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Canine breed predispositions for marked hypocobalaminaemia or decreased folate concentration assessed by a laboratory survey.
J Small Anim Pract. 2013 Mar; 54(3):143-8.JS

Abstract

OBJECTIVE

The aim of this study was to determine canine breed predispositions for decreased serum folate or markedly decreased cobalamin concentrations.

METHODS

Retrospective analysis of samples from dogs that had serum folate and cobalamin concentrations measured, from 1990 to 2002 at the Comparative Gastroenterology Laboratory of Liverpool, were enrolled. A total of 13,069 samples were analysed. Those with trypsin-like immunoreactivity < 5·0 lg/L were excluded, and only breeds with at least 30 individuals tested were further analyzed. Breed predisposition was determined by calculating odds ratios and 95% confidence intervals for hypocobalaminaemia or decreased folate concentration. Significance was tested with a two-sided Fisher's exact test, and the level of statistical significance was set at P<0·05.

RESULTS

A total of 9960 dogs fulfilled the inclusion criteria. Forty breeds contained at least 30 individuals. Predispositions for hypocobalaminaemia were identified in shar peis, Staffordshire bull terriers, German shepherd dogs and mixed breeds. Predispositions for decreased folate concentration were found in golden retrievers and boxers.

CLINICAL SIGNIFICANCE

Predisposition for marked hypocobalaminaemia and decreased folate concentration differed between breeds. The shar peis had a markedly increased odds ratio for hypocobalaminaemia, as previously reported in North America, but other at-risk breeds were also identified.

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Authors+Show Affiliations

Dandrieux JR
School of Veterinary Science, University of Liverpool, Neston, Wirral.
Noble PJ
No affiliation info available
Halladay LJ
No affiliation info available
McLean L
No affiliation info available
German AJ
No affiliation info available

MeSH

AnimalsBreedingConfidence IntervalsDog DiseasesDogsFemaleFolic AcidFolic Acid DeficiencyGenetic Predisposition to DiseaseMaleOdds RatioRetrospective StudiesVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23458644

Citation

Dandrieux, J R S., et al. "Canine Breed Predispositions for Marked Hypocobalaminaemia or Decreased Folate Concentration Assessed By a Laboratory Survey." The Journal of Small Animal Practice, vol. 54, no. 3, 2013, pp. 143-8.
Dandrieux JR, Noble PJ, Halladay LJ, et al. Canine breed predispositions for marked hypocobalaminaemia or decreased folate concentration assessed by a laboratory survey. J Small Anim Pract. 2013;54(3):143-8.
Dandrieux, J. R., Noble, P. J., Halladay, L. J., McLean, L., & German, A. J. (2013). Canine breed predispositions for marked hypocobalaminaemia or decreased folate concentration assessed by a laboratory survey. The Journal of Small Animal Practice, 54(3), 143-8. https://doi.org/10.1111/jsap.12039
Dandrieux JR, et al. Canine Breed Predispositions for Marked Hypocobalaminaemia or Decreased Folate Concentration Assessed By a Laboratory Survey. J Small Anim Pract. 2013;54(3):143-8. PubMed PMID: 23458644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Canine breed predispositions for marked hypocobalaminaemia or decreased folate concentration assessed by a laboratory survey. AU - Dandrieux,J R S, AU - Noble,P-J M, AU - Halladay,L J, AU - McLean,L, AU - German,A J, PY - 2013/3/6/entrez PY - 2013/3/6/pubmed PY - 2013/5/7/medline SP - 143 EP - 8 JF - The Journal of small animal practice JO - J Small Anim Pract VL - 54 IS - 3 N2 - OBJECTIVE: The aim of this study was to determine canine breed predispositions for decreased serum folate or markedly decreased cobalamin concentrations. METHODS: Retrospective analysis of samples from dogs that had serum folate and cobalamin concentrations measured, from 1990 to 2002 at the Comparative Gastroenterology Laboratory of Liverpool, were enrolled. A total of 13,069 samples were analysed. Those with trypsin-like immunoreactivity < 5·0 lg/L were excluded, and only breeds with at least 30 individuals tested were further analyzed. Breed predisposition was determined by calculating odds ratios and 95% confidence intervals for hypocobalaminaemia or decreased folate concentration. Significance was tested with a two-sided Fisher's exact test, and the level of statistical significance was set at P<0·05. RESULTS: A total of 9960 dogs fulfilled the inclusion criteria. Forty breeds contained at least 30 individuals. Predispositions for hypocobalaminaemia were identified in shar peis, Staffordshire bull terriers, German shepherd dogs and mixed breeds. Predispositions for decreased folate concentration were found in golden retrievers and boxers. CLINICAL SIGNIFICANCE: Predisposition for marked hypocobalaminaemia and decreased folate concentration differed between breeds. The shar peis had a markedly increased odds ratio for hypocobalaminaemia, as previously reported in North America, but other at-risk breeds were also identified. SN - 1748-5827 UR - https://www.unboundmedicine.com/medline/citation/23458644/Canine_breed_predispositions_for_marked_hypocobalaminaemia_or_decreased_folate_concentration_assessed_by_a_laboratory_survey_ L2 - https://doi.org/10.1111/jsap.12039 DB - PRIME DP - Unbound Medicine ER -