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Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies.
Kidney Int. 2013 Jul; 84(1):179-91.KI

Abstract

Prevalence estimates of depression in chronic kidney disease (CKD) vary widely in existing studies. We conducted a systematic review and meta-analysis of observational studies to summarize the point prevalence of depressive symptoms in adults with CKD. We searched MEDLINE and Embase (through January 2012). Random-effects meta-analysis was used to estimate the prevalence of depressive symptoms. We also limited the analyses to studies using clinical interview and prespecified criteria for diagnosis. We included 249 populations (55,982 participants). Estimated prevalence of depression varied by stage of CKD and the tools used for diagnosis. Prevalence of interview-based depression in CKD stage 5D was 22.8% (confidence interval (CI), 18.6-27.6), but estimates were somewhat less precise for CKD stages 1-5 (21.4% (CI, 11.1-37.2)) and for kidney transplant recipients (25.7% (12.8-44.9)). Using self- or clinician-administered rating scales, the prevalence of depressive symptoms for CKD stage 5D was higher (39.3% (CI, 36.8-42.0)) relative to CKD stages 1-5 (26.5% (CI, 18.5-36.5)) and transplant recipients (26.6% (CI, 20.9-33.1)) and suggested that self-report scales may overestimate the presence of depression, particularly in the dialysis setting. Thus, interview-defined depression affects approximately one-quarter of adults with CKD. Given the potential prevalence of depression in the setting of CKD, randomized trials to evaluate effects of interventions for depression on patient-centered outcomes are needed.

Authors+Show Affiliations

Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

23486521

Citation

Palmer, Suetonia, et al. "Prevalence of Depression in Chronic Kidney Disease: Systematic Review and Meta-analysis of Observational Studies." Kidney International, vol. 84, no. 1, 2013, pp. 179-91.
Palmer S, Vecchio M, Craig JC, et al. Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies. Kidney Int. 2013;84(1):179-91.
Palmer, S., Vecchio, M., Craig, J. C., Tonelli, M., Johnson, D. W., Nicolucci, A., Pellegrini, F., Saglimbene, V., Logroscino, G., Fishbane, S., & Strippoli, G. F. (2013). Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies. Kidney International, 84(1), 179-91. https://doi.org/10.1038/ki.2013.77
Palmer S, et al. Prevalence of Depression in Chronic Kidney Disease: Systematic Review and Meta-analysis of Observational Studies. Kidney Int. 2013;84(1):179-91. PubMed PMID: 23486521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies. AU - Palmer,Suetonia, AU - Vecchio,Mariacristina, AU - Craig,Jonathan C, AU - Tonelli,Marcello, AU - Johnson,David W, AU - Nicolucci,Antonio, AU - Pellegrini,Fabio, AU - Saglimbene,Valeria, AU - Logroscino,Giancarlo, AU - Fishbane,Steven, AU - Strippoli,Giovanni F M, Y1 - 2013/03/13/ PY - 2012/07/09/received PY - 2012/12/25/revised PY - 2013/01/03/accepted PY - 2013/3/15/entrez PY - 2013/3/15/pubmed PY - 2014/4/23/medline SP - 179 EP - 91 JF - Kidney international JO - Kidney Int VL - 84 IS - 1 N2 - Prevalence estimates of depression in chronic kidney disease (CKD) vary widely in existing studies. We conducted a systematic review and meta-analysis of observational studies to summarize the point prevalence of depressive symptoms in adults with CKD. We searched MEDLINE and Embase (through January 2012). Random-effects meta-analysis was used to estimate the prevalence of depressive symptoms. We also limited the analyses to studies using clinical interview and prespecified criteria for diagnosis. We included 249 populations (55,982 participants). Estimated prevalence of depression varied by stage of CKD and the tools used for diagnosis. Prevalence of interview-based depression in CKD stage 5D was 22.8% (confidence interval (CI), 18.6-27.6), but estimates were somewhat less precise for CKD stages 1-5 (21.4% (CI, 11.1-37.2)) and for kidney transplant recipients (25.7% (12.8-44.9)). Using self- or clinician-administered rating scales, the prevalence of depressive symptoms for CKD stage 5D was higher (39.3% (CI, 36.8-42.0)) relative to CKD stages 1-5 (26.5% (CI, 18.5-36.5)) and transplant recipients (26.6% (CI, 20.9-33.1)) and suggested that self-report scales may overestimate the presence of depression, particularly in the dialysis setting. Thus, interview-defined depression affects approximately one-quarter of adults with CKD. Given the potential prevalence of depression in the setting of CKD, randomized trials to evaluate effects of interventions for depression on patient-centered outcomes are needed. SN - 1523-1755 UR - https://www.unboundmedicine.com/medline/citation/23486521/Prevalence_of_depression_in_chronic_kidney_disease:_systematic_review_and_meta_analysis_of_observational_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0085-2538(15)55927-9 DB - PRIME DP - Unbound Medicine ER -