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Altered transfer of momentary mental states (ATOMS) as the basic unit of psychosis liability in interaction with environment and emotions.
PLoS One 2013; 8(2):e54653Plos

Abstract

Psychotic disorders are thought to represent altered neural function. However, research has failed to map diagnostic categories to alterations in neural networks. It is proposed that the basic unit of psychotic psychopathology is the moment-to-moment expression of subtle anomalous experiences of subclinical psychosis, and particularly its tendency to persist from moment-to-moment in daily life, under the influence of familial, environmental, emotional and cognitive factors.In a general population twin sample (n = 579) and in a study of patients with psychotic disorder (n = 57), their non-psychotic siblings (n = 59) and unrelated controls (n = 75), the experience sampling paradigm (ESM; repetitive, random sampling of momentary mental states and context) was applied. We analysed, in a within-person prospective design, (i) transfer of momentary anomalous experience at time point (t-1) to time point (t) in daily life, and (ii) moderating effects of negative affect, positive affect, daily stressors, IQ and childhood trauma. Additionally, (iii) familial associations between persistence of momentary anomalous experience and psychotic symptomatology were investigated. Higher level of schizotypy in the twins (but not higher level of psychotic symptoms in patients) predicted more persistence of momentary anomalous experience in daily life, both within subjects and across relatives. Persistence of momentary anomalous experience was highest in patients, intermediate in their siblings and lowest in controls. In both studies, persistence of momentary anomalous experience was moderated by higher levels of negative affect, daily stressors and childhood trauma (only in twins), and by lower levels of positive affect. The study of alterations in the moment-to-moment transfer of subtle anomalous experience of psychosis, resulting in their persistence, helps to explain why psychotic and emotional dysregulation tend to cluster in a single phenotype such as schizophrenia, and how familial and environmental risks increase the risk of expression of psychosis from, first, subtle momentary anomalous experience to, second, observable clinical symptoms.

Authors+Show Affiliations

Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23457452

Citation

Wigman, Johanna T W., et al. "Altered Transfer of Momentary Mental States (ATOMS) as the Basic Unit of Psychosis Liability in Interaction With Environment and Emotions." PloS One, vol. 8, no. 2, 2013, pp. e54653.
Wigman JT, Collip D, Wichers M, et al. Altered transfer of momentary mental states (ATOMS) as the basic unit of psychosis liability in interaction with environment and emotions. PLoS ONE. 2013;8(2):e54653.
Wigman, J. T., Collip, D., Wichers, M., Delespaul, P., Derom, C., Thiery, E., ... van Os, J. (2013). Altered transfer of momentary mental states (ATOMS) as the basic unit of psychosis liability in interaction with environment and emotions. PloS One, 8(2), pp. e54653. doi:10.1371/journal.pone.0054653.
Wigman JT, et al. Altered Transfer of Momentary Mental States (ATOMS) as the Basic Unit of Psychosis Liability in Interaction With Environment and Emotions. PLoS ONE. 2013;8(2):e54653. PubMed PMID: 23457452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered transfer of momentary mental states (ATOMS) as the basic unit of psychosis liability in interaction with environment and emotions. AU - Wigman,Johanna T W, AU - Collip,Dina, AU - Wichers,Marieke, AU - Delespaul,Philippe, AU - Derom,Catherine, AU - Thiery,Evert, AU - Vollebergh,Wilma A M, AU - Lataster,Tineke, AU - Jacobs,Nele, AU - Myin-Germeys,Inez, AU - van Os,Jim, Y1 - 2013/02/15/ PY - 2012/05/21/received PY - 2012/12/17/accepted PY - 2013/3/5/entrez PY - 2013/3/5/pubmed PY - 2013/8/27/medline SP - e54653 EP - e54653 JF - PloS one JO - PLoS ONE VL - 8 IS - 2 N2 - Psychotic disorders are thought to represent altered neural function. However, research has failed to map diagnostic categories to alterations in neural networks. It is proposed that the basic unit of psychotic psychopathology is the moment-to-moment expression of subtle anomalous experiences of subclinical psychosis, and particularly its tendency to persist from moment-to-moment in daily life, under the influence of familial, environmental, emotional and cognitive factors.In a general population twin sample (n = 579) and in a study of patients with psychotic disorder (n = 57), their non-psychotic siblings (n = 59) and unrelated controls (n = 75), the experience sampling paradigm (ESM; repetitive, random sampling of momentary mental states and context) was applied. We analysed, in a within-person prospective design, (i) transfer of momentary anomalous experience at time point (t-1) to time point (t) in daily life, and (ii) moderating effects of negative affect, positive affect, daily stressors, IQ and childhood trauma. Additionally, (iii) familial associations between persistence of momentary anomalous experience and psychotic symptomatology were investigated. Higher level of schizotypy in the twins (but not higher level of psychotic symptoms in patients) predicted more persistence of momentary anomalous experience in daily life, both within subjects and across relatives. Persistence of momentary anomalous experience was highest in patients, intermediate in their siblings and lowest in controls. In both studies, persistence of momentary anomalous experience was moderated by higher levels of negative affect, daily stressors and childhood trauma (only in twins), and by lower levels of positive affect. The study of alterations in the moment-to-moment transfer of subtle anomalous experience of psychosis, resulting in their persistence, helps to explain why psychotic and emotional dysregulation tend to cluster in a single phenotype such as schizophrenia, and how familial and environmental risks increase the risk of expression of psychosis from, first, subtle momentary anomalous experience to, second, observable clinical symptoms. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23457452/Altered_transfer_of_momentary_mental_states__ATOMS__as_the_basic_unit_of_psychosis_liability_in_interaction_with_environment_and_emotions_ L2 - http://dx.plos.org/10.1371/journal.pone.0054653 DB - PRIME DP - Unbound Medicine ER -