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Safety and efficacy studies on trivalent inactivated vaccines against infectious coryza.
Vet Immunol Immunopathol 2014; 158(1-2):3-7VI

Abstract

The safety and efficacy of an inactivated oil-emulsion infectious coryza vaccine containing three Avibacterium paragallinarum isolates (one each of Page serovars A, B, and C) was evaluated. The safety of six batches of the vaccine was confirmed by testing with chickens vaccinated with a single large dose or vaccinated repeatedly with a normal dose. Efficacy tests were carried out on three batches of vaccine using both specific pathogen free (SPF) chickens and conventional chickens. In SPF chickens given a single vaccination at 42 days of age, the protection rate against all three serovars of Av. paragallinarum was at least 80% at 30 days post vaccination. The conventional chickens, which were immunized at 42 and 110 days of age, were challenged at 9 months post the second vaccination and the protection rate was at least 80% for all three serovars. The effect of storage on the vaccine was evaluated in SPF chickens using three batches of vaccine stored at 4-8°C for 1 year. The protection rate against challenge from all three serovars (single vaccination at 42 days of age and challenge at 30 days post-vaccination) was at least 80%.

Authors+Show Affiliations

Institute of Animal Husbandry and Veterinary Science, Beijing Academy of Agricultural and Forestry Science, Beijing 100097, People's Republic of China.Institute of Animal Husbandry and Veterinary Science, Beijing Academy of Agricultural and Forestry Science, Beijing 100097, People's Republic of China.Institute of Animal Husbandry and Veterinary Science, Beijing Academy of Agricultural and Forestry Science, Beijing 100097, People's Republic of China.Beijing Sinder Vet-Technology Co. Ltd., Shunyi, Beijing 101302, People's Republic of China.Institute of Animal Husbandry and Veterinary Science, Beijing Academy of Agricultural and Forestry Science, Beijing 100097, People's Republic of China.Institute of Animal Husbandry and Veterinary Science, Beijing Academy of Agricultural and Forestry Science, Beijing 100097, People's Republic of China.Beijing Sinder Vet-Technology Co. Ltd., Shunyi, Beijing 101302, People's Republic of China.Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, EcoSciences Precinct, Dutton Park 4001, Brisbane, Australia. Electronic address: p.blackall@uq.edu.au.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23462450

Citation

Gong, Yumei, et al. "Safety and Efficacy Studies On Trivalent Inactivated Vaccines Against Infectious Coryza." Veterinary Immunology and Immunopathology, vol. 158, no. 1-2, 2014, pp. 3-7.
Gong Y, Zhang P, Wang H, et al. Safety and efficacy studies on trivalent inactivated vaccines against infectious coryza. Vet Immunol Immunopathol. 2014;158(1-2):3-7.
Gong, Y., Zhang, P., Wang, H., Zhu, W., Sun, H., He, Y., ... Blackall, P. J. (2014). Safety and efficacy studies on trivalent inactivated vaccines against infectious coryza. Veterinary Immunology and Immunopathology, 158(1-2), pp. 3-7. doi:10.1016/j.vetimm.2013.01.015.
Gong Y, et al. Safety and Efficacy Studies On Trivalent Inactivated Vaccines Against Infectious Coryza. Vet Immunol Immunopathol. 2014 Mar 15;158(1-2):3-7. PubMed PMID: 23462450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety and efficacy studies on trivalent inactivated vaccines against infectious coryza. AU - Gong,Yumei, AU - Zhang,Peijun, AU - Wang,Hongjun, AU - Zhu,Wenge, AU - Sun,Huiling, AU - He,Yunxia, AU - Shao,Qinghong, AU - Blackall,P J, Y1 - 2013/02/08/ PY - 2012/09/22/received PY - 2013/01/11/revised PY - 2013/01/11/accepted PY - 2013/3/7/entrez PY - 2013/3/7/pubmed PY - 2014/11/8/medline KW - Infectious Coryza KW - Potency test KW - Safety test KW - Trivalent inactivated vaccine SP - 3 EP - 7 JF - Veterinary immunology and immunopathology JO - Vet. Immunol. Immunopathol. VL - 158 IS - 1-2 N2 - The safety and efficacy of an inactivated oil-emulsion infectious coryza vaccine containing three Avibacterium paragallinarum isolates (one each of Page serovars A, B, and C) was evaluated. The safety of six batches of the vaccine was confirmed by testing with chickens vaccinated with a single large dose or vaccinated repeatedly with a normal dose. Efficacy tests were carried out on three batches of vaccine using both specific pathogen free (SPF) chickens and conventional chickens. In SPF chickens given a single vaccination at 42 days of age, the protection rate against all three serovars of Av. paragallinarum was at least 80% at 30 days post vaccination. The conventional chickens, which were immunized at 42 and 110 days of age, were challenged at 9 months post the second vaccination and the protection rate was at least 80% for all three serovars. The effect of storage on the vaccine was evaluated in SPF chickens using three batches of vaccine stored at 4-8°C for 1 year. The protection rate against challenge from all three serovars (single vaccination at 42 days of age and challenge at 30 days post-vaccination) was at least 80%. SN - 1873-2534 UR - https://www.unboundmedicine.com/medline/citation/23462450/Safety_and_efficacy_studies_on_trivalent_inactivated_vaccines_against_infectious_coryza_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-2427(13)00051-2 DB - PRIME DP - Unbound Medicine ER -