Pd-catalyzed asymmetric allylic etherification using chiral biphenol-based diphosphinite ligands and its application for the formal total synthesis of (-)-galanthamine.J Org Chem. 2013 Apr 19; 78(8):4013-8.JO
Abstract
A library of novel chiral biphenol-based diphosphinite (BOP) ligands was designed and created. These BOP ligands were applied to a Pd-catalyzed intermolecular allylic etherification reaction, which provided a key intermediate for the formal total synthesis of (-)-galanthamine with 97% ee in 97% yield.
Links
Pub Type(s)
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Language
eng
PubMed ID
23472673
Citation
Zang, Yang, and Iwao Ojima. "Pd-catalyzed Asymmetric Allylic Etherification Using Chiral Biphenol-based Diphosphinite Ligands and Its Application for the Formal Total Synthesis of (-)-galanthamine." The Journal of Organic Chemistry, vol. 78, no. 8, 2013, pp. 4013-8.
Zang Y, Ojima I. Pd-catalyzed asymmetric allylic etherification using chiral biphenol-based diphosphinite ligands and its application for the formal total synthesis of (-)-galanthamine. J Org Chem. 2013;78(8):4013-8.
Zang, Y., & Ojima, I. (2013). Pd-catalyzed asymmetric allylic etherification using chiral biphenol-based diphosphinite ligands and its application for the formal total synthesis of (-)-galanthamine. The Journal of Organic Chemistry, 78(8), 4013-8. https://doi.org/10.1021/jo400355j
Zang Y, Ojima I. Pd-catalyzed Asymmetric Allylic Etherification Using Chiral Biphenol-based Diphosphinite Ligands and Its Application for the Formal Total Synthesis of (-)-galanthamine. J Org Chem. 2013 Apr 19;78(8):4013-8. PubMed PMID: 23472673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Pd-catalyzed asymmetric allylic etherification using chiral biphenol-based diphosphinite ligands and its application for the formal total synthesis of (-)-galanthamine.
AU - Zang,Yang,
AU - Ojima,Iwao,
Y1 - 2013/03/29/
PY - 2013/3/12/entrez
PY - 2013/3/12/pubmed
PY - 2013/8/13/medline
SP - 4013
EP - 8
JF - The Journal of organic chemistry
JO - J Org Chem
VL - 78
IS - 8
N2 - A library of novel chiral biphenol-based diphosphinite (BOP) ligands was designed and created. These BOP ligands were applied to a Pd-catalyzed intermolecular allylic etherification reaction, which provided a key intermediate for the formal total synthesis of (-)-galanthamine with 97% ee in 97% yield.
SN - 1520-6904
UR - https://www.unboundmedicine.com/medline/citation/23472673/Pd_catalyzed_asymmetric_allylic_etherification_using_chiral_biphenol_based_diphosphinite_ligands_and_its_application_for_the_formal_total_synthesis_of_____galanthamine_
L2 - https://doi.org/10.1021/jo400355j
DB - PRIME
DP - Unbound Medicine
ER -
