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The prevalence and antibiotics susceptibility pattern of Neisseria gonorrhoeae in patients attending OPD clinics at St. Mary's Hospital Lacor Uganda.
J Prev Med Hyg. 2012 Dec; 53(4):186-9.JP

Abstract

INTRODUCTION

Gonorrhea is one of the most common sexually transmitted infections (STls) in developing countries, and the emergence of resistance to antimicrobial agents in Neisseria gonorrhoeae is a major obstacle in the control of gonorrhoea. Periodical determination of the prevalence and monitoring of antimicrobial susceptibility of N. gonorrhoeae is essential for the early detection of emergence of drug resistance.

METHODS

A total of 640 consecutive patients who attended the Outpatient Department (OPD) Clinics at St. Mary's Hospital Lacor between Jan 2007-Dec 2011, with gonococcal urethriris symptoms and whose urethral swabs and high vagina swabs (HVS) were cultured, were involved in the study. Two hundred and fifty six (256) patients had positive pus swab culture, of which 151 (23.6%) showed growth of Neisseria gonorrhoeae. All the isolates were tested for antimicrobial susceptibility using the Kirby Bauer-disc diffusion techniques.

RESULTS

Gonococcal isolates showed rapid decrease in susceptibility to the antimicrobials especially to ampicillin, tetracycline and erythomycin, ciprofloxacin, and intermediate to chloramphenicol, however, gentamicin and cefotaxime have remained as a single dose sensitive treatment for Neisseria gonorrhoeae. Sensitization on drug use and adopting preventive measures and continuous education on safer sexual behavior through health care authorities would lead to reduction in the prevalence of Neisseria gonorrhoeae and resistance to antimicrobial.

DISCUSSION

Gonorrhea is one of the most common sexually transmitted infections (STIs) in developing countries, and the emergence of resistance to antimicrobial agents in Neisseria gonorrhoeae is a major obstacle in the control of gonorrhea. Periodical monitoring of antimicrobial susceptibility of N. gonorrhea is essential for the early detection of emergence of drug resistance.

Authors+Show Affiliations

Department of Microbiology, St. Mary's Hospital Lacor, Gulu, Uganda. peace.amito@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23469585

Citation

Amito Florence, P, et al. "The Prevalence and Antibiotics Susceptibility Pattern of Neisseria Gonorrhoeae in Patients Attending OPD Clinics at St. Mary's Hospital Lacor Uganda." Journal of Preventive Medicine and Hygiene, vol. 53, no. 4, 2012, pp. 186-9.
Amito Florence P, Otim F, Okongo F, et al. The prevalence and antibiotics susceptibility pattern of Neisseria gonorrhoeae in patients attending OPD clinics at St. Mary's Hospital Lacor Uganda. J Prev Med Hyg. 2012;53(4):186-9.
Amito Florence, P., Otim, F., Okongo, F., Ogwang, M., & Greco, D. (2012). The prevalence and antibiotics susceptibility pattern of Neisseria gonorrhoeae in patients attending OPD clinics at St. Mary's Hospital Lacor Uganda. Journal of Preventive Medicine and Hygiene, 53(4), 186-9.
Amito Florence P, et al. The Prevalence and Antibiotics Susceptibility Pattern of Neisseria Gonorrhoeae in Patients Attending OPD Clinics at St. Mary's Hospital Lacor Uganda. J Prev Med Hyg. 2012;53(4):186-9. PubMed PMID: 23469585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence and antibiotics susceptibility pattern of Neisseria gonorrhoeae in patients attending OPD clinics at St. Mary's Hospital Lacor Uganda. AU - Amito Florence,P, AU - Otim,F, AU - Okongo,F, AU - Ogwang,M, AU - Greco,D, PY - 2013/3/9/entrez PY - 2013/3/9/pubmed PY - 2013/4/3/medline SP - 186 EP - 9 JF - Journal of preventive medicine and hygiene JO - J Prev Med Hyg VL - 53 IS - 4 N2 - INTRODUCTION: Gonorrhea is one of the most common sexually transmitted infections (STls) in developing countries, and the emergence of resistance to antimicrobial agents in Neisseria gonorrhoeae is a major obstacle in the control of gonorrhoea. Periodical determination of the prevalence and monitoring of antimicrobial susceptibility of N. gonorrhoeae is essential for the early detection of emergence of drug resistance. METHODS: A total of 640 consecutive patients who attended the Outpatient Department (OPD) Clinics at St. Mary's Hospital Lacor between Jan 2007-Dec 2011, with gonococcal urethriris symptoms and whose urethral swabs and high vagina swabs (HVS) were cultured, were involved in the study. Two hundred and fifty six (256) patients had positive pus swab culture, of which 151 (23.6%) showed growth of Neisseria gonorrhoeae. All the isolates were tested for antimicrobial susceptibility using the Kirby Bauer-disc diffusion techniques. RESULTS: Gonococcal isolates showed rapid decrease in susceptibility to the antimicrobials especially to ampicillin, tetracycline and erythomycin, ciprofloxacin, and intermediate to chloramphenicol, however, gentamicin and cefotaxime have remained as a single dose sensitive treatment for Neisseria gonorrhoeae. Sensitization on drug use and adopting preventive measures and continuous education on safer sexual behavior through health care authorities would lead to reduction in the prevalence of Neisseria gonorrhoeae and resistance to antimicrobial. DISCUSSION: Gonorrhea is one of the most common sexually transmitted infections (STIs) in developing countries, and the emergence of resistance to antimicrobial agents in Neisseria gonorrhoeae is a major obstacle in the control of gonorrhea. Periodical monitoring of antimicrobial susceptibility of N. gonorrhea is essential for the early detection of emergence of drug resistance. SN - 1121-2233 UR - https://www.unboundmedicine.com/medline/citation/23469585/The_prevalence_and_antibiotics_susceptibility_pattern_of_Neisseria_gonorrhoeae_in_patients_attending_OPD_clinics_at_St__Mary's_Hospital_Lacor_Uganda_ L2 - https://medlineplus.gov/gonorrhea.html DB - PRIME DP - Unbound Medicine ER -