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Lack of evidence of hepatitis E virus infection among renal transplant recipients in a disease-endemic area.
J Viral Hepat. 2013 Apr; 20(4):e138-40.JV

Abstract

Persistent hepatitis E virus (HEV) infection has been reported among solid-organ transplant recipients in nonendemic areas. Such chronic infections have all been related to genotype 3 HEV, which is prevalent in these areas. Whether persistent infection occurs with genotype 1 HEV, prevalent in areas where the infection is hyperendemic, is unclear. We therefore tested sera from renal transplant recipients receiving immunosuppressive agents in India, where genotype 1 HEV infection is endemic, for alanine aminotransferase levels, and presence of IgM and IgG anti-HEV antibodies and HEV RNA. Of the 205 subjects studied [aged 16-65 (median, 38) years, 182 male], 46 (22.4%) had abnormal ALT levels (>40 IU/mL). IgG anti-HEV was detected in 52 (20.5%) and IgM anti-HEV was detected in 14 (6.8%) subjects, including four who had IgG anti-HEV; antibody positivity had no relation with serum ALT or serum creatinine. All the sera tested were negative for HEV RNA. These findings suggest that chronic infection with genotype 1 HEV is infrequent.

Authors+Show Affiliations

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23490383

Citation

Naik, A, et al. "Lack of Evidence of Hepatitis E Virus Infection Among Renal Transplant Recipients in a Disease-endemic Area." Journal of Viral Hepatitis, vol. 20, no. 4, 2013, pp. e138-40.
Naik A, Gupta N, Goel D, et al. Lack of evidence of hepatitis E virus infection among renal transplant recipients in a disease-endemic area. J Viral Hepat. 2013;20(4):e138-40.
Naik, A., Gupta, N., Goel, D., Ippagunta, S. K., Sharma, R. K., & Aggarwal, R. (2013). Lack of evidence of hepatitis E virus infection among renal transplant recipients in a disease-endemic area. Journal of Viral Hepatitis, 20(4), e138-40. https://doi.org/10.1111/jvh.12027
Naik A, et al. Lack of Evidence of Hepatitis E Virus Infection Among Renal Transplant Recipients in a Disease-endemic Area. J Viral Hepat. 2013;20(4):e138-40. PubMed PMID: 23490383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of evidence of hepatitis E virus infection among renal transplant recipients in a disease-endemic area. AU - Naik,A, AU - Gupta,N, AU - Goel,D, AU - Ippagunta,S K, AU - Sharma,R K, AU - Aggarwal,R, Y1 - 2012/11/26/ PY - 2012/07/01/received PY - 2012/09/01/accepted PY - 2013/3/16/entrez PY - 2013/3/16/pubmed PY - 2013/8/29/medline SP - e138 EP - 40 JF - Journal of viral hepatitis JO - J Viral Hepat VL - 20 IS - 4 N2 - Persistent hepatitis E virus (HEV) infection has been reported among solid-organ transplant recipients in nonendemic areas. Such chronic infections have all been related to genotype 3 HEV, which is prevalent in these areas. Whether persistent infection occurs with genotype 1 HEV, prevalent in areas where the infection is hyperendemic, is unclear. We therefore tested sera from renal transplant recipients receiving immunosuppressive agents in India, where genotype 1 HEV infection is endemic, for alanine aminotransferase levels, and presence of IgM and IgG anti-HEV antibodies and HEV RNA. Of the 205 subjects studied [aged 16-65 (median, 38) years, 182 male], 46 (22.4%) had abnormal ALT levels (>40 IU/mL). IgG anti-HEV was detected in 52 (20.5%) and IgM anti-HEV was detected in 14 (6.8%) subjects, including four who had IgG anti-HEV; antibody positivity had no relation with serum ALT or serum creatinine. All the sera tested were negative for HEV RNA. These findings suggest that chronic infection with genotype 1 HEV is infrequent. SN - 1365-2893 UR - https://www.unboundmedicine.com/medline/citation/23490383/Lack_of_evidence_of_hepatitis_E_virus_infection_among_renal_transplant_recipients_in_a_disease_endemic_area_ L2 - https://doi.org/10.1111/jvh.12027 DB - PRIME DP - Unbound Medicine ER -