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Microbiological transformation of flavone and isoflavone.
Xenobiotica. 1990 Apr; 20(4):363-73.X

Abstract

1. Flavone and isoflavone were subjected to microbial transformation studies. Screening with 80 fungal species showed that flavone was transformed by a large number of microorganisms and in higher yields than isoflavone. 2. Large-scale fermentations of flavone followed by isolation and characterization of metabolites using spectroscopic analysis showed the formation of 4'-hydroxyflavone, 3',4'-dihydroxyflavone and two cleavage products identified as o-hydroxyphenyl-hydroxymethyl ketone and 1-(o-hydroxyphenyl)-1,2-ethanediol. However, fermentation of isoflavone gave only 4'-hydroxyisoflavone and 3',4'-dihydroxyisoflavone.

Authors+Show Affiliations

Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2346033

Citation

Ibrahim, A R., and Y J. Abul-Hajj. "Microbiological Transformation of Flavone and Isoflavone." Xenobiotica; the Fate of Foreign Compounds in Biological Systems, vol. 20, no. 4, 1990, pp. 363-73.
Ibrahim AR, Abul-Hajj YJ. Microbiological transformation of flavone and isoflavone. Xenobiotica. 1990;20(4):363-73.
Ibrahim, A. R., & Abul-Hajj, Y. J. (1990). Microbiological transformation of flavone and isoflavone. Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 20(4), 363-73.
Ibrahim AR, Abul-Hajj YJ. Microbiological Transformation of Flavone and Isoflavone. Xenobiotica. 1990;20(4):363-73. PubMed PMID: 2346033.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbiological transformation of flavone and isoflavone. AU - Ibrahim,A R, AU - Abul-Hajj,Y J, PY - 1990/4/1/pubmed PY - 1990/4/1/medline PY - 1990/4/1/entrez SP - 363 EP - 73 JF - Xenobiotica; the fate of foreign compounds in biological systems JO - Xenobiotica VL - 20 IS - 4 N2 - 1. Flavone and isoflavone were subjected to microbial transformation studies. Screening with 80 fungal species showed that flavone was transformed by a large number of microorganisms and in higher yields than isoflavone. 2. Large-scale fermentations of flavone followed by isolation and characterization of metabolites using spectroscopic analysis showed the formation of 4'-hydroxyflavone, 3',4'-dihydroxyflavone and two cleavage products identified as o-hydroxyphenyl-hydroxymethyl ketone and 1-(o-hydroxyphenyl)-1,2-ethanediol. However, fermentation of isoflavone gave only 4'-hydroxyisoflavone and 3',4'-dihydroxyisoflavone. SN - 0049-8254 UR - https://www.unboundmedicine.com/medline/citation/2346033/Microbiological_transformation_of_flavone_and_isoflavone_ L2 - http://www.tandfonline.com/doi/full/10.3109/00498259009046853 DB - PRIME DP - Unbound Medicine ER -