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Prevalence of dyslipidemia among human immunodeficiency virus infected Nigerians.

Abstract

BACKGROUND

Dyslipidemia is a significant risk factor for premature cardiovascular disease. People infected with human immunodeficiency virus (HIV) have been shown to develop alterations in body composition, lipid and glucose metabolism, which predisposes them to cardiovascular disease. Human immunodeficiency virus (HIV) infection and its therapies may contribute to these changes. These metabolic changes in addition to the other traditional risk factors may contribute to the excess cardiovascular disease (CVD) morbidity and mortality observed in HIV-infected individuals. We, therefore set out to describe the prevalence of dyslipidemia among HIV infected Nigerians.

MATERIALS AND METHODS

This is a cross sectional study, was conducted in HIV specialty clinic of Aminu Kano Teaching Hospital (AKTH) between May and August 2009. HIV infected patients were recruited. Half of them were on HAART for 6 months and above while the other half were HAART naïve. Patients who satisfied inclusion criteria were recruited consecutively until the required sample size was obtained. Data were collected using the pre-tested interviewer administered questionnaire. Socio-demographic information, anthropometric measurements and blood pressure were obtained from the subjects in a standardized manner. Venous samples were collected for necessary investigations and analyzed at the hospital central laboratory.

RESULTS

Two hundred subjects were studied, the mean age for all the participants was 32.5 ± 7.55 years. The age ranged from 20 to 50 years, 64% of the respondents (128) were aged between 20 and 34 years. Forty three (21.5%) of them were above the age of 40 years. Fifty percent were on HAART and the other 50% were HAART naïve. The duration of HAART treatment ranged from 6-84 months. The mean CD4 cell counts was higher for subjects on HAART compared to HAART naive 376.33±215.66 and 261.09 ±195.64, respectively (P < 0.001). High TC (31% vs. 7%, P ≤ 0.001), low HDL-C (61% vs. 76%, P = 0.022), high LDL (36% vs. 26%, P = 0.126), high TG (19% vs. 13%, P = 0.247).

CONCLUSION

HIV infected patients on HAART demonstrated higher prevalence of high TC while HAART naïve subject showed higher prevalence of low HDL.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Federal Medical Centre Azare, Bauchi State, Nigeria.

    ,

    Source

    MeSH

    Adult
    Antiretroviral Therapy, Highly Active
    Blood Pressure
    Body Composition
    Body Mass Index
    CD4 Lymphocyte Count
    Cholesterol
    Cholesterol, HDL
    Cholesterol, LDL
    Cross-Sectional Studies
    Female
    HIV Infections
    Hospitals, Teaching
    Humans
    Hyperlipidemias
    Lipids
    Male
    Middle Aged
    Nigeria
    Prevalence
    Risk Factors
    Socioeconomic Factors
    Surveys and Questionnaires
    Triglycerides

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23480991

    Citation

    Muhammad, Sanusi, et al. "Prevalence of Dyslipidemia Among Human Immunodeficiency Virus Infected Nigerians." Annals of African Medicine, vol. 12, no. 1, 2013, pp. 24-8.
    Muhammad S, Sani MU, Okeahialam BN. Prevalence of dyslipidemia among human immunodeficiency virus infected Nigerians. Ann Afr Med. 2013;12(1):24-8.
    Muhammad, S., Sani, M. U., & Okeahialam, B. N. (2013). Prevalence of dyslipidemia among human immunodeficiency virus infected Nigerians. Annals of African Medicine, 12(1), pp. 24-8. doi:10.4103/1596-3519.108246.
    Muhammad S, Sani MU, Okeahialam BN. Prevalence of Dyslipidemia Among Human Immunodeficiency Virus Infected Nigerians. Ann Afr Med. 2013;12(1):24-8. PubMed PMID: 23480991.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prevalence of dyslipidemia among human immunodeficiency virus infected Nigerians. AU - Muhammad,Sanusi, AU - Sani,Mahmoud U, AU - Okeahialam,Basil N, PY - 2013/3/14/entrez PY - 2013/3/14/pubmed PY - 2013/8/13/medline SP - 24 EP - 8 JF - Annals of African medicine JO - Ann Afr Med VL - 12 IS - 1 N2 - BACKGROUND: Dyslipidemia is a significant risk factor for premature cardiovascular disease. People infected with human immunodeficiency virus (HIV) have been shown to develop alterations in body composition, lipid and glucose metabolism, which predisposes them to cardiovascular disease. Human immunodeficiency virus (HIV) infection and its therapies may contribute to these changes. These metabolic changes in addition to the other traditional risk factors may contribute to the excess cardiovascular disease (CVD) morbidity and mortality observed in HIV-infected individuals. We, therefore set out to describe the prevalence of dyslipidemia among HIV infected Nigerians. MATERIALS AND METHODS: This is a cross sectional study, was conducted in HIV specialty clinic of Aminu Kano Teaching Hospital (AKTH) between May and August 2009. HIV infected patients were recruited. Half of them were on HAART for 6 months and above while the other half were HAART naïve. Patients who satisfied inclusion criteria were recruited consecutively until the required sample size was obtained. Data were collected using the pre-tested interviewer administered questionnaire. Socio-demographic information, anthropometric measurements and blood pressure were obtained from the subjects in a standardized manner. Venous samples were collected for necessary investigations and analyzed at the hospital central laboratory. RESULTS: Two hundred subjects were studied, the mean age for all the participants was 32.5 ± 7.55 years. The age ranged from 20 to 50 years, 64% of the respondents (128) were aged between 20 and 34 years. Forty three (21.5%) of them were above the age of 40 years. Fifty percent were on HAART and the other 50% were HAART naïve. The duration of HAART treatment ranged from 6-84 months. The mean CD4 cell counts was higher for subjects on HAART compared to HAART naive 376.33±215.66 and 261.09 ±195.64, respectively (P < 0.001). High TC (31% vs. 7%, P ≤ 0.001), low HDL-C (61% vs. 76%, P = 0.022), high LDL (36% vs. 26%, P = 0.126), high TG (19% vs. 13%, P = 0.247). CONCLUSION: HIV infected patients on HAART demonstrated higher prevalence of high TC while HAART naïve subject showed higher prevalence of low HDL. SN - 0975-5764 UR - https://www.unboundmedicine.com/medline/citation/23480991/Prevalence_of_dyslipidemia_among_human_immunodeficiency_virus_infected_Nigerians_ L2 - http://www.annalsafrmed.org/article.asp?issn=1596-3519;year=2013;volume=12;issue=1;spage=24;epage=28;aulast=Muhammad DB - PRIME DP - Unbound Medicine ER -