Tags

Type your tag names separated by a space and hit enter

Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety.
Am J Clin Nutr. 2013 May; 97(5):980-9.AJ

Abstract

BACKGROUND

Effects of protein intake on appetite-regulating hormones and their dynamics are unclear.

OBJECTIVES

We investigated the satiating effects of meals with varying protein contents and whether there was an effect of dose on appetite-regulating hormones and appetite ratings.

DESIGN

Twenty-five men [mean ± SD age: 30.0 ± 8.7 y; body mass index (BMI; in kg/m(2)): 25.9 ± 4.7] participated in the 3-way, randomized, double-blind crossover study. Test meals were isocaloric with 30% of energy from fat and protein content adjusted at the expense of carbohydrate. Test meals were normal protein (NP; 14% of energy from protein), medium-high protein (MHP; 25% of energy from protein), and high protein (HP, 50% of energy from protein). Appetite ratings and blood samples were assessed every 0.5 h for 4 h. An ad libitum lunch was served 4 h after the meal.

RESULTS

Protein increased dose-dependently glucagon-like peptide-1 (GLP-1), peptide YY (PYY) 3-36, and glucagon; MHP produced 10%, 7%, and 47% greater responses, respectively; and HP produced 20%, 14%, and 116% greater responses, respectively, than did NP (P < 0.03). Compared with NP, HP increased insulin and cholecystokinin and decreased ghrelin and glucose-dependent insulinotropic polypeptide (P < 0.05). Satiety and fullness dose-dependently increased by 7% and 6% for MHP and 16% and 19% for HP compared with NP (P < 0.001). Hunger and prospective consumption dose-dependently decreased by 15% and 13% for MHP and by 25% and 26% for HP compared with NP (P < 0.0003). There was a combined effect of GLP-1 and PYY 3-36 (P = 0.03) next to the additive effect of GLP-1 (P = 0.006) on the composite appetite score. No difference was shown in ad libitum energy intake.

CONCLUSION

Protein dose-dependently increased satiety and GLP-1, PYY 3-36, and glucagon, which may, at least in part, be responsible for the satiety-stimulating effect of protein. This trial was registered at clinicaltrials.gov as NCT01561235.

Authors+Show Affiliations

Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23466396

Citation

Belza, Anita, et al. "Contribution of Gastroenteropancreatic Appetite Hormones to Protein-induced Satiety." The American Journal of Clinical Nutrition, vol. 97, no. 5, 2013, pp. 980-9.
Belza A, Ritz C, Sørensen MQ, et al. Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety. Am J Clin Nutr. 2013;97(5):980-9.
Belza, A., Ritz, C., Sørensen, M. Q., Holst, J. J., Rehfeld, J. F., & Astrup, A. (2013). Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety. The American Journal of Clinical Nutrition, 97(5), 980-9. https://doi.org/10.3945/ajcn.112.047563
Belza A, et al. Contribution of Gastroenteropancreatic Appetite Hormones to Protein-induced Satiety. Am J Clin Nutr. 2013;97(5):980-9. PubMed PMID: 23466396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety. AU - Belza,Anita, AU - Ritz,Christian, AU - Sørensen,Mejse Q, AU - Holst,Jens J, AU - Rehfeld,Jens F, AU - Astrup,Arne, Y1 - 2013/03/06/ PY - 2013/3/8/entrez PY - 2013/3/8/pubmed PY - 2013/6/19/medline SP - 980 EP - 9 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 97 IS - 5 N2 - BACKGROUND: Effects of protein intake on appetite-regulating hormones and their dynamics are unclear. OBJECTIVES: We investigated the satiating effects of meals with varying protein contents and whether there was an effect of dose on appetite-regulating hormones and appetite ratings. DESIGN: Twenty-five men [mean ± SD age: 30.0 ± 8.7 y; body mass index (BMI; in kg/m(2)): 25.9 ± 4.7] participated in the 3-way, randomized, double-blind crossover study. Test meals were isocaloric with 30% of energy from fat and protein content adjusted at the expense of carbohydrate. Test meals were normal protein (NP; 14% of energy from protein), medium-high protein (MHP; 25% of energy from protein), and high protein (HP, 50% of energy from protein). Appetite ratings and blood samples were assessed every 0.5 h for 4 h. An ad libitum lunch was served 4 h after the meal. RESULTS: Protein increased dose-dependently glucagon-like peptide-1 (GLP-1), peptide YY (PYY) 3-36, and glucagon; MHP produced 10%, 7%, and 47% greater responses, respectively; and HP produced 20%, 14%, and 116% greater responses, respectively, than did NP (P < 0.03). Compared with NP, HP increased insulin and cholecystokinin and decreased ghrelin and glucose-dependent insulinotropic polypeptide (P < 0.05). Satiety and fullness dose-dependently increased by 7% and 6% for MHP and 16% and 19% for HP compared with NP (P < 0.001). Hunger and prospective consumption dose-dependently decreased by 15% and 13% for MHP and by 25% and 26% for HP compared with NP (P < 0.0003). There was a combined effect of GLP-1 and PYY 3-36 (P = 0.03) next to the additive effect of GLP-1 (P = 0.006) on the composite appetite score. No difference was shown in ad libitum energy intake. CONCLUSION: Protein dose-dependently increased satiety and GLP-1, PYY 3-36, and glucagon, which may, at least in part, be responsible for the satiety-stimulating effect of protein. This trial was registered at clinicaltrials.gov as NCT01561235. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/23466396/Contribution_of_gastroenteropancreatic_appetite_hormones_to_protein_induced_satiety_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.047563 DB - PRIME DP - Unbound Medicine ER -