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A review of multidomain interventions to support healthy cognitive ageing.
J Nutr Health Aging. 2013 Mar; 17(3):252-7.JN

Abstract

OBJECTIVE

The risk for cognitive decline and for developing Alzheimer's disease increases with age. The aetiology is assumed to be of multi-factorial origin, and treatment opportunities are lacking. Despite the multi-factorial origin, many intervention studies focused on single factors to influence cognitive health with inconsistent findings. In this view, more and more intervention studies aim to intervene on multiple factors simultaneously to affect or slow down cognitive decline. The purpose of this paper is to give an overview of these multidomain intervention trials.

METHODS

We conducted a non-systematic literature search in Medline, Scopus, Cochrane Library, and clinical trials databases up to October 2011 to review multidomain interventions that investigated effects of combined lifestyle-related factors on cognitive decline and the progression of dementia.

RESULTS

Interest in multidomain interventions increased over the past years. We identified six completed and published trials and eight ongoing or not yet published studies that investigated effects on cognitive outcomes. First completed trials yielded promising results for the combination of exercise and mental training and diet and behavioural weight management. Results of ongoing multidomain trials are awaited.

CONCLUSIONS

Some evidence suggests that strategies which target multiple factors simultaneously may prove more effective than those focusing on a single mechanism or domain. Larger high-quality randomized controlled trials are required to systematically investigate the cognitive effect of programs comprising physical and mental activity as well as nutritional aspects.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Schneider N
Nestec Ltd., Nestlé Research Center Lausanne, Switzerland.
Yvon C
No affiliation info available

MeSH

AgedAged, 80 and overAgingAlzheimer DiseaseCognitionCognition DisordersDietExerciseHumansLife StyleRandomized Controlled Trials as TopicRisk Factors

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23459978

Citation

Schneider, N, and C Yvon. "A Review of Multidomain Interventions to Support Healthy Cognitive Ageing." The Journal of Nutrition, Health & Aging, vol. 17, no. 3, 2013, pp. 252-7.
Schneider N, Yvon C. A review of multidomain interventions to support healthy cognitive ageing. J Nutr Health Aging. 2013;17(3):252-7.
Schneider, N., & Yvon, C. (2013). A review of multidomain interventions to support healthy cognitive ageing. The Journal of Nutrition, Health & Aging, 17(3), 252-7. https://doi.org/10.1007/s12603-012-0402-8
Schneider N, Yvon C. A Review of Multidomain Interventions to Support Healthy Cognitive Ageing. J Nutr Health Aging. 2013;17(3):252-7. PubMed PMID: 23459978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A review of multidomain interventions to support healthy cognitive ageing. AU - Schneider,N, AU - Yvon,C, PY - 2013/3/6/entrez PY - 2013/3/6/pubmed PY - 2013/9/17/medline SP - 252 EP - 7 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 17 IS - 3 N2 - OBJECTIVE: The risk for cognitive decline and for developing Alzheimer's disease increases with age. The aetiology is assumed to be of multi-factorial origin, and treatment opportunities are lacking. Despite the multi-factorial origin, many intervention studies focused on single factors to influence cognitive health with inconsistent findings. In this view, more and more intervention studies aim to intervene on multiple factors simultaneously to affect or slow down cognitive decline. The purpose of this paper is to give an overview of these multidomain intervention trials. METHODS: We conducted a non-systematic literature search in Medline, Scopus, Cochrane Library, and clinical trials databases up to October 2011 to review multidomain interventions that investigated effects of combined lifestyle-related factors on cognitive decline and the progression of dementia. RESULTS: Interest in multidomain interventions increased over the past years. We identified six completed and published trials and eight ongoing or not yet published studies that investigated effects on cognitive outcomes. First completed trials yielded promising results for the combination of exercise and mental training and diet and behavioural weight management. Results of ongoing multidomain trials are awaited. CONCLUSIONS: Some evidence suggests that strategies which target multiple factors simultaneously may prove more effective than those focusing on a single mechanism or domain. Larger high-quality randomized controlled trials are required to systematically investigate the cognitive effect of programs comprising physical and mental activity as well as nutritional aspects. SN - 1760-4788 UR - https://www.unboundmedicine.com/medline/citation/23459978/A_review_of_multidomain_interventions_to_support_healthy_cognitive_ageing_ L2 - https://doi.org/10.1007/s12603-012-0402-8 DB - PRIME DP - Unbound Medicine ER -