Tags

Type your tag names separated by a space and hit enter

Association between TPH2 gene polymorphisms and attention deficit hyperactivity disorder in Korean children.
Genet Test Mol Biomarkers 2013; 17(4):301-6GT

Abstract

Attention deficit hyperactivity disorder (ADHD) is a common disorder of the school-age population. ADHD is a familial disorder and genetic studies estimate heritability at 80%-90%. The aim of the present study was to investigate the association between the genetic type and alleles for the TPH2 gene in Korean children with ADHD. The sample consisted of 142 ADHD children and 139 control children. We diagnosed ADHD according to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition). ADHD symptoms were evaluated with Conners' Parent Rating Scales and Dupaul Parent ADHD Rating Scales. Blood samples were taken from the 281 subjects, DNA was extracted from blood lymphocytes, and polymerase chain reaction was performed for TPH2 polymorphism. Alleles and genotype frequencies were compared using the chi-square test. We compared the allele and genotype frequencies of TPH2 gene polymorphism in the ADHD and control groups. This study showed that there was a significant correlation among the frequencies of the rs11179027 (odd ratio [OR]=2.12, 95% confidence interval [CI]=1.13-3.97, p=0.020) and rs1843809 (OR=0.48, 95% CI=0.24-0.97, p=0.040) of alleles of TPH2, but the final conclusions are not definite. Follow-up studies with larger patient or pure subgroups are expected. These results suggested that TPH2 might be related to ADHD symptoms.

Authors+Show Affiliations

Department of Psychiatry, College of Medicine, Chonbuk National University, Chonju, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23461725

Citation

Park, Tae Won, et al. "Association Between TPH2 Gene Polymorphisms and Attention Deficit Hyperactivity Disorder in Korean Children." Genetic Testing and Molecular Biomarkers, vol. 17, no. 4, 2013, pp. 301-6.
Park TW, Park YH, Kwon HJ, et al. Association between TPH2 gene polymorphisms and attention deficit hyperactivity disorder in Korean children. Genet Test Mol Biomarkers. 2013;17(4):301-6.
Park, T. W., Park, Y. H., Kwon, H. J., & Lim, M. H. (2013). Association between TPH2 gene polymorphisms and attention deficit hyperactivity disorder in Korean children. Genetic Testing and Molecular Biomarkers, 17(4), pp. 301-6. doi:10.1089/gtmb.2012.0376.
Park TW, et al. Association Between TPH2 Gene Polymorphisms and Attention Deficit Hyperactivity Disorder in Korean Children. Genet Test Mol Biomarkers. 2013;17(4):301-6. PubMed PMID: 23461725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between TPH2 gene polymorphisms and attention deficit hyperactivity disorder in Korean children. AU - Park,Tae Won, AU - Park,Young Hyun, AU - Kwon,Ho Jang, AU - Lim,Myung Ho, Y1 - 2013/03/05/ PY - 2013/3/7/entrez PY - 2013/3/7/pubmed PY - 2013/9/17/medline SP - 301 EP - 6 JF - Genetic testing and molecular biomarkers JO - Genet Test Mol Biomarkers VL - 17 IS - 4 N2 - Attention deficit hyperactivity disorder (ADHD) is a common disorder of the school-age population. ADHD is a familial disorder and genetic studies estimate heritability at 80%-90%. The aim of the present study was to investigate the association between the genetic type and alleles for the TPH2 gene in Korean children with ADHD. The sample consisted of 142 ADHD children and 139 control children. We diagnosed ADHD according to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition). ADHD symptoms were evaluated with Conners' Parent Rating Scales and Dupaul Parent ADHD Rating Scales. Blood samples were taken from the 281 subjects, DNA was extracted from blood lymphocytes, and polymerase chain reaction was performed for TPH2 polymorphism. Alleles and genotype frequencies were compared using the chi-square test. We compared the allele and genotype frequencies of TPH2 gene polymorphism in the ADHD and control groups. This study showed that there was a significant correlation among the frequencies of the rs11179027 (odd ratio [OR]=2.12, 95% confidence interval [CI]=1.13-3.97, p=0.020) and rs1843809 (OR=0.48, 95% CI=0.24-0.97, p=0.040) of alleles of TPH2, but the final conclusions are not definite. Follow-up studies with larger patient or pure subgroups are expected. These results suggested that TPH2 might be related to ADHD symptoms. SN - 1945-0257 UR - https://www.unboundmedicine.com/medline/citation/23461725/Association_between_TPH2_gene_polymorphisms_and_attention_deficit_hyperactivity_disorder_in_Korean_children_ L2 - https://www.liebertpub.com/doi/full/10.1089/gtmb.2012.0376?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -