Tags

Type your tag names separated by a space and hit enter

Vitamin B12 deficiency and hyperhomocysteinemia as correlates of cardiovascular risk factors in Indian subjects with coronary artery disease.
J Cardiol. 2013 Apr; 61(4):289-94.JC

Abstract

BACKGROUND AND PURPOSE

Folate and vitamin B12 are essential components in the metabolism of homocysteine (Hcy). Hyperhomocysteinemia has been implicated in endothelial dysfunction and cardiovascular disease. However, the association of Hcy, vitamin B12, and folic acid with cardiovascular risk factors in patients with coronary artery disease (CAD) has not been studied in Indian patients. This study was conducted with the aim to evaluate the relationship of vitamin B12, folic acid, and Hcy levels with cardiovascular risk factors in subjects with known CAD.

METHODS AND SUBJECTS

Three hundred patients (216 men; 84 women; aged 25-92 years) who had CAD on angiography were included in this study consecutively. All patients were evaluated for anthropometry and cardiovascular risk factors, and blood samples were collected for biochemical, nutritional, and inflammatory markers.

RESULTS

Percentage of vitamin B12 and folate deficiency was 86.7% and 2.7%, respectively. Hyperhomocysteinemia was present in 95.3% patients. Vitamin B12 levels were significantly lower and Hcy levels were significantly higher in subjects with dyslipidemia, DM, and/or hypertension. Serum vitamin B12 was inversely associated with triglyceride and very low-density lipoprotein (VLDL) and positively with high-density lipoprotein (HDL). Hcy was positively associated with triglyceride and VLDL and negatively with HDL. Vitamin B12 was inversely correlated with inflammatory markers (high-sensitivity C-reactive protein and interleukin-6) directly related to insulin resistance whereas Hcy showed the opposite pattern.

CONCLUSIONS

Serum vitamin B12 deficiency and hyperhomocysteinemia are related with cardiovascular risk factors in Indian patients with CAD.

Authors+Show Affiliations

Deenanath Mangeshkar Hospital and Research Center, Biochemistry Section, Department of Pathology, Erandawane, Pune, India. pnmahalle@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23473764

Citation

Mahalle, Namita, et al. "Vitamin B12 Deficiency and Hyperhomocysteinemia as Correlates of Cardiovascular Risk Factors in Indian Subjects With Coronary Artery Disease." Journal of Cardiology, vol. 61, no. 4, 2013, pp. 289-94.
Mahalle N, Kulkarni MV, Garg MK, et al. Vitamin B12 deficiency and hyperhomocysteinemia as correlates of cardiovascular risk factors in Indian subjects with coronary artery disease. J Cardiol. 2013;61(4):289-94.
Mahalle, N., Kulkarni, M. V., Garg, M. K., & Naik, S. S. (2013). Vitamin B12 deficiency and hyperhomocysteinemia as correlates of cardiovascular risk factors in Indian subjects with coronary artery disease. Journal of Cardiology, 61(4), 289-94. https://doi.org/10.1016/j.jjcc.2012.11.009
Mahalle N, et al. Vitamin B12 Deficiency and Hyperhomocysteinemia as Correlates of Cardiovascular Risk Factors in Indian Subjects With Coronary Artery Disease. J Cardiol. 2013;61(4):289-94. PubMed PMID: 23473764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B12 deficiency and hyperhomocysteinemia as correlates of cardiovascular risk factors in Indian subjects with coronary artery disease. AU - Mahalle,Namita, AU - Kulkarni,Mohan V, AU - Garg,Mahendra K, AU - Naik,Sadanand S, Y1 - 2013/03/06/ PY - 2012/09/28/received PY - 2012/11/06/revised PY - 2012/11/29/accepted PY - 2013/3/12/entrez PY - 2013/3/12/pubmed PY - 2013/9/27/medline SP - 289 EP - 94 JF - Journal of cardiology JO - J Cardiol VL - 61 IS - 4 N2 - BACKGROUND AND PURPOSE: Folate and vitamin B12 are essential components in the metabolism of homocysteine (Hcy). Hyperhomocysteinemia has been implicated in endothelial dysfunction and cardiovascular disease. However, the association of Hcy, vitamin B12, and folic acid with cardiovascular risk factors in patients with coronary artery disease (CAD) has not been studied in Indian patients. This study was conducted with the aim to evaluate the relationship of vitamin B12, folic acid, and Hcy levels with cardiovascular risk factors in subjects with known CAD. METHODS AND SUBJECTS: Three hundred patients (216 men; 84 women; aged 25-92 years) who had CAD on angiography were included in this study consecutively. All patients were evaluated for anthropometry and cardiovascular risk factors, and blood samples were collected for biochemical, nutritional, and inflammatory markers. RESULTS: Percentage of vitamin B12 and folate deficiency was 86.7% and 2.7%, respectively. Hyperhomocysteinemia was present in 95.3% patients. Vitamin B12 levels were significantly lower and Hcy levels were significantly higher in subjects with dyslipidemia, DM, and/or hypertension. Serum vitamin B12 was inversely associated with triglyceride and very low-density lipoprotein (VLDL) and positively with high-density lipoprotein (HDL). Hcy was positively associated with triglyceride and VLDL and negatively with HDL. Vitamin B12 was inversely correlated with inflammatory markers (high-sensitivity C-reactive protein and interleukin-6) directly related to insulin resistance whereas Hcy showed the opposite pattern. CONCLUSIONS: Serum vitamin B12 deficiency and hyperhomocysteinemia are related with cardiovascular risk factors in Indian patients with CAD. SN - 1876-4738 UR - https://www.unboundmedicine.com/medline/citation/23473764/Vitamin_B12_deficiency_and_hyperhomocysteinemia_as_correlates_of_cardiovascular_risk_factors_in_Indian_subjects_with_coronary_artery_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0914-5087(13)00042-7 DB - PRIME DP - Unbound Medicine ER -