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Effect of illness expression and liability on familial associations of clinical and subclinical psychosis phenotypes.
Acta Psychiatr Scand 2014; 129(1):44-53AP

Abstract

OBJECTIVE

Given the familial influences on schizophrenia, it may be hypothesized that specific symptom domains also cluster within families, and that this applies to both clinical and subclinical levels of expression. This hypothesis was put to the test in a group of patients with a DSM-IV diagnosis of psychotic disorder together with their unaffected siblings, and a group of healthy sib-pairs.

METHOD

Subclinical positive, negative and depressive symptoms in relatives and healthy controls were assessed with the Community Assessment of Psychic Experiences (CAPE). Positive and negative schizotypy in relatives and controls was measured with the Structured Interview for Schizotypy-Revised. Multilevel linear regression analyses were conducted to investigate clustering of symptom dimensions within patient-relative sib-pairs (N = 811 pairs), healthy sib-pairs of affected families (N = 136 pairs) and healthy control sib-pairs (N = 58 pairs).

RESULTS

Familial clustering of symptoms was found in all three groups. Effect sizes were largest in healthy control sib-pairs, smallest in patient-relative sib-pairs and intermediate in healthy sib-pairs of affected families.

CONCLUSION

Studies of sibling associations in genetic studies of psychometric expression of psychosis liability need to take into account the fact that the higher levels of background genetic risk and presence of diagnosed illness are inversely associated with sibling associations.

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    Authors+Show Affiliations

    Lataster T
    South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, Maastricht, the Netherlands.
    Verweij K
    No affiliation info available
    Viechtbauer W
    No affiliation info available
    GROUP
    No affiliation info available

    MeSH

    AdolescentAdultCase-Control StudiesDepressionFemaleHumansLinear ModelsMaleMiddle AgedMultilevel AnalysisPhenotypePsychotic DisordersSchizophreniaSchizophrenic PsychologySeverity of Illness IndexSiblingsYoung Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23465170

    Citation

    Lataster, T, et al. "Effect of Illness Expression and Liability On Familial Associations of Clinical and Subclinical Psychosis Phenotypes." Acta Psychiatrica Scandinavica, vol. 129, no. 1, 2014, pp. 44-53.
    Lataster T, Verweij K, Viechtbauer W, et al. Effect of illness expression and liability on familial associations of clinical and subclinical psychosis phenotypes. Acta Psychiatr Scand. 2014;129(1):44-53.
    Lataster, T., Verweij, K., & Viechtbauer, W. (2014). Effect of illness expression and liability on familial associations of clinical and subclinical psychosis phenotypes. Acta Psychiatrica Scandinavica, 129(1), pp. 44-53. doi:10.1111/acps.12102.
    Lataster T, et al. Effect of Illness Expression and Liability On Familial Associations of Clinical and Subclinical Psychosis Phenotypes. Acta Psychiatr Scand. 2014;129(1):44-53. PubMed PMID: 23465170.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of illness expression and liability on familial associations of clinical and subclinical psychosis phenotypes. AU - Lataster,T, AU - Verweij,K, AU - Viechtbauer,W, AU - ,, Y1 - 2013/03/07/ PY - 2013/01/22/accepted PY - 2013/3/8/entrez PY - 2013/3/8/pubmed PY - 2014/9/2/medline KW - family studies KW - genetic epidemiology KW - psychopathology KW - schizophrenia SP - 44 EP - 53 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 129 IS - 1 N2 - OBJECTIVE: Given the familial influences on schizophrenia, it may be hypothesized that specific symptom domains also cluster within families, and that this applies to both clinical and subclinical levels of expression. This hypothesis was put to the test in a group of patients with a DSM-IV diagnosis of psychotic disorder together with their unaffected siblings, and a group of healthy sib-pairs. METHOD: Subclinical positive, negative and depressive symptoms in relatives and healthy controls were assessed with the Community Assessment of Psychic Experiences (CAPE). Positive and negative schizotypy in relatives and controls was measured with the Structured Interview for Schizotypy-Revised. Multilevel linear regression analyses were conducted to investigate clustering of symptom dimensions within patient-relative sib-pairs (N = 811 pairs), healthy sib-pairs of affected families (N = 136 pairs) and healthy control sib-pairs (N = 58 pairs). RESULTS: Familial clustering of symptoms was found in all three groups. Effect sizes were largest in healthy control sib-pairs, smallest in patient-relative sib-pairs and intermediate in healthy sib-pairs of affected families. CONCLUSION: Studies of sibling associations in genetic studies of psychometric expression of psychosis liability need to take into account the fact that the higher levels of background genetic risk and presence of diagnosed illness are inversely associated with sibling associations. SN - 1600-0447 UR - https://www.unboundmedicine.com/medline/citation/23465170/Effect_of_illness_expression_and_liability_on_familial_associations_of_clinical_and_subclinical_psychosis_phenotypes_ L2 - https://doi.org/10.1111/acps.12102 DB - PRIME DP - Unbound Medicine ER -