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The skin microbiome: current perspectives and future challenges.

Abstract

Complex communities of bacteria, fungi, and viruses thrive on our skin. The composition of these communities depends on skin characteristics, such as sebaceous gland concentration, moisture content, and temperature, as well as on host genetics and exogenous environmental factors. Recent metagenomic studies have uncovered a surprising diversity within these ecosystems and have fostered a new view of commensal organisms as playing a much larger role in immune modulation and epithelial health than previously expected. Understanding microbe-host interactions and discovering the factors that drive microbial colonization will help us understand the pathogenesis of skin diseases and develop new promicrobial and antimicrobial therapeutics.

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  • Authors+Show Affiliations

    ,

    Medical Scientist Training Program, Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts, USA.

    Source

    MeSH

    Animals
    Colony Count, Microbial
    Dermatitis, Atopic
    Humans
    Immunity, Innate
    Metagenome
    Nucleic Acid Amplification Techniques
    RNA, Ribosomal, 16S
    Skin
    Skin Diseases, Infectious
    Skin Neoplasms

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    23489584

    Citation

    Chen, Yiyin Erin, and Hensin Tsao. "The Skin Microbiome: Current Perspectives and Future Challenges." Journal of the American Academy of Dermatology, vol. 69, no. 1, 2013, pp. 143-55.
    Chen YE, Tsao H. The skin microbiome: current perspectives and future challenges. J Am Acad Dermatol. 2013;69(1):143-55.
    Chen, Y. E., & Tsao, H. (2013). The skin microbiome: current perspectives and future challenges. Journal of the American Academy of Dermatology, 69(1), pp. 143-55. doi:10.1016/j.jaad.2013.01.016.
    Chen YE, Tsao H. The Skin Microbiome: Current Perspectives and Future Challenges. J Am Acad Dermatol. 2013;69(1):143-55. PubMed PMID: 23489584.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The skin microbiome: current perspectives and future challenges. AU - Chen,Yiyin Erin, AU - Tsao,Hensin, Y1 - 2013/03/13/ PY - 2012/09/03/received PY - 2012/12/19/revised PY - 2013/01/06/accepted PY - 2013/3/16/entrez PY - 2013/3/16/pubmed PY - 2013/8/28/medline SP - 143 EP - 55 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 69 IS - 1 N2 - Complex communities of bacteria, fungi, and viruses thrive on our skin. The composition of these communities depends on skin characteristics, such as sebaceous gland concentration, moisture content, and temperature, as well as on host genetics and exogenous environmental factors. Recent metagenomic studies have uncovered a surprising diversity within these ecosystems and have fostered a new view of commensal organisms as playing a much larger role in immune modulation and epithelial health than previously expected. Understanding microbe-host interactions and discovering the factors that drive microbial colonization will help us understand the pathogenesis of skin diseases and develop new promicrobial and antimicrobial therapeutics. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/23489584/The_skin_microbiome:_current_perspectives_and_future_challenges_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(13)00076-5 DB - PRIME DP - Unbound Medicine ER -