regressed and the Hansen bacillus disappeared from the nasal mucus. These results were quickly confirmed by other authors. They were all more appreciated than, at this time, the Chaulmoogra oil and its products, the only available drugs, were poorly efficient against the disease. Nevertheless, although not a panacea, the BCG therapy allowed to relieve these unfortunate patients until the beginning of the 1950's when an effective treatment by sulfones was at length available.

Authors+Show Affiliations

3, rue Rouget de l'Isle, 29200, Brest, France. chastelc@aol.com

Pub Type(s)

Biography
English Abstract
Historical Article
Journal Article

Language

fre

PubMed ID

23456485

Citation

Chastel, C, and A Chastel. "[About a Note Published in 1926 On a BCG Vaccine Trial in Leprosy Treatment]." Bulletin De La Societe De Pathologie Exotique (1990), vol. 106, no. 2, 2013, pp. 126-30.
Chastel C, Chastel A. [About a note published in 1926 on a BCG vaccine trial in leprosy treatment]. Bull Soc Pathol Exot. 2013;106(2):126-30.
Chastel, C., & Chastel, A. (2013). [About a note published in 1926 on a BCG vaccine trial in leprosy treatment]. Bulletin De La Societe De Pathologie Exotique (1990), 106(2), pp. 126-30. doi:10.1007/s13149-013-0280-2.
Chastel C, Chastel A. [About a Note Published in 1926 On a BCG Vaccine Trial in Leprosy Treatment]. Bull Soc Pathol Exot. 2013;106(2):126-30. PubMed PMID: 23456485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [About a note published in 1926 on a BCG vaccine trial in leprosy treatment]. AU - Chastel,C, AU - Chastel,A, Y1 - 2013/02/28/ PY - 2012/09/18/received PY - 2013/01/15/accepted PY - 2013/3/5/entrez PY - 2013/3/5/pubmed PY - 2014/1/24/medline SP - 126 EP - 30 JF - Bulletin de la Societe de pathologie exotique (1990) JO - Bull Soc Pathol Exot VL - 106 IS - 2 N2 - By 1926, two French physicians working in Indochina, R. Pons and L. Chastel, have suggested to treat leprosy by subcutaneous injections of bacillus Calmette-Guerin. This treatment appeared efficient since the lepromatous lesions quickly regressed and the Hansen bacillus disappeared from the nasal mucus. These results were quickly confirmed by other authors. They were all more appreciated than, at this time, the Chaulmoogra oil and its products, the only available drugs, were poorly efficient against the disease. Nevertheless, although not a panacea, the BCG therapy allowed to relieve these unfortunate patients until the beginning of the 1950's when an effective treatment by sulfones was at length available. SN - 1961-9049 UR - https://www.unboundmedicine.com/medline/citation/23456485/[About_a_note_published_in_1926_on_a_BCG_vaccine_trial_in_leprosy_treatment] L2 - https://link.springer.com/article/10.1007/s13149-013-0280-2 DB - PRIME DP - Unbound Medicine ER -