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Effect of fat mass and lean mass on bone mineral density in postmenopausal and perimenopausal Thai women.
Int J Womens Health. 2013; 5:87-92.IJ

Abstract

BACKGROUND

The purpose of this study was to investigate the association between fat mass, lean mass, and bone mineral density (BMD) in postmenopausal and perimenopausal Thai women.

METHODS

A cross-sectional study was conducted in 1579 healthy Thai women aged 40-90 years. Total body, lumbar spine, total femur, and femoral neck BMD and body composition were measured by dual x-ray absorptiometry. To evaluate the associations between fat mass and lean mass and various measures of BMD, multivariable linear regression models were used to estimate the regression coefficients for fat mass and lean mass, first in separate equations and then with both fat mass and lean mass in the same equation.

RESULTS

Among the study population, 1448 subjects (91.7%) were postmenopausal and 131 (8.3%) were perimenopausal. In postmenopausal women, after controlling for age, height, and duration of menopause, both fat mass and lean mass were positively correlated with BMD when they were analyzed independently of each other. When included in the same equation, both fat mass and lean mass continued to show a positive effect, but lean mass had a significantly greater impact on BMD than fat mass at all regions except for total body. Lean mass but not fat mass had a positive effect on BMD at all skeletal sites except the lumbar spine, after controlling for age and height in perimenopausal women.

CONCLUSION

Lean mass had a significant beneficial effect on BMD in both postmenopausal and perimenopausal women and can be considered as one of the determinants of bone mass. The effect of the fat mass was related to menopausal status, but only demonstrated a positive impact in perimenopausal women.

Authors+Show Affiliations

Clinical Epidemiology Program and Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23467695

Citation

Namwongprom, Sirianong, et al. "Effect of Fat Mass and Lean Mass On Bone Mineral Density in Postmenopausal and Perimenopausal Thai Women." International Journal of Women's Health, vol. 5, 2013, pp. 87-92.
Namwongprom S, Rojanasthien S, Mangklabruks A, et al. Effect of fat mass and lean mass on bone mineral density in postmenopausal and perimenopausal Thai women. Int J Womens Health. 2013;5:87-92.
Namwongprom, S., Rojanasthien, S., Mangklabruks, A., Soontrapa, S., Wongboontan, C., & Ongphiphadhanakul, B. (2013). Effect of fat mass and lean mass on bone mineral density in postmenopausal and perimenopausal Thai women. International Journal of Women's Health, 5, 87-92. https://doi.org/10.2147/IJWH.S41884
Namwongprom S, et al. Effect of Fat Mass and Lean Mass On Bone Mineral Density in Postmenopausal and Perimenopausal Thai Women. Int J Womens Health. 2013;5:87-92. PubMed PMID: 23467695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of fat mass and lean mass on bone mineral density in postmenopausal and perimenopausal Thai women. AU - Namwongprom,Sirianong, AU - Rojanasthien,Sattaya, AU - Mangklabruks,Ampica, AU - Soontrapa,Supasil, AU - Wongboontan,Chanpen, AU - Ongphiphadhanakul,Boonsong, Y1 - 2013/02/27/ PY - 2013/3/8/entrez PY - 2013/3/8/pubmed PY - 2013/3/8/medline KW - bone mineral density KW - fat mass KW - lean mass SP - 87 EP - 92 JF - International journal of women's health JO - Int J Womens Health VL - 5 N2 - BACKGROUND: The purpose of this study was to investigate the association between fat mass, lean mass, and bone mineral density (BMD) in postmenopausal and perimenopausal Thai women. METHODS: A cross-sectional study was conducted in 1579 healthy Thai women aged 40-90 years. Total body, lumbar spine, total femur, and femoral neck BMD and body composition were measured by dual x-ray absorptiometry. To evaluate the associations between fat mass and lean mass and various measures of BMD, multivariable linear regression models were used to estimate the regression coefficients for fat mass and lean mass, first in separate equations and then with both fat mass and lean mass in the same equation. RESULTS: Among the study population, 1448 subjects (91.7%) were postmenopausal and 131 (8.3%) were perimenopausal. In postmenopausal women, after controlling for age, height, and duration of menopause, both fat mass and lean mass were positively correlated with BMD when they were analyzed independently of each other. When included in the same equation, both fat mass and lean mass continued to show a positive effect, but lean mass had a significantly greater impact on BMD than fat mass at all regions except for total body. Lean mass but not fat mass had a positive effect on BMD at all skeletal sites except the lumbar spine, after controlling for age and height in perimenopausal women. CONCLUSION: Lean mass had a significant beneficial effect on BMD in both postmenopausal and perimenopausal women and can be considered as one of the determinants of bone mass. The effect of the fat mass was related to menopausal status, but only demonstrated a positive impact in perimenopausal women. SN - 1179-1411 UR - https://www.unboundmedicine.com/medline/citation/23467695/Effect_of_fat_mass_and_lean_mass_on_bone_mineral_density_in_postmenopausal_and_perimenopausal_Thai_women_ L2 - https://dx.doi.org/10.2147/IJWH.S41884 DB - PRIME DP - Unbound Medicine ER -
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