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Associations of candidate biomarkers of vascular disease with the ankle-brachial index and peripheral arterial disease.
Am J Hypertens. 2013 Apr; 26(4):495-502.AJ

Abstract

BACKGROUND

The use of multiple biomarkers representing various etiologic pathways of atherosclerosis may improve the prediction of interindividual variation in the ankle-brachial index (ABI). To this end, we investigated associations of 47 candidate biomarkers with the ABI and presence of peripheral arterial disease (PAD) in African-Americans (AAs) and non-Hispanic whites (NHWs).

METHODS

Study participants included 1,291 AAs (71.1% women, mean age, 63.4±9.3 years) and 1,152 NHWs (57.5% women, mean age 58.5±10.1 years) belonging to hypertensive sibships. Peripheral arterial disease was defined as an ABI ≤ 0.90. Circulating levels of 47 candidate biomarkers were log-transformed before analysis because of skewed distribution. Multivariate regression analyses were used to identify biomarkers associated with ABI or PAD independently of age, sex, conventional risk factors, and medication use.

RESULTS

After adjustment for covariates, higher levels of nine biomarkers were associated with a lower ABI in AAs (all P ≤ 0.005); these biomarkers were C-reactive protein (CRP), interleukin-6, tumor necrosis factor receptor-II (TNF-R II), lipoprotein(a), N-terminal pro-brain natriuretic peptide (NT-proBNP), pro-atrial natriuretic peptide, C-terminal pro-arginine vasopressin, osteoprotegerin, and fibrinogen. Three biomarkers - myeloperoxidase, NT-proBNP, and D-dimer - were associated with ABI in NHWs (all P ≤ 0.01). C-reactive protein, interleukin-6, TNF-R II, lipoprotein(a), NT-proBNP, pro-atrial natriuretic peptide, D-dimer, and fibrinogen were associated with PAD (all P ≤ 0.005) in AAs after adjustment for covariates. None of the biomarkers were independently associated with PAD in NHWs.

CONCLUSION

A multimarker approach improved the prediction of interindividual variation in the ABI in AAs and NHWs, and improved prediction of the presence of PAD in AAs.

Authors+Show Affiliations

Division of Cardiovascular Diseases and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23467205

Citation

Ye, Zi, et al. "Associations of Candidate Biomarkers of Vascular Disease With the Ankle-brachial Index and Peripheral Arterial Disease." American Journal of Hypertension, vol. 26, no. 4, 2013, pp. 495-502.
Ye Z, Ali Z, Klee GG, et al. Associations of candidate biomarkers of vascular disease with the ankle-brachial index and peripheral arterial disease. Am J Hypertens. 2013;26(4):495-502.
Ye, Z., Ali, Z., Klee, G. G., Mosley, T. H., & Kullo, I. J. (2013). Associations of candidate biomarkers of vascular disease with the ankle-brachial index and peripheral arterial disease. American Journal of Hypertension, 26(4), 495-502. https://doi.org/10.1093/ajh/hps073
Ye Z, et al. Associations of Candidate Biomarkers of Vascular Disease With the Ankle-brachial Index and Peripheral Arterial Disease. Am J Hypertens. 2013;26(4):495-502. PubMed PMID: 23467205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of candidate biomarkers of vascular disease with the ankle-brachial index and peripheral arterial disease. AU - Ye,Zi, AU - Ali,Zeenat, AU - Klee,George G, AU - Mosley,Thomas H,Jr AU - Kullo,Iftikhar J, Y1 - 2013/01/11/ PY - 2013/3/8/entrez PY - 2013/3/8/pubmed PY - 2013/8/27/medline SP - 495 EP - 502 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 26 IS - 4 N2 - BACKGROUND: The use of multiple biomarkers representing various etiologic pathways of atherosclerosis may improve the prediction of interindividual variation in the ankle-brachial index (ABI). To this end, we investigated associations of 47 candidate biomarkers with the ABI and presence of peripheral arterial disease (PAD) in African-Americans (AAs) and non-Hispanic whites (NHWs). METHODS: Study participants included 1,291 AAs (71.1% women, mean age, 63.4±9.3 years) and 1,152 NHWs (57.5% women, mean age 58.5±10.1 years) belonging to hypertensive sibships. Peripheral arterial disease was defined as an ABI ≤ 0.90. Circulating levels of 47 candidate biomarkers were log-transformed before analysis because of skewed distribution. Multivariate regression analyses were used to identify biomarkers associated with ABI or PAD independently of age, sex, conventional risk factors, and medication use. RESULTS: After adjustment for covariates, higher levels of nine biomarkers were associated with a lower ABI in AAs (all P ≤ 0.005); these biomarkers were C-reactive protein (CRP), interleukin-6, tumor necrosis factor receptor-II (TNF-R II), lipoprotein(a), N-terminal pro-brain natriuretic peptide (NT-proBNP), pro-atrial natriuretic peptide, C-terminal pro-arginine vasopressin, osteoprotegerin, and fibrinogen. Three biomarkers - myeloperoxidase, NT-proBNP, and D-dimer - were associated with ABI in NHWs (all P ≤ 0.01). C-reactive protein, interleukin-6, TNF-R II, lipoprotein(a), NT-proBNP, pro-atrial natriuretic peptide, D-dimer, and fibrinogen were associated with PAD (all P ≤ 0.005) in AAs after adjustment for covariates. None of the biomarkers were independently associated with PAD in NHWs. CONCLUSION: A multimarker approach improved the prediction of interindividual variation in the ABI in AAs and NHWs, and improved prediction of the presence of PAD in AAs. SN - 1941-7225 UR - https://www.unboundmedicine.com/medline/citation/23467205/Associations_of_candidate_biomarkers_of_vascular_disease_with_the_ankle_brachial_index_and_peripheral_arterial_disease_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1093/ajh/hps073 DB - PRIME DP - Unbound Medicine ER -