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Multifocal visual evoked potentials in unilateral compressive optic neuropathy secondary to orbital tumors.
Eur J Ophthalmol. 2013 Jul-Aug; 23(4):571-7.EJ

Abstract

OBJECTIVE

To evaluate the effects of unilateral compressive optic neuropathy secondary to orbital tumors and the removal of the tumors on amplitude and latency of multifocal visual evoked potentials (mfVEPs) and to compare these responses with visual field defects seen on static automated perimetry.

METHODS

Static automated and mfVEP recordings were obtained from 14 patients with orbital tumors affecting one optic nerve. Monocular and interocular amplitude and latency analyses were performed.

RESULTS

The change in the mfVEP amplitude agreed with visual field findings with regard to topography and severity of deviation from normal in 10 patients. For 4 patients with normal visual field, the changes in the mfVEP were of significance. The delay in recordable responses from affected eyes ranged from 2.56 to 18.28 ms (interocular analysis) and 0.1 to 21.86 ms (monocular analysis). Ten patients whose tumor was totally removed showed a recovery of the visual field and mfVEP to various degrees. Visual field of 6 patients showed within normal limits after total removal of the tumor, and the defects of mfVEP in 3 patients remained apparent, while the mfVEP of the other 3 patients showed a complete recovery.

CONCLUSIONS

Various orbital tumors can cause compressive optic neuropathy. Compressive optic neuropathy secondary to orbital tumors results in mfVEP amplitude reduction and latency prolongation. The changes in measures of mfVEP due to orbital tumors are consistent with the visual field changes in most patients. In some patients, the subjective visual field results and objective mfVEP are discordant. The objective changes of mfVEP may appear earlier than the defect of visual field, and thus it may be able to identify subtle defects that are undetectable with Humphrey perimetry. Postoperatively, recovery of the mfVEP may be later than that of visual field in some patients. The mfVEP changes may assist in both early diagnosis and follow-up of the compressive optic neuropathy secondary to orbital tumors.

Authors+Show Affiliations

Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23483502

Citation

Xue, Kang, et al. "Multifocal Visual Evoked Potentials in Unilateral Compressive Optic Neuropathy Secondary to Orbital Tumors." European Journal of Ophthalmology, vol. 23, no. 4, 2013, pp. 571-7.
Xue K, Wang M, Qian J, et al. Multifocal visual evoked potentials in unilateral compressive optic neuropathy secondary to orbital tumors. Eur J Ophthalmol. 2013;23(4):571-7.
Xue, K., Wang, M., Qian, J., Yuan, Y., & Zhang, R. (2013). Multifocal visual evoked potentials in unilateral compressive optic neuropathy secondary to orbital tumors. European Journal of Ophthalmology, 23(4), 571-7. https://doi.org/10.5301/ejo.5000262
Xue K, et al. Multifocal Visual Evoked Potentials in Unilateral Compressive Optic Neuropathy Secondary to Orbital Tumors. Eur J Ophthalmol. 2013 Jul-Aug;23(4):571-7. PubMed PMID: 23483502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multifocal visual evoked potentials in unilateral compressive optic neuropathy secondary to orbital tumors. AU - Xue,Kang, AU - Wang,Min, AU - Qian,Jiang, AU - Yuan,Yifei, AU - Zhang,Rui, Y1 - 2013/03/12/ PY - 2013/02/05/accepted PY - 2013/3/14/entrez PY - 2013/3/14/pubmed PY - 2014/2/20/medline SP - 571 EP - 7 JF - European journal of ophthalmology JO - Eur J Ophthalmol VL - 23 IS - 4 N2 - OBJECTIVE: To evaluate the effects of unilateral compressive optic neuropathy secondary to orbital tumors and the removal of the tumors on amplitude and latency of multifocal visual evoked potentials (mfVEPs) and to compare these responses with visual field defects seen on static automated perimetry. METHODS: Static automated and mfVEP recordings were obtained from 14 patients with orbital tumors affecting one optic nerve. Monocular and interocular amplitude and latency analyses were performed. RESULTS: The change in the mfVEP amplitude agreed with visual field findings with regard to topography and severity of deviation from normal in 10 patients. For 4 patients with normal visual field, the changes in the mfVEP were of significance. The delay in recordable responses from affected eyes ranged from 2.56 to 18.28 ms (interocular analysis) and 0.1 to 21.86 ms (monocular analysis). Ten patients whose tumor was totally removed showed a recovery of the visual field and mfVEP to various degrees. Visual field of 6 patients showed within normal limits after total removal of the tumor, and the defects of mfVEP in 3 patients remained apparent, while the mfVEP of the other 3 patients showed a complete recovery. CONCLUSIONS: Various orbital tumors can cause compressive optic neuropathy. Compressive optic neuropathy secondary to orbital tumors results in mfVEP amplitude reduction and latency prolongation. The changes in measures of mfVEP due to orbital tumors are consistent with the visual field changes in most patients. In some patients, the subjective visual field results and objective mfVEP are discordant. The objective changes of mfVEP may appear earlier than the defect of visual field, and thus it may be able to identify subtle defects that are undetectable with Humphrey perimetry. Postoperatively, recovery of the mfVEP may be later than that of visual field in some patients. The mfVEP changes may assist in both early diagnosis and follow-up of the compressive optic neuropathy secondary to orbital tumors. SN - 1724-6016 UR - https://www.unboundmedicine.com/medline/citation/23483502/Multifocal_visual_evoked_potentials_in_unilateral_compressive_optic_neuropathy_secondary_to_orbital_tumors_ DB - PRIME DP - Unbound Medicine ER -