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Propofol and thiopental as anesthetic agents in electroconvulsive therapy: a retrospective study in major depression.
Rev Psiquiatr Salud Ment. 2014 Jan-Mar; 7(1):42-7.RP

Abstract

OBJECTIVE

To determine the influence of propofol and thiopental as anesthetics in electroconvulsive therapy (ECT), as regards, seizure duration, electrical charge, clinical efficacy, cardiovascular profile, and presence of adverse cognitive effects.

METHODS

A retrospective design including 127 patients who received bilateral ECT for the treatment of a major depressive episode.

RESULTS

The mean seizure duration in the propofol group was significantly shorter than in the thiopental group (21.23±6.09 versus 28.24±6.6 7s, P<.001). The mean stimulus charge was 348.22 mC in the propofol group, and 238 mC in the thiopental group (P<.001). Propofol was associated with a lower increase in blood pressure. There were no differences between groups in treatment response or presence of adverse effects.

CONCLUSIONS

The anesthetic agent used in ECT might determine differences in parameters such as seizure duration or electrical charge. However, this does not seem to be translated into differences in clinical efficacy or the pattern of adverse effects observed.

Authors+Show Affiliations

Salut Mental Parc Taulí, Corporació Sanitària Universitària Parc Taulí, Sabadell, Institut Universitari Parc Taulí - UAB (IUFPT-UAB), España. Electronic address: emartineza@tauli.cat.Grupo de Neurociencias [Institut Recerca Biomèdica Bellvitge] IDIBELL, Unidad clínica e investigación de trastornos afectivos, Servicio de Psiquiatría, Hospital Universitari de Bellvitge-ICS, L'Hospitalet de Llobregat, Universitat de Barcelona, Barcelona, España.Salut Mental Parc Taulí, Corporació Sanitària Universitària Parc Taulí, Sabadell, Institut Universitari Parc Taulí - UAB (IUFPT-UAB), España.Salut Mental Parc Taulí, Corporació Sanitària Universitària Parc Taulí, Sabadell, Institut Universitari Parc Taulí - UAB (IUFPT-UAB), España.Grupo de Neurociencias [Institut Recerca Biomèdica Bellvitge] IDIBELL, Unidad clínica e investigación de trastornos afectivos, Servicio de Psiquiatría, Hospital Universitari de Bellvitge-ICS, L'Hospitalet de Llobregat, Universitat de Barcelona, Barcelona, España.Salut Mental Parc Taulí, Corporació Sanitària Universitària Parc Taulí, Sabadell, Institut Universitari Parc Taulí - UAB (IUFPT-UAB), España.Grupo de Neurociencias [Institut Recerca Biomèdica Bellvitge] IDIBELL, Unidad clínica e investigación de trastornos afectivos, Servicio de Psiquiatría, Hospital Universitari de Bellvitge-ICS, L'Hospitalet de Llobregat, Universitat de Barcelona, Barcelona, España; Cibersam (CIBER en Salud Mental), Barcelona, España.Grupo de Neurociencias [Institut Recerca Biomèdica Bellvitge] IDIBELL, Unidad clínica e investigación de trastornos afectivos, Servicio de Psiquiatría, Hospital Universitari de Bellvitge-ICS, L'Hospitalet de Llobregat, Universitat de Barcelona, Barcelona, España; Cibersam (CIBER en Salud Mental), Barcelona, España.

Pub Type(s)

Comparative Study
Journal Article

Language

eng spa

PubMed ID

23490495

Citation

Martínez-Amorós, Erika, et al. "Propofol and Thiopental as Anesthetic Agents in Electroconvulsive Therapy: a Retrospective Study in Major Depression." Revista De Psiquiatria Y Salud Mental, vol. 7, no. 1, 2014, pp. 42-7.
Martínez-Amorós E, Gálvez Ortiz V, Porter Moli M, et al. Propofol and thiopental as anesthetic agents in electroconvulsive therapy: a retrospective study in major depression. Rev Psiquiatr Salud Ment. 2014;7(1):42-7.
Martínez-Amorós, E., Gálvez Ortiz, V., Porter Moli, M., Llorens Capdevila, M., Cerrillo Albaigés, E., Garcia-Parés, G., Cardoner Álvarez, N., & Urretavizcaya Sarachaga, M. (2014). Propofol and thiopental as anesthetic agents in electroconvulsive therapy: a retrospective study in major depression. Revista De Psiquiatria Y Salud Mental, 7(1), 42-7. https://doi.org/10.1016/j.rpsm.2013.01.002
Martínez-Amorós E, et al. Propofol and Thiopental as Anesthetic Agents in Electroconvulsive Therapy: a Retrospective Study in Major Depression. Rev Psiquiatr Salud Ment. 2014 Jan-Mar;7(1):42-7. PubMed PMID: 23490495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Propofol and thiopental as anesthetic agents in electroconvulsive therapy: a retrospective study in major depression. AU - Martínez-Amorós,Erika, AU - Gálvez Ortiz,Verònica, AU - Porter Moli,Montserrat, AU - Llorens Capdevila,Marta, AU - Cerrillo Albaigés,Ester, AU - Garcia-Parés,Gemma, AU - Cardoner Álvarez,Narcís, AU - Urretavizcaya Sarachaga,Mikel, Y1 - 2013/03/11/ PY - 2012/12/03/received PY - 2013/01/08/revised PY - 2013/01/22/accepted PY - 2013/3/16/entrez PY - 2013/3/16/pubmed PY - 2015/4/14/medline KW - Electroconvulsive therapy KW - Major depression KW - Pentotal KW - Propofol KW - Terapia electroconvulsiva KW - Thiopental KW - Trastorno depresivo mayor SP - 42 EP - 7 JF - Revista de psiquiatria y salud mental JO - Rev Psiquiatr Salud Ment VL - 7 IS - 1 N2 - OBJECTIVE: To determine the influence of propofol and thiopental as anesthetics in electroconvulsive therapy (ECT), as regards, seizure duration, electrical charge, clinical efficacy, cardiovascular profile, and presence of adverse cognitive effects. METHODS: A retrospective design including 127 patients who received bilateral ECT for the treatment of a major depressive episode. RESULTS: The mean seizure duration in the propofol group was significantly shorter than in the thiopental group (21.23±6.09 versus 28.24±6.6 7s, P<.001). The mean stimulus charge was 348.22 mC in the propofol group, and 238 mC in the thiopental group (P<.001). Propofol was associated with a lower increase in blood pressure. There were no differences between groups in treatment response or presence of adverse effects. CONCLUSIONS: The anesthetic agent used in ECT might determine differences in parameters such as seizure duration or electrical charge. However, this does not seem to be translated into differences in clinical efficacy or the pattern of adverse effects observed. SN - 1989-4600 UR - https://www.unboundmedicine.com/medline/citation/23490495/Propofol_and_thiopental_as_anesthetic_agents_in_electroconvulsive_therapy:_a_retrospective_study_in_major_depression_ L2 - https://www.elsevier.es/en/linksolver/pdf/pii/S1888-9891(13)00015-3 DB - PRIME DP - Unbound Medicine ER -