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Regulation of intestinal homeostasis and immunity with probiotic lactobacilli.
Trends Immunol. 2013 May; 34(5):208-15.TI

Abstract

The gut microbiota provide important stimuli to the human innate and adaptive immune system and co-mediate metabolic and immune homeostasis. Probiotic bacteria can be regarded as part of the natural human microbiota, and have been associated with improving homeostasis, albeit with different levels of success. Composition of microbiota, probiotic strain identity, and host genetic differences may account for differential modulation of immune responses by probiotics. Here, we review the mechanisms of immunomodulating capacities of specific probiotic strains, the responses they can induce in the host, and how microbiota and genetic differences between individuals may co-influence host responses and immune homeostasis.

Authors+Show Affiliations

Host Microbe Interactomics Group, Wageningen University, De Elst 1, 6708WD Wageningen, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23485516

Citation

van Baarlen, Peter, et al. "Regulation of Intestinal Homeostasis and Immunity With Probiotic Lactobacilli." Trends in Immunology, vol. 34, no. 5, 2013, pp. 208-15.
van Baarlen P, Wells JM, Kleerebezem M. Regulation of intestinal homeostasis and immunity with probiotic lactobacilli. Trends Immunol. 2013;34(5):208-15.
van Baarlen, P., Wells, J. M., & Kleerebezem, M. (2013). Regulation of intestinal homeostasis and immunity with probiotic lactobacilli. Trends in Immunology, 34(5), 208-15. https://doi.org/10.1016/j.it.2013.01.005
van Baarlen P, Wells JM, Kleerebezem M. Regulation of Intestinal Homeostasis and Immunity With Probiotic Lactobacilli. Trends Immunol. 2013;34(5):208-15. PubMed PMID: 23485516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of intestinal homeostasis and immunity with probiotic lactobacilli. AU - van Baarlen,Peter, AU - Wells,Jerry M, AU - Kleerebezem,Michiel, Y1 - 2013/02/26/ PY - 2012/11/02/received PY - 2013/01/18/revised PY - 2013/01/22/accepted PY - 2013/3/15/entrez PY - 2013/3/15/pubmed PY - 2013/12/16/medline SP - 208 EP - 15 JF - Trends in immunology JO - Trends Immunol VL - 34 IS - 5 N2 - The gut microbiota provide important stimuli to the human innate and adaptive immune system and co-mediate metabolic and immune homeostasis. Probiotic bacteria can be regarded as part of the natural human microbiota, and have been associated with improving homeostasis, albeit with different levels of success. Composition of microbiota, probiotic strain identity, and host genetic differences may account for differential modulation of immune responses by probiotics. Here, we review the mechanisms of immunomodulating capacities of specific probiotic strains, the responses they can induce in the host, and how microbiota and genetic differences between individuals may co-influence host responses and immune homeostasis. SN - 1471-4981 UR - https://www.unboundmedicine.com/medline/citation/23485516/Regulation_of_intestinal_homeostasis_and_immunity_with_probiotic_lactobacilli_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4906(13)00014-8 DB - PRIME DP - Unbound Medicine ER -