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Current evidence for the clinical use of long-chain polyunsaturated n-3 fatty acids to prevent age-related cognitive decline and Alzheimer's disease.
J Nutr Health Aging. 2013 Mar; 17(3):240-51.JN

Abstract

An NIH State of the Science Conference panel concluded in 2010 that insufficient evidence is available to recommend the use of any primary prevention therapy for Alzheimer's disease or cognitive decline with age. Despite the insufficient evidence, candidate therapies with varying levels of evidence for safety and efficacy are taken by the public and discussed in the media. One example is the long-chain n-3 (omega-3) polyunsaturated fatty acids (n-3 LC-PUFA), DHA and EPA, found in some fish and dietary supplements. With this report, we seek to provide a practical overview and rating of the level and type of available evidence that n-3 LC-PUFA supplements are safe and protective against cognitive aging and Alzheimer's disease, with additional discussion of the evidence for effects on quality of life, vascular aging, and the rate of aging. We discuss available sources, dose, bioavailability, and variables that may impact the response to n-3 LC-PUFA treatment such as baseline n-3 LC-PUFA status, APOE ε4 genotype, depression, and background diet. Lastly, we list ongoing clinical trials and propose next research steps to validate these fatty acids for primary prevention of cognitive aging and dementia. Of particular relevance, epidemiology indicates a higher risk of cognitive decline in people in the lower quartile of n-3 LC-PUFA intake or blood levels but these populations have not been specifically targeted by RCTs.

Authors+Show Affiliations

Alzheimer's Drug Discovery Foundation, USA. pdacks@alzdiscovery.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23459977

Citation

Dacks, P A., et al. "Current Evidence for the Clinical Use of Long-chain Polyunsaturated N-3 Fatty Acids to Prevent Age-related Cognitive Decline and Alzheimer's Disease." The Journal of Nutrition, Health & Aging, vol. 17, no. 3, 2013, pp. 240-51.
Dacks PA, Shineman DW, Fillit HM. Current evidence for the clinical use of long-chain polyunsaturated n-3 fatty acids to prevent age-related cognitive decline and Alzheimer's disease. J Nutr Health Aging. 2013;17(3):240-51.
Dacks, P. A., Shineman, D. W., & Fillit, H. M. (2013). Current evidence for the clinical use of long-chain polyunsaturated n-3 fatty acids to prevent age-related cognitive decline and Alzheimer's disease. The Journal of Nutrition, Health & Aging, 17(3), 240-51. https://doi.org/10.1007/s12603-012-0431-3
Dacks PA, Shineman DW, Fillit HM. Current Evidence for the Clinical Use of Long-chain Polyunsaturated N-3 Fatty Acids to Prevent Age-related Cognitive Decline and Alzheimer's Disease. J Nutr Health Aging. 2013;17(3):240-51. PubMed PMID: 23459977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current evidence for the clinical use of long-chain polyunsaturated n-3 fatty acids to prevent age-related cognitive decline and Alzheimer's disease. AU - Dacks,P A, AU - Shineman,D W, AU - Fillit,H M, PY - 2013/3/6/entrez PY - 2013/3/6/pubmed PY - 2013/9/17/medline SP - 240 EP - 51 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 17 IS - 3 N2 - An NIH State of the Science Conference panel concluded in 2010 that insufficient evidence is available to recommend the use of any primary prevention therapy for Alzheimer's disease or cognitive decline with age. Despite the insufficient evidence, candidate therapies with varying levels of evidence for safety and efficacy are taken by the public and discussed in the media. One example is the long-chain n-3 (omega-3) polyunsaturated fatty acids (n-3 LC-PUFA), DHA and EPA, found in some fish and dietary supplements. With this report, we seek to provide a practical overview and rating of the level and type of available evidence that n-3 LC-PUFA supplements are safe and protective against cognitive aging and Alzheimer's disease, with additional discussion of the evidence for effects on quality of life, vascular aging, and the rate of aging. We discuss available sources, dose, bioavailability, and variables that may impact the response to n-3 LC-PUFA treatment such as baseline n-3 LC-PUFA status, APOE ε4 genotype, depression, and background diet. Lastly, we list ongoing clinical trials and propose next research steps to validate these fatty acids for primary prevention of cognitive aging and dementia. Of particular relevance, epidemiology indicates a higher risk of cognitive decline in people in the lower quartile of n-3 LC-PUFA intake or blood levels but these populations have not been specifically targeted by RCTs. SN - 1760-4788 UR - https://www.unboundmedicine.com/medline/citation/23459977/Current_evidence_for_the_clinical_use_of_long_chain_polyunsaturated_n_3_fatty_acids_to_prevent_age_related_cognitive_decline_and_Alzheimer's_disease_ L2 - https://medlineplus.gov/olderadulthealth.html DB - PRIME DP - Unbound Medicine ER -