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HLA-A, B (Class I) and HLA-DR, DQ (Class II) antigens in Turkish patients with recurrent aphthous ulceration and Behçet's disease.
Med Princ Pract. 2013; 22(5):464-8.MP

Abstract

OBJECTIVE

The aims of the present study were to typify the human leukocyte antigen system (HLA)-A, B (class I) and HLA-DR, DQ (class II) antigens and to assess the frequency of the presence of these antigens in the Turkish population with recurrent aphthous ulceration (RAU) and Behçet's disease (BD) compared to healthy subjects.

SUBJECTS AND METHODS

Thirty patients with RAU, 30 with BD, and 15 healthy subjects were included in the study. HLA typing was performed by serology with commercial kits for HLA class I and II (One Lambda, Canoga Park, Calif., USA).

RESULTS

The HLA-A23 frequency was 26.7% in the RAU patients, which was significantly higher than the 3.3% frequency in the patients with BD (p < 0.05). The HLA-A24 frequency was 33.3% in the RAU patient group, which was significantly higher (p < 0.05) than the frequency in the healthy subjects (6.7%). Significantly higher frequencies (46.7%) of HLA-A30 were found in the healthy subjects compared to the BD (13.3%) and RAU (3.3%) patients (p < 0.05 and p < 0.01, respectively). A higher frequency of HLA-B13 was observed in the RAU (23.3%) patients compared to the BD (0%) patients (p < 0.01). A decrease was observed in HLA-DR10 and HLA-DR17 in the RAU patients (p < 0.05), while a higher frequency of HLA-DR10 was observed in the BD patients compared to the RAU patients (p < 0.01).

CONCLUSIONS

These results showed that RAU and BD were not in the same spectrum and the involvement of other genetic and/or environmental factors might be responsible for the development of these diseases and/or disease progression.

Authors+Show Affiliations

Department of Oral Diagnosis and Radiology, Faculty of Dentistry, Marmara University Istanbul, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23485763

Citation

Pekiner, Filiz Namdar, et al. "HLA-A, B (Class I) and HLA-DR, DQ (Class II) Antigens in Turkish Patients With Recurrent Aphthous Ulceration and Behçet's Disease." Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, vol. 22, no. 5, 2013, pp. 464-8.
Pekiner FN, Aytugar E, Demirel GY, et al. HLA-A, B (Class I) and HLA-DR, DQ (Class II) antigens in Turkish patients with recurrent aphthous ulceration and Behçet's disease. Med Princ Pract. 2013;22(5):464-8.
Pekiner, F. N., Aytugar, E., Demirel, G. Y., & Borahan, M. O. (2013). HLA-A, B (Class I) and HLA-DR, DQ (Class II) antigens in Turkish patients with recurrent aphthous ulceration and Behçet's disease. Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, 22(5), 464-8. https://doi.org/10.1159/000348366
Pekiner FN, et al. HLA-A, B (Class I) and HLA-DR, DQ (Class II) Antigens in Turkish Patients With Recurrent Aphthous Ulceration and Behçet's Disease. Med Princ Pract. 2013;22(5):464-8. PubMed PMID: 23485763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-A, B (Class I) and HLA-DR, DQ (Class II) antigens in Turkish patients with recurrent aphthous ulceration and Behçet's disease. AU - Pekiner,Filiz Namdar, AU - Aytugar,Emre, AU - Demirel,Gülderen Yanikkaya, AU - Borahan,M Oğuz, Y1 - 2013/03/07/ PY - 2012/06/30/received PY - 2013/01/27/accepted PY - 2013/3/15/entrez PY - 2013/3/15/pubmed PY - 2014/5/6/medline SP - 464 EP - 8 JF - Medical principles and practice : international journal of the Kuwait University, Health Science Centre JO - Med Princ Pract VL - 22 IS - 5 N2 - OBJECTIVE: The aims of the present study were to typify the human leukocyte antigen system (HLA)-A, B (class I) and HLA-DR, DQ (class II) antigens and to assess the frequency of the presence of these antigens in the Turkish population with recurrent aphthous ulceration (RAU) and Behçet's disease (BD) compared to healthy subjects. SUBJECTS AND METHODS: Thirty patients with RAU, 30 with BD, and 15 healthy subjects were included in the study. HLA typing was performed by serology with commercial kits for HLA class I and II (One Lambda, Canoga Park, Calif., USA). RESULTS: The HLA-A23 frequency was 26.7% in the RAU patients, which was significantly higher than the 3.3% frequency in the patients with BD (p < 0.05). The HLA-A24 frequency was 33.3% in the RAU patient group, which was significantly higher (p < 0.05) than the frequency in the healthy subjects (6.7%). Significantly higher frequencies (46.7%) of HLA-A30 were found in the healthy subjects compared to the BD (13.3%) and RAU (3.3%) patients (p < 0.05 and p < 0.01, respectively). A higher frequency of HLA-B13 was observed in the RAU (23.3%) patients compared to the BD (0%) patients (p < 0.01). A decrease was observed in HLA-DR10 and HLA-DR17 in the RAU patients (p < 0.05), while a higher frequency of HLA-DR10 was observed in the BD patients compared to the RAU patients (p < 0.01). CONCLUSIONS: These results showed that RAU and BD were not in the same spectrum and the involvement of other genetic and/or environmental factors might be responsible for the development of these diseases and/or disease progression. SN - 1423-0151 UR - https://www.unboundmedicine.com/medline/citation/23485763/HLA_A_B__Class_I__and_HLA_DR_DQ__Class_II__antigens_in_Turkish_patients_with_recurrent_aphthous_ulceration_and_Behçet's_disease_ L2 - https://www.karger.com?DOI=10.1159/000348366 DB - PRIME DP - Unbound Medicine ER -