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Chronic neuropathologies of single and repetitive TBI: substrates of dementia?
Nat Rev Neurol 2013; 9(4):211-21NR

Abstract

Traumatic brain injury (TBI) has long been recognized to be a risk factor for dementia. This association has, however, only recently gained widespread attention through the increased awareness of 'chronic traumatic encephalopathy' (CTE) in athletes exposed to repetitive head injury. Originally termed 'dementia pugilistica' and linked to a career in boxing, descriptions of the neuropathological features of CTE include brain atrophy, cavum septum pellucidum, and amyloid-β, tau and TDP-43 pathologies, many of which might contribute to clinical syndromes of cognitive impairment. Similar chronic pathologies are also commonly found years after just a single moderate to severe TBI. However, little consensus currently exists on specific features of these post-TBI syndromes that might permit their confident clinical and/or pathological diagnosis. Moreover, the mechanisms contributing to neurodegeneration following TBI largely remain unknown. Here, we review the current literature and controversies in the study of chronic neuropathological changes after TBI.

Authors+Show Affiliations

Penn Center for Brain Injury and Repair and Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, 105 Hayden Hall, 3320 Smith Walk, Philadelphia, PA 19104, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

23458973

Citation

Smith, Douglas H., et al. "Chronic Neuropathologies of Single and Repetitive TBI: Substrates of Dementia?" Nature Reviews. Neurology, vol. 9, no. 4, 2013, pp. 211-21.
Smith DH, Johnson VE, Stewart W. Chronic neuropathologies of single and repetitive TBI: substrates of dementia? Nat Rev Neurol. 2013;9(4):211-21.
Smith, D. H., Johnson, V. E., & Stewart, W. (2013). Chronic neuropathologies of single and repetitive TBI: substrates of dementia? Nature Reviews. Neurology, 9(4), pp. 211-21. doi:10.1038/nrneurol.2013.29.
Smith DH, Johnson VE, Stewart W. Chronic Neuropathologies of Single and Repetitive TBI: Substrates of Dementia. Nat Rev Neurol. 2013;9(4):211-21. PubMed PMID: 23458973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic neuropathologies of single and repetitive TBI: substrates of dementia? AU - Smith,Douglas H, AU - Johnson,Victoria E, AU - Stewart,William, Y1 - 2013/03/05/ PY - 2013/3/6/entrez PY - 2013/3/6/pubmed PY - 2013/10/1/medline SP - 211 EP - 21 JF - Nature reviews. Neurology JO - Nat Rev Neurol VL - 9 IS - 4 N2 - Traumatic brain injury (TBI) has long been recognized to be a risk factor for dementia. This association has, however, only recently gained widespread attention through the increased awareness of 'chronic traumatic encephalopathy' (CTE) in athletes exposed to repetitive head injury. Originally termed 'dementia pugilistica' and linked to a career in boxing, descriptions of the neuropathological features of CTE include brain atrophy, cavum septum pellucidum, and amyloid-β, tau and TDP-43 pathologies, many of which might contribute to clinical syndromes of cognitive impairment. Similar chronic pathologies are also commonly found years after just a single moderate to severe TBI. However, little consensus currently exists on specific features of these post-TBI syndromes that might permit their confident clinical and/or pathological diagnosis. Moreover, the mechanisms contributing to neurodegeneration following TBI largely remain unknown. Here, we review the current literature and controversies in the study of chronic neuropathological changes after TBI. SN - 1759-4766 UR - https://www.unboundmedicine.com/medline/citation/23458973/Chronic_neuropathologies_of_single_and_repetitive_TBI:_substrates_of_dementia L2 - http://dx.doi.org/10.1038/nrneurol.2013.29 DB - PRIME DP - Unbound Medicine ER -