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Prevailing genotypes of hepatitis C virus in Saudi Arabia: a systematic analysis of evidence.
Ann Saudi Med. 2013 Jan-Feb; 33(1):1-5.AS

Abstract

BACKGROUND AND OBJECTIVES

Although hepatitis C virus (HCV) genotype 4 has been reported to be prevalent in some countries of the Middle East, the genotype distribution in some geographical areas is not conclusive. We aimed to perform a meta-analysis on available literature on this issue in an attempt to identify or confirm the prevailing HCV genotypes in Saudi Arabia.

METHODS

We searched for reports describing genotypes in Saudi Arabia. A meta-analysis was performed on the samples in 18 studies, published between 1995 and 2011, in which HCV genotypes were identified.

RESULTS

A total of 2277 specimens from 18 studies showed that 617, 82, 119 and 1198 subjects were HCV-positive for genotypes 1, 2, 3 and 4, respectively. The meta-analyses showed that there is a great deal of heterogeneity in estimated prevalence among the studies. The highest prevalence was found in genotype HCV-4, followed by HCV-1, HCV-3, and HCV-2.

CONCLUSION

Our meta-analysei emphasizes that HCV genotype 4 is the most prevalent, followed by genotype 1. Further studies on genotype determination and subtype distribution are warranted.

Links

Publisher Full Text
ncbi.nlm.nih.gov
annsaudimed.net
PMC Free PDF

Authors+Show Affiliations

Abozaid SM
Department of Infection and Immunity, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Shoukri M
No affiliation info available
Al-Qahtani A
No affiliation info available
Al-Ahdal MN
No affiliation info available

MeSH

GenotypeHepacivirusHepatitis CHumansPrevalenceSaudi Arabia

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

23458931

Citation

Abozaid, Suhair M., et al. "Prevailing Genotypes of Hepatitis C Virus in Saudi Arabia: a Systematic Analysis of Evidence." Annals of Saudi Medicine, vol. 33, no. 1, 2013, pp. 1-5.
Abozaid SM, Shoukri M, Al-Qahtani A, et al. Prevailing genotypes of hepatitis C virus in Saudi Arabia: a systematic analysis of evidence. Ann Saudi Med. 2013;33(1):1-5.
Abozaid, S. M., Shoukri, M., Al-Qahtani, A., & Al-Ahdal, M. N. (2013). Prevailing genotypes of hepatitis C virus in Saudi Arabia: a systematic analysis of evidence. Annals of Saudi Medicine, 33(1), 1-5. https://doi.org/10.5144/0256-4947.2013.1
Abozaid SM, et al. Prevailing Genotypes of Hepatitis C Virus in Saudi Arabia: a Systematic Analysis of Evidence. Ann Saudi Med. 2013 Jan-Feb;33(1):1-5. PubMed PMID: 23458931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevailing genotypes of hepatitis C virus in Saudi Arabia: a systematic analysis of evidence. AU - Abozaid,Suhair M, AU - Shoukri,Mohamed, AU - Al-Qahtani,Ahmad, AU - Al-Ahdal,Mohammed N, PY - 2013/3/6/entrez PY - 2013/3/6/pubmed PY - 2013/9/11/medline SP - 1 EP - 5 JF - Annals of Saudi medicine JO - Ann Saudi Med VL - 33 IS - 1 N2 - BACKGROUND AND OBJECTIVES: Although hepatitis C virus (HCV) genotype 4 has been reported to be prevalent in some countries of the Middle East, the genotype distribution in some geographical areas is not conclusive. We aimed to perform a meta-analysis on available literature on this issue in an attempt to identify or confirm the prevailing HCV genotypes in Saudi Arabia. METHODS: We searched for reports describing genotypes in Saudi Arabia. A meta-analysis was performed on the samples in 18 studies, published between 1995 and 2011, in which HCV genotypes were identified. RESULTS: A total of 2277 specimens from 18 studies showed that 617, 82, 119 and 1198 subjects were HCV-positive for genotypes 1, 2, 3 and 4, respectively. The meta-analyses showed that there is a great deal of heterogeneity in estimated prevalence among the studies. The highest prevalence was found in genotype HCV-4, followed by HCV-1, HCV-3, and HCV-2. CONCLUSION: Our meta-analysei emphasizes that HCV genotype 4 is the most prevalent, followed by genotype 1. Further studies on genotype determination and subtype distribution are warranted. SN - 0975-4466 UR - https://www.unboundmedicine.com/medline/citation/23458931/Prevailing_genotypes_of_hepatitis_C_virus_in_Saudi_Arabia:_a_systematic_analysis_of_evidence_ L2 - https://www.annsaudimed.net/doi/10.5144/0256-4947.2013.1?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -