Prime

Type your tag names separated by a space and hit enter

Weight status of children with sickle cell disease.

Abstract

OBJECTIVE

Historically, many children and adolescents with sickle cell disease (SCD) were underweight. Treatment advances like hydroxyurea have been associated with improved growth. We hypothesized that increased hemoglobin (Hb) levels would be associated with increased weight status of children with SCD.

METHODS

Investigators at 6 institutions conducted a retrospective chart review of all patients aged 2 to 19 years of age for the calendar years 2007-2009. Height, weight, baseline Hb levels, demographic information, and select comorbidities were recorded from the most recent clinic visit. Overweight and obesity were defined as ≥85th and ≥95th BMI percentiles for age and gender, respectively, and underweight was defined as <5th BMI percentile.

RESULTS

Data were collected on 675 children and adolescents in 3 New England states. In this sample, 22.4% were overweight or obese, whereas only 6.7% were underweight. Overweight or obese status was associated with sickle genotypes other than Hb SS or Hb Sβ(0) disease, and were associated with higher baseline Hb levels. Underweight individuals were more likely to be male, older, and have had at least 1 SCD-related complication. After adjusting for demographic factors, any SCD-related complication, SCD-directed treatments, and obesity-related conditions, there was a 36% increased odds of overweight/obesity for each 1 g/dL increase in baseline Hb levels.

CONCLUSIONS

Nearly one-quarter of children and adolescents with SCD in New England are overweight or obese. Longitudinal studies are needed to determine the impact of elevated BMI on the morbidity and mortality of both children and adults with SCD.

Links

  • FREE Publisher Full Text
  • Authors

    , , , , , ,

    Source

    Pediatrics 131:4 2013 Apr pg e1168-73

    MeSH

    Adolescent
    Age Factors
    Anemia, Sickle Cell
    Biological Markers
    Body Mass Index
    Child
    Child, Preschool
    Female
    Genotype
    Hemoglobins
    Humans
    Logistic Models
    Male
    Multivariate Analysis
    New England
    Obesity
    Overweight
    Prevalence
    Retrospective Studies
    Risk Factors
    Sex Factors
    Thinness
    Young Adult

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23460681

    Citation

    TY - JOUR T1 - Weight status of children with sickle cell disease. AU - Chawla,Anjulika, AU - Sprinz,Philippa G, AU - Welch,Jennifer, AU - Heeney,Matthew, AU - Usmani,Naheed, AU - Pashankar,Farzana, AU - Kavanagh,Patricia, Y1 - 2013/03/04/ PY - 2013/3/4/aheadofprint PY - 2013/3/6/entrez PY - 2013/3/6/pubmed PY - 2013/5/22/medline SP - e1168 EP - 73 JF - Pediatrics JO - Pediatrics VL - 131 IS - 4 N2 - OBJECTIVE: Historically, many children and adolescents with sickle cell disease (SCD) were underweight. Treatment advances like hydroxyurea have been associated with improved growth. We hypothesized that increased hemoglobin (Hb) levels would be associated with increased weight status of children with SCD. METHODS: Investigators at 6 institutions conducted a retrospective chart review of all patients aged 2 to 19 years of age for the calendar years 2007-2009. Height, weight, baseline Hb levels, demographic information, and select comorbidities were recorded from the most recent clinic visit. Overweight and obesity were defined as ≥85th and ≥95th BMI percentiles for age and gender, respectively, and underweight was defined as <5th BMI percentile. RESULTS: Data were collected on 675 children and adolescents in 3 New England states. In this sample, 22.4% were overweight or obese, whereas only 6.7% were underweight. Overweight or obese status was associated with sickle genotypes other than Hb SS or Hb Sβ(0) disease, and were associated with higher baseline Hb levels. Underweight individuals were more likely to be male, older, and have had at least 1 SCD-related complication. After adjusting for demographic factors, any SCD-related complication, SCD-directed treatments, and obesity-related conditions, there was a 36% increased odds of overweight/obesity for each 1 g/dL increase in baseline Hb levels. CONCLUSIONS: Nearly one-quarter of children and adolescents with SCD in New England are overweight or obese. Longitudinal studies are needed to determine the impact of elevated BMI on the morbidity and mortality of both children and adults with SCD. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/23460681/full_citation L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&amp;pmid=23460681 ER -