Tags

Type your tag names separated by a space and hit enter

Effects of olive polyphenols administration on nerve growth factor and brain-derived neurotrophic factor in the mouse brain.
Nutrition. 2013 Apr; 29(4):681-7.N

Abstract

OBJECTIVE

Polyphenols are chemicals derived from plants known to possess antioxidant and anti-inflammatory properties. High intake of fruit and vegetables is believed to be beneficial to human health. Various studies have suggested that dietary polyphenols may protect against cancer and cardiometabolic and neurodegenerative diseases. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are neurotrophins that play key roles in brain cell development, growth, and survival. The aim of this study was to investigate whether or not administration of olive (Olea europaea L.) polyphenols could have an effect on NGF and BDNF content and the expression of their receptors, TrkA and TrkB, respectively, in the mouse brain.

METHODS

NGF and BDNF were measured by enzyme-linked immunosorbent assay. TrkA and TrkB were measured by Western blotting.

RESULTS

We found NGF and BDNF elevation in the hippocampus and olfactory bulbs and a decrease in the frontal cortex and striatum. These data were associated with potentiated expression of TrkA and TrkB in the hippocampus and olfactory bulbs but no differences between groups in the striatum and frontal cortex. Polyphenols did not affect some behavioral mouse parameters associated with stressing situations.

CONCLUSIONS

Altogether, this study shows that olive polyphenols in the mouse may increase the levels of NGF and BDNF in crucial areas of the limbic system and olfactory bulbs, which play a key role in learning and memory processes and in the proliferation and migration of endogenous progenitor cells present in the rodent brain.

Links

Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

De Nicoló S
Istituto di Biologia Cellulare e Neurobiologia, CNR, Rome, Italy.
Tarani L
No affiliation info available
Ceccanti M
No affiliation info available
Maldini M
No affiliation info available
Natella F
No affiliation info available
Vania A
No affiliation info available
Chaldakov GN
No affiliation info available
Fiore M
No affiliation info available

MeSH

AnimalsAnimals, Outbred StrainsAntioxidantsBrain-Derived Neurotrophic FactorCorpus StriatumDietary SupplementsDown-RegulationFood-Processing IndustryFrontal LobeFruitHippocampusIndustrial WasteMaleMiceNerve Growth FactorNeuronsOleaOlfactory BulbPlant ExtractsPolyphenolsReceptor, trkAReceptor, trkBUp-Regulation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23466052

Citation

De Nicoló, Sara, et al. "Effects of Olive Polyphenols Administration On Nerve Growth Factor and Brain-derived Neurotrophic Factor in the Mouse Brain." Nutrition (Burbank, Los Angeles County, Calif.), vol. 29, no. 4, 2013, pp. 681-7.
De Nicoló S, Tarani L, Ceccanti M, et al. Effects of olive polyphenols administration on nerve growth factor and brain-derived neurotrophic factor in the mouse brain. Nutrition. 2013;29(4):681-7.
De Nicoló, S., Tarani, L., Ceccanti, M., Maldini, M., Natella, F., Vania, A., Chaldakov, G. N., & Fiore, M. (2013). Effects of olive polyphenols administration on nerve growth factor and brain-derived neurotrophic factor in the mouse brain. Nutrition (Burbank, Los Angeles County, Calif.), 29(4), 681-7. https://doi.org/10.1016/j.nut.2012.11.007
De Nicoló S, et al. Effects of Olive Polyphenols Administration On Nerve Growth Factor and Brain-derived Neurotrophic Factor in the Mouse Brain. Nutrition. 2013;29(4):681-7. PubMed PMID: 23466052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of olive polyphenols administration on nerve growth factor and brain-derived neurotrophic factor in the mouse brain. AU - De Nicoló,Sara, AU - Tarani,Luigi, AU - Ceccanti,Mauro, AU - Maldini,Mariateresa, AU - Natella,Fausta, AU - Vania,Andrea, AU - Chaldakov,George N, AU - Fiore,Marco, PY - 2012/07/30/received PY - 2012/11/14/revised PY - 2012/11/21/accepted PY - 2013/3/8/entrez PY - 2013/3/8/pubmed PY - 2013/9/5/medline SP - 681 EP - 7 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 29 IS - 4 N2 - OBJECTIVE: Polyphenols are chemicals derived from plants known to possess antioxidant and anti-inflammatory properties. High intake of fruit and vegetables is believed to be beneficial to human health. Various studies have suggested that dietary polyphenols may protect against cancer and cardiometabolic and neurodegenerative diseases. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are neurotrophins that play key roles in brain cell development, growth, and survival. The aim of this study was to investigate whether or not administration of olive (Olea europaea L.) polyphenols could have an effect on NGF and BDNF content and the expression of their receptors, TrkA and TrkB, respectively, in the mouse brain. METHODS: NGF and BDNF were measured by enzyme-linked immunosorbent assay. TrkA and TrkB were measured by Western blotting. RESULTS: We found NGF and BDNF elevation in the hippocampus and olfactory bulbs and a decrease in the frontal cortex and striatum. These data were associated with potentiated expression of TrkA and TrkB in the hippocampus and olfactory bulbs but no differences between groups in the striatum and frontal cortex. Polyphenols did not affect some behavioral mouse parameters associated with stressing situations. CONCLUSIONS: Altogether, this study shows that olive polyphenols in the mouse may increase the levels of NGF and BDNF in crucial areas of the limbic system and olfactory bulbs, which play a key role in learning and memory processes and in the proliferation and migration of endogenous progenitor cells present in the rodent brain. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/23466052/Effects_of_olive_polyphenols_administration_on_nerve_growth_factor_and_brain_derived_neurotrophic_factor_in_the_mouse_brain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(12)00430-3 DB - PRIME DP - Unbound Medicine ER -