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Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis.
PLoS One 2013; 8(2):e57261Plos

Abstract

BACKGROUND

Past evidence has suggested a role of artificial sweeteners in allergic disease; yet, the evidence has been inconsistent and unclear.

OBJECTIVE

To examine relation of intake of artificially-sweetened beverages during pregnancy with child asthma and allergic rhinitis at 18 months and 7 years.

METHODS

We analyzed data from 60,466 women enrolled during pregnancy in the prospective longitudinal Danish National Birth Cohort between 1996 and 2003. At the 25th week of gestation we administered a validated Food Frequency Questionnaire which asked in detail about intake of artificially-sweetened soft drinks. At 18 months, we evaluated child asthma using interview data. We also assessed asthma and allergic rhinitis through a questionnaire at age 7 and by using national registries. Current asthma was defined as self-reported asthma diagnosis and wheeze in the past 12 months. We examined the relation between intake of artificially-sweetened soft drinks and child allergic disease outcomes and present here odds ratios with 95% CI comparing daily vs. no intake.

RESULTS

At 18 months, we found that mothers who consumed more artificially-sweetened non-carbonated soft drinks were 1.23 (95% CI: 1.13, 1.33) times more likely to report a child asthma diagnosis compared to non-consumers. Similar results were found for child wheeze. Consumers of artificially-sweetened carbonated drinks were more likely to have a child asthma diagnosis in the patient (1.30, 95% CI: 1.01, 1.66) and medication (1.13, 95% CI: 0.98, 1.29) registry, as well as self-reported allergic rhinitis (1.31, 95% CI: 0.98, 1.74) during the first 7 years of follow-up. We found no associations for sugar-sweetened soft drinks.

CONCLUSION

Carbonated artificially-sweetened soft drinks were associated with registry-based asthma and self-reported allergic rhinitis, while early childhood outcomes were related to non-carbonated soft drinks. These results suggest that consumption of artificially-sweetened soft drinks during pregnancy may play a role in offspring allergic disease development.

Authors+Show Affiliations

Centre for Fetal Programming, Department of Epidemiology, Statens Serum Institut, Copenhagen, Denmark. emaslova@post.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23460835

Citation

Maslova, Ekaterina, et al. "Consumption of Artificially-sweetened Soft Drinks in Pregnancy and Risk of Child Asthma and Allergic Rhinitis." PloS One, vol. 8, no. 2, 2013, pp. e57261.
Maslova E, Strøm M, Olsen SF, et al. Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis. PLoS ONE. 2013;8(2):e57261.
Maslova, E., Strøm, M., Olsen, S. F., & Halldorsson, T. I. (2013). Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis. PloS One, 8(2), pp. e57261. doi:10.1371/journal.pone.0057261.
Maslova E, et al. Consumption of Artificially-sweetened Soft Drinks in Pregnancy and Risk of Child Asthma and Allergic Rhinitis. PLoS ONE. 2013;8(2):e57261. PubMed PMID: 23460835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis. AU - Maslova,Ekaterina, AU - Strøm,Marin, AU - Olsen,Sjurdur F, AU - Halldorsson,Thorhallur I, Y1 - 2013/02/27/ PY - 2012/10/12/received PY - 2013/01/18/accepted PY - 2013/3/6/entrez PY - 2013/3/6/pubmed PY - 2013/9/4/medline SP - e57261 EP - e57261 JF - PloS one JO - PLoS ONE VL - 8 IS - 2 N2 - BACKGROUND: Past evidence has suggested a role of artificial sweeteners in allergic disease; yet, the evidence has been inconsistent and unclear. OBJECTIVE: To examine relation of intake of artificially-sweetened beverages during pregnancy with child asthma and allergic rhinitis at 18 months and 7 years. METHODS: We analyzed data from 60,466 women enrolled during pregnancy in the prospective longitudinal Danish National Birth Cohort between 1996 and 2003. At the 25th week of gestation we administered a validated Food Frequency Questionnaire which asked in detail about intake of artificially-sweetened soft drinks. At 18 months, we evaluated child asthma using interview data. We also assessed asthma and allergic rhinitis through a questionnaire at age 7 and by using national registries. Current asthma was defined as self-reported asthma diagnosis and wheeze in the past 12 months. We examined the relation between intake of artificially-sweetened soft drinks and child allergic disease outcomes and present here odds ratios with 95% CI comparing daily vs. no intake. RESULTS: At 18 months, we found that mothers who consumed more artificially-sweetened non-carbonated soft drinks were 1.23 (95% CI: 1.13, 1.33) times more likely to report a child asthma diagnosis compared to non-consumers. Similar results were found for child wheeze. Consumers of artificially-sweetened carbonated drinks were more likely to have a child asthma diagnosis in the patient (1.30, 95% CI: 1.01, 1.66) and medication (1.13, 95% CI: 0.98, 1.29) registry, as well as self-reported allergic rhinitis (1.31, 95% CI: 0.98, 1.74) during the first 7 years of follow-up. We found no associations for sugar-sweetened soft drinks. CONCLUSION: Carbonated artificially-sweetened soft drinks were associated with registry-based asthma and self-reported allergic rhinitis, while early childhood outcomes were related to non-carbonated soft drinks. These results suggest that consumption of artificially-sweetened soft drinks during pregnancy may play a role in offspring allergic disease development. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23460835/Consumption_of_artificially_sweetened_soft_drinks_in_pregnancy_and_risk_of_child_asthma_and_allergic_rhinitis_ L2 - http://dx.plos.org/10.1371/journal.pone.0057261 DB - PRIME DP - Unbound Medicine ER -