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Diastolic dysfunction measured by tissue Doppler imaging in children with end-stage renal disease: a report of the RICH-Q study.
Cardiol Young. 2014 Apr; 24(2):236-44.CY

Abstract

INTRODUCTION

Early detection of cardiovascular disease in children with end-stage renal disease is essential in order to prevent cardiovascular morbidity and mortality in early adulthood. Tissue Doppler imaging has shown to be a promising method to detect and quantify subtle abnormalities in diastolic function. We therefore compared assessment of diastolic function by conventional echocardiography and tissue Doppler imaging.

METHODS

We performed conventional echocardiography and tissue Doppler imaging in 38 children with end-stage renal disease and 76 healthy controls. We compared outcomes on parameters related to diastolic function (E/a ratio for conventional echocardiography and E/E' ratio for tissue Doppler imaging) for both groups using multiple linear regression analysis. Diastolic dysfunction was defined as E/a ratio <1 or E/E' ratio > 95th percentile for age. To assess the intra-observer reproducibility, the coefficient of variation was calculated.

RESULTS

Children with end-stage renal disease had on average a lower E/a ratio (p = 0.004) and a higher mitral and septal E/E' ratio (both p < 0.001) compared with controls. In all, two children with end-stage renal disease (5%) had diastolic dysfunction according to the E/a ratio, 11 according to the mitral E/E' ratio (29%), and 16 according to the septal E/E' ratio (42%) compared with none of the controls (p = 0.109, p < 0.001, and p < 0.001, respectively). The coefficients of variation of the mitral (7%) and septal E/E' ratio (4%) were smaller than the coefficient of variation of the E/a ratio (11%).

CONCLUSIONS

Tissue Doppler imaging is a more sensitive and reliable method to detect diastolic dysfunction than conventional E/a ratio in children with end-stage renal disease.

Authors+Show Affiliations

1 Department of Paediatric Nephrology, Emma Children's Hospital AMC Amsterdam, The Netherlands.2 Department of Paediatric Cardiology, Emma Children's Hospital AMC Amsterdam, The Netherlands.3 Department of Paediatric Clinical Epidemiology, Emma Children's Hospital AMC Amsterdam, The Netherlands.1 Department of Paediatric Nephrology, Emma Children's Hospital AMC Amsterdam, The Netherlands.4 Department of Paediatric Nephrology, University Hospital Leuven, Belgium.5 Department of Paediatric Cardiology, University Hospital Leuven, Belgium.2 Department of Paediatric Cardiology, Emma Children's Hospital AMC Amsterdam, The Netherlands.1 Department of Paediatric Nephrology, Emma Children's Hospital AMC Amsterdam, The Netherlands.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23462068

Citation

Schoenmaker, Nikki J., et al. "Diastolic Dysfunction Measured By Tissue Doppler Imaging in Children With End-stage Renal Disease: a Report of the RICH-Q Study." Cardiology in the Young, vol. 24, no. 2, 2014, pp. 236-44.
Schoenmaker NJ, Kuipers IM, van der Lee JH, et al. Diastolic dysfunction measured by tissue Doppler imaging in children with end-stage renal disease: a report of the RICH-Q study. Cardiol Young. 2014;24(2):236-44.
Schoenmaker, N. J., Kuipers, I. M., van der Lee, J. H., Tromp, W. F., van Dyck, M., Gewillig, M., Blom, N. A., & Groothoff, J. W. (2014). Diastolic dysfunction measured by tissue Doppler imaging in children with end-stage renal disease: a report of the RICH-Q study. Cardiology in the Young, 24(2), 236-44. https://doi.org/10.1017/S1047951113000188
Schoenmaker NJ, et al. Diastolic Dysfunction Measured By Tissue Doppler Imaging in Children With End-stage Renal Disease: a Report of the RICH-Q Study. Cardiol Young. 2014;24(2):236-44. PubMed PMID: 23462068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diastolic dysfunction measured by tissue Doppler imaging in children with end-stage renal disease: a report of the RICH-Q study. AU - Schoenmaker,Nikki J, AU - Kuipers,Irene M, AU - van der Lee,Johanna H, AU - Tromp,Wilma F, AU - van Dyck,Maria, AU - Gewillig,Marc, AU - Blom,Nico A, AU - Groothoff,Jaap W, Y1 - 2013/03/05/ PY - 2013/3/7/entrez PY - 2013/3/7/pubmed PY - 2014/12/15/medline SP - 236 EP - 44 JF - Cardiology in the young JO - Cardiol Young VL - 24 IS - 2 N2 - INTRODUCTION: Early detection of cardiovascular disease in children with end-stage renal disease is essential in order to prevent cardiovascular morbidity and mortality in early adulthood. Tissue Doppler imaging has shown to be a promising method to detect and quantify subtle abnormalities in diastolic function. We therefore compared assessment of diastolic function by conventional echocardiography and tissue Doppler imaging. METHODS: We performed conventional echocardiography and tissue Doppler imaging in 38 children with end-stage renal disease and 76 healthy controls. We compared outcomes on parameters related to diastolic function (E/a ratio for conventional echocardiography and E/E' ratio for tissue Doppler imaging) for both groups using multiple linear regression analysis. Diastolic dysfunction was defined as E/a ratio <1 or E/E' ratio > 95th percentile for age. To assess the intra-observer reproducibility, the coefficient of variation was calculated. RESULTS: Children with end-stage renal disease had on average a lower E/a ratio (p = 0.004) and a higher mitral and septal E/E' ratio (both p < 0.001) compared with controls. In all, two children with end-stage renal disease (5%) had diastolic dysfunction according to the E/a ratio, 11 according to the mitral E/E' ratio (29%), and 16 according to the septal E/E' ratio (42%) compared with none of the controls (p = 0.109, p < 0.001, and p < 0.001, respectively). The coefficients of variation of the mitral (7%) and septal E/E' ratio (4%) were smaller than the coefficient of variation of the E/a ratio (11%). CONCLUSIONS: Tissue Doppler imaging is a more sensitive and reliable method to detect diastolic dysfunction than conventional E/a ratio in children with end-stage renal disease. SN - 1467-1107 UR - https://www.unboundmedicine.com/medline/citation/23462068/Diastolic_dysfunction_measured_by_tissue_Doppler_imaging_in_children_with_end_stage_renal_disease:_a_report_of_the_RICH_Q_study_ L2 - https://www.cambridge.org/core/product/identifier/S1047951113000188/type/journal_article DB - PRIME DP - Unbound Medicine ER -