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Influence of simethicone and alverine on stress-induced alterations of colonic permeability and sensitivity in rats: beneficial effect of their association.
J Pharm Pharmacol. 2013 Apr; 65(4):567-73.JP

Abstract

OBJECTIVES

Alverine, an antispasmodic agent for the treatment of irritable bowel syndrome (IBS), may be combined with simethicone, a protective agent of the mucosa. Stress is a major factor triggering abdominal pain in IBS and causing hypersensitivity to colonic distension in animals through an increased colonic permeability. The antinociceptive effects of alverine and simethicone, separately or in association, were evaluated on stress-induced colonic hypersensitivity to distension in rats. The influence of simethicone on altered permeability was also tested.

METHODS

Groups of 8-10 female adult Wistar rats (200-250 g) housed individually were used. Gut paracellular permeability was evaluated after 2 h of partial restraint stress using oral gavage with ⁵¹Cr-EDTA and 24 h of urine collection. The number of abdominal cramps during colonic distension was evaluated in animals equipped with electrodes on their abdominal striated muscles.

KEY FINDINGS

At 200 mg/kg p.o. twice a day, but not at lower doses, simethicone reduced stress-induced increase of colonic permeability and hypersensitivity to distension. Administered alone at 10 mg/kg p.o., alverine also reduced stress-induced hypersensitivity to distension; lower doses were inactive. However, alverine administered at an inactive dose with simethicone suppressed stress-induced hypersensitivity to distension.

CONCLUSIONS

We conclude that both simethicone and alverine have visceral antinociceptive effects by two different mechanisms and that simethicone exerts a potentiating effect on the antinociceptive action of alverine.

Authors+Show Affiliations

Department of Neurogastroenterology, Toxalim- INRA, Toulouse, France. lbueno@toulouse.inra.frNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23488786

Citation

Bueno, Lionel, et al. "Influence of Simethicone and Alverine On Stress-induced Alterations of Colonic Permeability and Sensitivity in Rats: Beneficial Effect of Their Association." The Journal of Pharmacy and Pharmacology, vol. 65, no. 4, 2013, pp. 567-73.
Bueno L, Beaufrand C, Theodorou V, et al. Influence of simethicone and alverine on stress-induced alterations of colonic permeability and sensitivity in rats: beneficial effect of their association. J Pharm Pharmacol. 2013;65(4):567-73.
Bueno, L., Beaufrand, C., Theodorou, V., & Andro-Delestrain, M. C. (2013). Influence of simethicone and alverine on stress-induced alterations of colonic permeability and sensitivity in rats: beneficial effect of their association. The Journal of Pharmacy and Pharmacology, 65(4), 567-73. https://doi.org/10.1111/jphp.12021
Bueno L, et al. Influence of Simethicone and Alverine On Stress-induced Alterations of Colonic Permeability and Sensitivity in Rats: Beneficial Effect of Their Association. J Pharm Pharmacol. 2013;65(4):567-73. PubMed PMID: 23488786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of simethicone and alverine on stress-induced alterations of colonic permeability and sensitivity in rats: beneficial effect of their association. AU - Bueno,Lionel, AU - Beaufrand,Catherine, AU - Theodorou,Vassilia, AU - Andro-Delestrain,Marie-Christine, Y1 - 2013/01/17/ PY - 2012/05/04/received PY - 2012/11/30/accepted PY - 2013/3/16/entrez PY - 2013/3/16/pubmed PY - 2013/9/21/medline SP - 567 EP - 73 JF - The Journal of pharmacy and pharmacology JO - J Pharm Pharmacol VL - 65 IS - 4 N2 - OBJECTIVES: Alverine, an antispasmodic agent for the treatment of irritable bowel syndrome (IBS), may be combined with simethicone, a protective agent of the mucosa. Stress is a major factor triggering abdominal pain in IBS and causing hypersensitivity to colonic distension in animals through an increased colonic permeability. The antinociceptive effects of alverine and simethicone, separately or in association, were evaluated on stress-induced colonic hypersensitivity to distension in rats. The influence of simethicone on altered permeability was also tested. METHODS: Groups of 8-10 female adult Wistar rats (200-250 g) housed individually were used. Gut paracellular permeability was evaluated after 2 h of partial restraint stress using oral gavage with ⁵¹Cr-EDTA and 24 h of urine collection. The number of abdominal cramps during colonic distension was evaluated in animals equipped with electrodes on their abdominal striated muscles. KEY FINDINGS: At 200 mg/kg p.o. twice a day, but not at lower doses, simethicone reduced stress-induced increase of colonic permeability and hypersensitivity to distension. Administered alone at 10 mg/kg p.o., alverine also reduced stress-induced hypersensitivity to distension; lower doses were inactive. However, alverine administered at an inactive dose with simethicone suppressed stress-induced hypersensitivity to distension. CONCLUSIONS: We conclude that both simethicone and alverine have visceral antinociceptive effects by two different mechanisms and that simethicone exerts a potentiating effect on the antinociceptive action of alverine. SN - 2042-7158 UR - https://www.unboundmedicine.com/medline/citation/23488786/Influence_of_simethicone_and_alverine_on_stress_induced_alterations_of_colonic_permeability_and_sensitivity_in_rats:_beneficial_effect_of_their_association_ L2 - https://doi.org/10.1111/jphp.12021 DB - PRIME DP - Unbound Medicine ER -