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The beneficial role of thiamine in Parkinson disease.

Abstract

Parkinson disease (PD) is the second most common form of neurodegeneration among elderly individuals. PD is clinically characterized by tremors, rigidity, slowness of movement, and postural imbalance. In this paper, we review the evidence for an association between PD and thiamine. Interestingly, a significant association has been demonstrated between PD and low levels of serum thiamine, and thiamine supplements appear to have beneficial clinical effects against PD. Multiple studies have evaluated the connection between thiamine and PD pathology, and candidate pathways involve the transcription factor Sp1, p53, Bcl-2, caspase-3, tyrosine hydroxylase, glycogen synthase kinase-3β, vascular endothelial growth factor, advanced glycation end products, nuclear factor kappa B, mitogen-activated protein kinase, and the reduced form of nicotinamide adenine dinucleotide phosphate. Thus, a review of the literature suggests that thiamine plays a role in PD, although further investigation into the effects of thiamine in PD is needed.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Vietnamese American Medical Research Foundation, Westminster, CA 92683, USA.

    Source

    CNS neuroscience & therapeutics 19:7 2013 Jul pg 461-8

    MeSH

    Animals
    Humans
    Parkinson Disease
    Signal Transduction
    Thiamine
    Vitamins

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    23462281

    Citation

    TY - JOUR T1 - The beneficial role of thiamine in Parkinson disease. AU - Luong,Khanh V Q, AU - Nguyễn,Lan T H, Y1 - 2013/03/06/ PY - 2012/11/30/received PY - 2013/01/24/revised PY - 2013/01/26/accepted PY - 2013/3/7/entrez PY - 2013/3/7/pubmed PY - 2014/1/21/medline SP - 461 EP - 8 JF - CNS neuroscience & therapeutics JO - CNS Neurosci Ther VL - 19 IS - 7 N2 - Parkinson disease (PD) is the second most common form of neurodegeneration among elderly individuals. PD is clinically characterized by tremors, rigidity, slowness of movement, and postural imbalance. In this paper, we review the evidence for an association between PD and thiamine. Interestingly, a significant association has been demonstrated between PD and low levels of serum thiamine, and thiamine supplements appear to have beneficial clinical effects against PD. Multiple studies have evaluated the connection between thiamine and PD pathology, and candidate pathways involve the transcription factor Sp1, p53, Bcl-2, caspase-3, tyrosine hydroxylase, glycogen synthase kinase-3β, vascular endothelial growth factor, advanced glycation end products, nuclear factor kappa B, mitogen-activated protein kinase, and the reduced form of nicotinamide adenine dinucleotide phosphate. Thus, a review of the literature suggests that thiamine plays a role in PD, although further investigation into the effects of thiamine in PD is needed. SN - 1755-5949 UR - https://www.unboundmedicine.com/medline/citation/23462281/full_citation L2 - http://dx.doi.org/10.1111/cns.12078 ER -