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[Genetic polymorphisms of 18 STR loci in Uygur population of Kashi Prefecture of Xinjiang].
Fa Yi Xue Za Zhi. 2012 Dec; 28(6):451-5.FY

Abstract

OBJECTIVE

To investigate the genetic polymorphisms of 18 STR loci (D18S51, D21S11, D3S1358, FGA, D8S1179, upsilonWA, CSF1PO, D16S539, D7S820, D13S317, D5S818, D2S1338, D19S433, D12S391, TPOX, TH01, Penta E and D6S1043) in unrelated Uygur individuals in Kashi prefecture of Xinjiang and to explore the application value in forensic practice.

METHODS

Blood samples from 1 381 unrelated Uygur individuals were amplified by using DNA Typer 15 Plus kit. The amplified products were detected by using 3130XL Genetic Analyzer and the genotyping was done by using GeneMapper ID v3.2. Population genetics parameters were calculated and compared with that of the other population. The genetic distance of Reynold's was calculated and phylogenetic tree was constructed at last.

RESULTS

Of the 1 381 unrelated Uygur individuals, 231 alleles were detected, with an allele frequency of 0.0004-0.5304. The H values were 0.644-0.923, PIC values were 0.587-0.918, and DP values were 0.817-0.988, respectively, with a CPE > 0.9999999. The genetic distance was the longest (0.088 3) to Guangzhou Han population and the closest (0.0503) to Greek.

CONCLUSION

The 18 STR loci in the Uygur population of Kashi prefecture of Xinjiang have high genetic polymorphisms which are close to Europeans, and can be satisfied as genetic markers of population individual identification and paternity testing.

Authors+Show Affiliations

Zhang XH
Department of Forensic Medicine, Southern Medical University, Guangzhou 510515, China.
Li P
No affiliation info available
Weng WX
No affiliation info available
Liu CH
No affiliation info available
Liu H
No affiliation info available
Tang JX
No affiliation info available
Liu C
No affiliation info available

MeSH

Asian Continental Ancestry GroupChinaForensic GeneticsGene FrequencyGenetic LociGenetics, PopulationGenotypeHumansMicrosatellite RepeatsPolymerase Chain ReactionPolymorphism, Genetic

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

23484330

Citation

Zhang, Xiao-Hong, et al. "[Genetic Polymorphisms of 18 STR Loci in Uygur Population of Kashi Prefecture of Xinjiang]." Fa Yi Xue Za Zhi, vol. 28, no. 6, 2012, pp. 451-5.
Zhang XH, Li P, Weng WX, et al. [Genetic polymorphisms of 18 STR loci in Uygur population of Kashi Prefecture of Xinjiang]. Fa Yi Xue Za Zhi. 2012;28(6):451-5.
Zhang, X. H., Li, P., Weng, W. X., Liu, C. H., Liu, H., Tang, J. X., & Liu, C. (2012). [Genetic polymorphisms of 18 STR loci in Uygur population of Kashi Prefecture of Xinjiang]. Fa Yi Xue Za Zhi, 28(6), 451-5.
Zhang XH, et al. [Genetic Polymorphisms of 18 STR Loci in Uygur Population of Kashi Prefecture of Xinjiang]. Fa Yi Xue Za Zhi. 2012;28(6):451-5. PubMed PMID: 23484330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Genetic polymorphisms of 18 STR loci in Uygur population of Kashi Prefecture of Xinjiang]. AU - Zhang,Xiao-Hong, AU - Li,Ping, AU - Weng,Wei-Xia, AU - Liu,Chang-Hui, AU - Liu,Hong, AU - Tang,Jian-Xin, AU - Liu,Chao, PY - 2013/3/15/entrez PY - 2013/3/15/pubmed PY - 2013/9/13/medline SP - 451 EP - 5 JF - Fa yi xue za zhi JO - Fa Yi Xue Za Zhi VL - 28 IS - 6 N2 - OBJECTIVE: To investigate the genetic polymorphisms of 18 STR loci (D18S51, D21S11, D3S1358, FGA, D8S1179, upsilonWA, CSF1PO, D16S539, D7S820, D13S317, D5S818, D2S1338, D19S433, D12S391, TPOX, TH01, Penta E and D6S1043) in unrelated Uygur individuals in Kashi prefecture of Xinjiang and to explore the application value in forensic practice. METHODS: Blood samples from 1 381 unrelated Uygur individuals were amplified by using DNA Typer 15 Plus kit. The amplified products were detected by using 3130XL Genetic Analyzer and the genotyping was done by using GeneMapper ID v3.2. Population genetics parameters were calculated and compared with that of the other population. The genetic distance of Reynold's was calculated and phylogenetic tree was constructed at last. RESULTS: Of the 1 381 unrelated Uygur individuals, 231 alleles were detected, with an allele frequency of 0.0004-0.5304. The H values were 0.644-0.923, PIC values were 0.587-0.918, and DP values were 0.817-0.988, respectively, with a CPE > 0.9999999. The genetic distance was the longest (0.088 3) to Guangzhou Han population and the closest (0.0503) to Greek. CONCLUSION: The 18 STR loci in the Uygur population of Kashi prefecture of Xinjiang have high genetic polymorphisms which are close to Europeans, and can be satisfied as genetic markers of population individual identification and paternity testing. SN - 1004-5619 UR - https://www.unboundmedicine.com/medline/citation/23484330/[Genetic_polymorphisms_of_18_STR_loci_in_Uygur_population_of_Kashi_Prefecture_of_Xinjiang]_ L2 - https://antibodies.cancer.gov/detail/CPTC-CPE-1 DB - PRIME DP - Unbound Medicine ER -