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Lacrimal gland sparing IgG4-related disease in the orbit.
Ocul Immunol Inflamm. 2013 Jun; 21(3):220-4.OI

Abstract

PURPOSE

We report an unusual case of orbital IgG4-related disease and discuss the distinguishing characteristics of the ophthalmic disease subtype.

DESIGN

Case report.

METHODS

Literature review and case description.

RESULTS

Although lacrimal gland involvement has always been reported and elevated serum IgG4 is commonly observed, our case demonstrated neither in light of biopsy-proven IgG4 orbital involvement. A course of systemic steroids resolved our patient's periorbital abnormalities.

CONCLUSIONS

IgG4-related orbital disease mandates a high index of suspicion, and should be confirmed by tissue biopsy. Possible progression to MALT lymphoma necessitates close surveillance and may require repeat biopsy.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Letter
Review

Language

eng

PubMed ID

23480602

Citation

Khan, Tanya T., et al. "Lacrimal Gland Sparing IgG4-related Disease in the Orbit." Ocular Immunology and Inflammation, vol. 21, no. 3, 2013, pp. 220-4.
Khan TT, Halat SK, Al Hariri AB. Lacrimal gland sparing IgG4-related disease in the orbit. Ocul Immunol Inflamm. 2013;21(3):220-4.
Khan, T. T., Halat, S. K., & Al Hariri, A. B. (2013). Lacrimal gland sparing IgG4-related disease in the orbit. Ocular Immunology and Inflammation, 21(3), 220-4. https://doi.org/10.3109/09273948.2012.762981
Khan TT, Halat SK, Al Hariri AB. Lacrimal Gland Sparing IgG4-related Disease in the Orbit. Ocul Immunol Inflamm. 2013;21(3):220-4. PubMed PMID: 23480602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lacrimal gland sparing IgG4-related disease in the orbit. AU - Khan,Tanya T, AU - Halat,Shams K, AU - Al Hariri,Adham B, Y1 - 2013/03/12/ PY - 2013/3/14/entrez PY - 2013/3/14/pubmed PY - 2014/2/5/medline SP - 220 EP - 4 JF - Ocular immunology and inflammation JO - Ocul. Immunol. Inflamm. VL - 21 IS - 3 N2 - PURPOSE: We report an unusual case of orbital IgG4-related disease and discuss the distinguishing characteristics of the ophthalmic disease subtype. DESIGN: Case report. METHODS: Literature review and case description. RESULTS: Although lacrimal gland involvement has always been reported and elevated serum IgG4 is commonly observed, our case demonstrated neither in light of biopsy-proven IgG4 orbital involvement. A course of systemic steroids resolved our patient's periorbital abnormalities. CONCLUSIONS: IgG4-related orbital disease mandates a high index of suspicion, and should be confirmed by tissue biopsy. Possible progression to MALT lymphoma necessitates close surveillance and may require repeat biopsy. SN - 1744-5078 UR - https://www.unboundmedicine.com/medline/citation/23480602/Lacrimal_gland_sparing_IgG4_related_disease_in_the_orbit_ L2 - http://www.tandfonline.com/doi/full/10.3109/09273948.2012.762981 DB - PRIME DP - Unbound Medicine ER -