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Critical points in ethylcellulose matrices: influence of the polymer, drug and filler properties.
Acta Pharm. 2013 Mar; 63(1):115-29.AP

Abstract

Percolation theory has been applied to study the drug release behaviour in multicomponent inert matrices containing ethylcellulose as a matrix forming polymer. Global influence of major formulation factors such as polymer viscosity, polymer particle size, drug and filler solubility and porosity of the tablets in drug release kinetics has been studied for the first time. Batches containing three viscosity grades of Ethocel™, microcrystalline cellulose (MCC) and lactose as fillers, a lubricant and flow aid mixture and three drugs with different solubility have been manufactured. For some batches, compression pressure was varied in order to obtain matrices with five levels of initial porosity. The behaviour of inert matrices was explained based on the percolation ranges of the main components of the formulation. The effect of the porosity percolation threshold was observed and the existence of a tricoherent drug-polymer-filler system is hypothesized.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Cifuentes C
Department of Pharmacyand Pharmaceutical TechnologyUniversity of Seville, Seville, Spain.
Aguilar-de-Leyva A
No affiliation info available
Rajabi-Siahboomi AR
No affiliation info available
Caraballo I
No affiliation info available

MeSH

CarbamazepineCelluloseChemistry, PharmaceuticalDiclofenacDrug CompoundingKineticsLactoseParticle SizePolymersPorosityPressureSolubilityTabletsVerapamilViscosity

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23482317

Citation

Cifuentes, Celia, et al. "Critical Points in Ethylcellulose Matrices: Influence of the Polymer, Drug and Filler Properties." Acta Pharmaceutica (Zagreb, Croatia), vol. 63, no. 1, 2013, pp. 115-29.
Cifuentes C, Aguilar-de-Leyva A, Rajabi-Siahboomi AR, et al. Critical points in ethylcellulose matrices: influence of the polymer, drug and filler properties. Acta Pharm. 2013;63(1):115-29.
Cifuentes, C., Aguilar-de-Leyva, A., Rajabi-Siahboomi, A. R., & Caraballo, I. (2013). Critical points in ethylcellulose matrices: influence of the polymer, drug and filler properties. Acta Pharmaceutica (Zagreb, Croatia), 63(1), 115-29. https://doi.org/10.2478/acph-2013-0005
Cifuentes C, et al. Critical Points in Ethylcellulose Matrices: Influence of the Polymer, Drug and Filler Properties. Acta Pharm. 2013;63(1):115-29. PubMed PMID: 23482317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Critical points in ethylcellulose matrices: influence of the polymer, drug and filler properties. AU - Cifuentes,Celia, AU - Aguilar-de-Leyva,Angela, AU - Rajabi-Siahboomi,Ali R, AU - Caraballo,Isidoro, PY - 2013/3/14/entrez PY - 2013/3/14/pubmed PY - 2013/11/20/medline SP - 115 EP - 29 JF - Acta pharmaceutica (Zagreb, Croatia) JO - Acta Pharm VL - 63 IS - 1 N2 - Percolation theory has been applied to study the drug release behaviour in multicomponent inert matrices containing ethylcellulose as a matrix forming polymer. Global influence of major formulation factors such as polymer viscosity, polymer particle size, drug and filler solubility and porosity of the tablets in drug release kinetics has been studied for the first time. Batches containing three viscosity grades of Ethocel™, microcrystalline cellulose (MCC) and lactose as fillers, a lubricant and flow aid mixture and three drugs with different solubility have been manufactured. For some batches, compression pressure was varied in order to obtain matrices with five levels of initial porosity. The behaviour of inert matrices was explained based on the percolation ranges of the main components of the formulation. The effect of the porosity percolation threshold was observed and the existence of a tricoherent drug-polymer-filler system is hypothesized. SN - 1846-9558 UR - https://www.unboundmedicine.com/medline/citation/23482317/Critical_points_in_ethylcellulose_matrices:_influence_of_the_polymer_drug_and_filler_properties_ DB - PRIME DP - Unbound Medicine ER -