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Epidemiologic evidence of superior outcomes for extramedullary plasmacytoma of the head and neck.
Otolaryngol Head Neck Surg. 2013 Jun; 148(6):974-81.OH

Abstract

OBJECTIVE

To compare clinicopathologic data, epidemiologic factors, and survival outcomes between extramedullary plasmacytomas of the head and neck vs other body sites.

STUDY DESIGN

Analysis of a national database.

SETTING

Extramedullary plasmacytoma (EMP) is a rare B-cell neoplasm with a tendency to occur in the head and neck. Due to limited clinical data, few studies have conducted a thorough comparison between head and neck EMPs and those arising at other body sites.

SUBJECTS AND METHODS

We compared 690 EMPs of the head and neck with 495 non-head and neck EMPs, evaluating disease-specific survival (DSS) and overall survival (OS) based on tumor type, location, grade, stage, and treatment.

RESULTS

Head and neck EMPs more often affected men (P > .001) and were typically located in the pharynx (21.5%), nasal cavity (19.3%), oral cavity (14.7%), and paranasal sinuses (13.0%). Non-head and neck EMPs were more often limited to only local disease at presentation (94.8% vs 82.1%-86.7%, P < .001). Patients with non-head and neck EMP more often received surgery alone, whereas those with head and neck EMP were more often treated with combination therapy or radiation alone (P < .001). Head and neck EMPs had a significantly higher 5-year DSS and OS than other plasmacytomas (P < .001), and they had a higher 10-year OS when treated with surgery or combination therapy than with radiation alone (P = .003).

CONCLUSION

Extramedullary plasmacytoma of the head and neck represents a type of tumor unique from other plasmacytomas, with distinct epidemiologic characteristics and a superior prognosis. Evidence suggests that surgically based treatments may offer improved outcomes.

Authors+Show Affiliations

Mercer University School of Medicine, Savannah, Georgia, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23482476

Citation

Gerry, Daniel, and Eric J. Lentsch. "Epidemiologic Evidence of Superior Outcomes for Extramedullary Plasmacytoma of the Head and Neck." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 148, no. 6, 2013, pp. 974-81.
Gerry D, Lentsch EJ. Epidemiologic evidence of superior outcomes for extramedullary plasmacytoma of the head and neck. Otolaryngol Head Neck Surg. 2013;148(6):974-81.
Gerry, D., & Lentsch, E. J. (2013). Epidemiologic evidence of superior outcomes for extramedullary plasmacytoma of the head and neck. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 148(6), 974-81. https://doi.org/10.1177/0194599813481334
Gerry D, Lentsch EJ. Epidemiologic Evidence of Superior Outcomes for Extramedullary Plasmacytoma of the Head and Neck. Otolaryngol Head Neck Surg. 2013;148(6):974-81. PubMed PMID: 23482476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiologic evidence of superior outcomes for extramedullary plasmacytoma of the head and neck. AU - Gerry,Daniel, AU - Lentsch,Eric J, Y1 - 2013/03/12/ PY - 2013/3/14/entrez PY - 2013/3/14/pubmed PY - 2013/7/23/medline KW - SEER database KW - extramedullary plasmacytoma KW - head and neck KW - solitary bone plasmacytoma SP - 974 EP - 81 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 148 IS - 6 N2 - OBJECTIVE: To compare clinicopathologic data, epidemiologic factors, and survival outcomes between extramedullary plasmacytomas of the head and neck vs other body sites. STUDY DESIGN: Analysis of a national database. SETTING: Extramedullary plasmacytoma (EMP) is a rare B-cell neoplasm with a tendency to occur in the head and neck. Due to limited clinical data, few studies have conducted a thorough comparison between head and neck EMPs and those arising at other body sites. SUBJECTS AND METHODS: We compared 690 EMPs of the head and neck with 495 non-head and neck EMPs, evaluating disease-specific survival (DSS) and overall survival (OS) based on tumor type, location, grade, stage, and treatment. RESULTS: Head and neck EMPs more often affected men (P > .001) and were typically located in the pharynx (21.5%), nasal cavity (19.3%), oral cavity (14.7%), and paranasal sinuses (13.0%). Non-head and neck EMPs were more often limited to only local disease at presentation (94.8% vs 82.1%-86.7%, P < .001). Patients with non-head and neck EMP more often received surgery alone, whereas those with head and neck EMP were more often treated with combination therapy or radiation alone (P < .001). Head and neck EMPs had a significantly higher 5-year DSS and OS than other plasmacytomas (P < .001), and they had a higher 10-year OS when treated with surgery or combination therapy than with radiation alone (P = .003). CONCLUSION: Extramedullary plasmacytoma of the head and neck represents a type of tumor unique from other plasmacytomas, with distinct epidemiologic characteristics and a superior prognosis. Evidence suggests that surgically based treatments may offer improved outcomes. SN - 1097-6817 UR - https://www.unboundmedicine.com/medline/citation/23482476/Epidemiologic_evidence_of_superior_outcomes_for_extramedullary_plasmacytoma_of_the_head_and_neck_ L2 - https://journals.sagepub.com/doi/10.1177/0194599813481334?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -