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Comparison of cone pathologic changes in idiopathic macular telangiectasia types 1 and 2 using adaptive optics scanning laser ophthalmoscopy.
Am J Ophthalmol. 2013 Jun; 155(6):1045-1057.e4.AJ

Abstract

PURPOSE

To compare pathologic changes in the photoreceptors of eyes with idiopathic macular telangiectasia types 1 and 2 using adaptive optics scanning laser ophthalmoscopy (AO-SLO).

DESIGN

Prospective cross-sectional study.

METHODS

Eleven eyes with idiopathic macular telangiectasia type 1, 14 eyes with type 2, and 10 normal eyes underwent a full ophthalmologic examination, spectral-domain optical coherence tomography (SD-OCT), and imaging with an original prototype AO-SLO system. All eyes with idiopathic macular telangiectasia were examined with fluorescein angiography (FA), confocal blue reflectance, and microperimetry.

RESULTS

Compared with normal eyes (29 017 ± 5507 cones/mm(2)), those with idiopathic macular telangiectasia type 1 had significantly lower cone density on the temporal side (18 427 ± 4908 cones/mm(2), P = .010). The FA leakage area (5.90 ± 3.23 mm(2)) was larger than the dark regions (2.45 ± 2.40 mm(2)) on AO-SLO (P = .003)-which were observed only in the FA leakage area. Compared with normal eyes, those with idiopathic macular telangiectasia type 2 had significantly lower cone density in all areas (P < .05 for all). Patchy dark regions were also seen in areas without FA abnormalities in 12 eyes. Higher mean retinal sensitivity correlated with greater mean cone density 0.5 mm from the center of the fovea (type 1: P = .010; type 2: P < .001).

CONCLUSIONS

Idiopathic macular telangiectasia type-specific differences in the distribution of photoreceptor abnormalities were shown in the AO-SLO images. For both idiopathic macular telangiectasia types 1 and 2, visual impairment was associated with cone damage.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. ohoto@kuhp.kyoto-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23465268

Citation

Ooto, Sotaro, et al. "Comparison of Cone Pathologic Changes in Idiopathic Macular Telangiectasia Types 1 and 2 Using Adaptive Optics Scanning Laser Ophthalmoscopy." American Journal of Ophthalmology, vol. 155, no. 6, 2013, pp. 1045-1057.e4.
Ooto S, Hangai M, Takayama K, et al. Comparison of cone pathologic changes in idiopathic macular telangiectasia types 1 and 2 using adaptive optics scanning laser ophthalmoscopy. Am J Ophthalmol. 2013;155(6):1045-1057.e4.
Ooto, S., Hangai, M., Takayama, K., Ueda-Arakawa, N., Tsujikawa, A., Yamashiro, K., Oishi, A., Hanebuchi, M., & Yoshimura, N. (2013). Comparison of cone pathologic changes in idiopathic macular telangiectasia types 1 and 2 using adaptive optics scanning laser ophthalmoscopy. American Journal of Ophthalmology, 155(6), 1045-e4. https://doi.org/10.1016/j.ajo.2013.01.006
Ooto S, et al. Comparison of Cone Pathologic Changes in Idiopathic Macular Telangiectasia Types 1 and 2 Using Adaptive Optics Scanning Laser Ophthalmoscopy. Am J Ophthalmol. 2013;155(6):1045-1057.e4. PubMed PMID: 23465268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of cone pathologic changes in idiopathic macular telangiectasia types 1 and 2 using adaptive optics scanning laser ophthalmoscopy. AU - Ooto,Sotaro, AU - Hangai,Masanori, AU - Takayama,Kohei, AU - Ueda-Arakawa,Naoko, AU - Tsujikawa,Akitaka, AU - Yamashiro,Kenji, AU - Oishi,Akio, AU - Hanebuchi,Masaaki, AU - Yoshimura,Nagahisa, Y1 - 2013/03/07/ PY - 2012/09/25/received PY - 2013/01/03/revised PY - 2013/01/03/accepted PY - 2013/3/8/entrez PY - 2013/3/8/pubmed PY - 2013/7/19/medline SP - 1045 EP - 1057.e4 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 155 IS - 6 N2 - PURPOSE: To compare pathologic changes in the photoreceptors of eyes with idiopathic macular telangiectasia types 1 and 2 using adaptive optics scanning laser ophthalmoscopy (AO-SLO). DESIGN: Prospective cross-sectional study. METHODS: Eleven eyes with idiopathic macular telangiectasia type 1, 14 eyes with type 2, and 10 normal eyes underwent a full ophthalmologic examination, spectral-domain optical coherence tomography (SD-OCT), and imaging with an original prototype AO-SLO system. All eyes with idiopathic macular telangiectasia were examined with fluorescein angiography (FA), confocal blue reflectance, and microperimetry. RESULTS: Compared with normal eyes (29 017 ± 5507 cones/mm(2)), those with idiopathic macular telangiectasia type 1 had significantly lower cone density on the temporal side (18 427 ± 4908 cones/mm(2), P = .010). The FA leakage area (5.90 ± 3.23 mm(2)) was larger than the dark regions (2.45 ± 2.40 mm(2)) on AO-SLO (P = .003)-which were observed only in the FA leakage area. Compared with normal eyes, those with idiopathic macular telangiectasia type 2 had significantly lower cone density in all areas (P < .05 for all). Patchy dark regions were also seen in areas without FA abnormalities in 12 eyes. Higher mean retinal sensitivity correlated with greater mean cone density 0.5 mm from the center of the fovea (type 1: P = .010; type 2: P < .001). CONCLUSIONS: Idiopathic macular telangiectasia type-specific differences in the distribution of photoreceptor abnormalities were shown in the AO-SLO images. For both idiopathic macular telangiectasia types 1 and 2, visual impairment was associated with cone damage. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/23465268/Comparison_of_cone_pathologic_changes_in_idiopathic_macular_telangiectasia_types_1_and_2_using_adaptive_optics_scanning_laser_ophthalmoscopy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(13)00023-8 DB - PRIME DP - Unbound Medicine ER -