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Checking for completeness of 24-h urine collection using para-amino benzoic acid not necessary in the Observing Protein and Energy Nutrition study.
Eur J Clin Nutr. 2013 Aug; 67(8):863-7.EJ

Abstract

BACKGROUND/OBJECTIVES

The orally administered para-amino benzoic acid (PABA) is known to have near 100% excretion in urine and is used as a measure of 24-h urine collection completeness (referred to as PABAcheck). The purpose was to examine the effect of including urine collections deemed incomplete based on PABAcheck in a dietary measurement error study.

SUBJECTS/METHODS

The Observing Protein and Energy Nutrition (OPEN) study was conducted in 1999-2000 and included 484 men and women aged 40-69 years. A food frequency questionnaire and 24-h dietary recalls were evaluated using recovery biomarkers that included urinary nitrogen and potassium from two 24-h urine collections. Statistical modeling determined the measurement error properties of dietary assessment instruments. In the original analyses, PABAcheck was used as a measure of complete urine collection; incomplete collections were either excluded or adjusted to acceptable levels. The OPEN data were reanalyzed including all urine collections and by using criteria based on self-reported missing voids to assess the differences.

RESULTS

Means and coefficients of variation for biomarker-based protein and potassium intakes, and measurement error model-based correlations and attenuation factors were similar regardless of whether PABAcheck or missed voids were considered.

CONCLUSION

PABAcheck may not be required in large population-based biomarker studies. However, until there are more analyses evaluating the necessity of a PABAcheck, it is recommended that PABA be given to all participants, but not necessarily analyzed. Then, PABAcheck could be used selectively as a marker of completeness among the collections in which low levels of biomarker are detected or for which noncompliance is suspected.

Authors+Show Affiliations

Division of Cancer Control and Population Sciences, US National Cancer Institute, Bethesda, MD 20892-7344, USA. subara@mail.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23486508

Citation

Subar, A F., et al. "Checking for Completeness of 24-h Urine Collection Using Para-amino Benzoic Acid Not Necessary in the Observing Protein and Energy Nutrition Study." European Journal of Clinical Nutrition, vol. 67, no. 8, 2013, pp. 863-7.
Subar AF, Midthune D, Tasevska N, et al. Checking for completeness of 24-h urine collection using para-amino benzoic acid not necessary in the Observing Protein and Energy Nutrition study. Eur J Clin Nutr. 2013;67(8):863-7.
Subar, A. F., Midthune, D., Tasevska, N., Kipnis, V., & Freedman, L. S. (2013). Checking for completeness of 24-h urine collection using para-amino benzoic acid not necessary in the Observing Protein and Energy Nutrition study. European Journal of Clinical Nutrition, 67(8), 863-7. https://doi.org/10.1038/ejcn.2013.62
Subar AF, et al. Checking for Completeness of 24-h Urine Collection Using Para-amino Benzoic Acid Not Necessary in the Observing Protein and Energy Nutrition Study. Eur J Clin Nutr. 2013;67(8):863-7. PubMed PMID: 23486508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Checking for completeness of 24-h urine collection using para-amino benzoic acid not necessary in the Observing Protein and Energy Nutrition study. AU - Subar,A F, AU - Midthune,D, AU - Tasevska,N, AU - Kipnis,V, AU - Freedman,L S, Y1 - 2013/03/13/ PY - 2012/10/01/received PY - 2013/02/05/revised PY - 2013/02/08/accepted PY - 2013/3/15/entrez PY - 2013/3/15/pubmed PY - 2014/2/22/medline SP - 863 EP - 7 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 67 IS - 8 N2 - BACKGROUND/OBJECTIVES: The orally administered para-amino benzoic acid (PABA) is known to have near 100% excretion in urine and is used as a measure of 24-h urine collection completeness (referred to as PABAcheck). The purpose was to examine the effect of including urine collections deemed incomplete based on PABAcheck in a dietary measurement error study. SUBJECTS/METHODS: The Observing Protein and Energy Nutrition (OPEN) study was conducted in 1999-2000 and included 484 men and women aged 40-69 years. A food frequency questionnaire and 24-h dietary recalls were evaluated using recovery biomarkers that included urinary nitrogen and potassium from two 24-h urine collections. Statistical modeling determined the measurement error properties of dietary assessment instruments. In the original analyses, PABAcheck was used as a measure of complete urine collection; incomplete collections were either excluded or adjusted to acceptable levels. The OPEN data were reanalyzed including all urine collections and by using criteria based on self-reported missing voids to assess the differences. RESULTS: Means and coefficients of variation for biomarker-based protein and potassium intakes, and measurement error model-based correlations and attenuation factors were similar regardless of whether PABAcheck or missed voids were considered. CONCLUSION: PABAcheck may not be required in large population-based biomarker studies. However, until there are more analyses evaluating the necessity of a PABAcheck, it is recommended that PABA be given to all participants, but not necessarily analyzed. Then, PABAcheck could be used selectively as a marker of completeness among the collections in which low levels of biomarker are detected or for which noncompliance is suspected. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/23486508/Checking_for_completeness_of_24_h_urine_collection_using_para_amino_benzoic_acid_not_necessary_in_the_Observing_Protein_and_Energy_Nutrition_study_ L2 - https://doi.org/10.1038/ejcn.2013.62 DB - PRIME DP - Unbound Medicine ER -