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Plasma selenium levels in Turkish women with polycystic ovary syndrome.
Eur J Obstet Gynecol Reprod Biol. 2013 Jun; 168(2):183-6.EJ

Abstract

OBJECTIVE(S)

To evaluate selenium (Se) levels in serum and their relation with hyperandrogenism and insulin resistance (IR) in women with polycystic ovary syndrome (PCOS) and in control subjects.

STUDY DESIGN

Women with any gynecological problem who presented to the Kahramanmaras Sutcuimam University Medical Faculty Gynecology and Obstetric Outpatient Clinic were invited to participate. Group 1 consisted of 36 cases with a diagnosis of PCOS according to the 2003 Rotterdam Consensus Criteria, and Group 2 (control group) consisted of 33 age- and BMI-matched healthy women. In all cases, serum total testosterone (tT), dihydroepiandrostenedione-sulfate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), insulin, glucose (mg/dL), total cholesterol (TC) (mg/dL), high density lipoprotein-cholesterol (HDL-C) (mg/dL), low density lipoprotein-cholesterol (LDL-C) (mg/dL), triglyceride (TG) (mg/dL) and Se levels were measured.

RESULTS

The level of FSH was significantly lower, and the levels of LH, E2, tT, and DHEAS were significantly higher in group 1 than in group 2 (p<0.05). The hirsutism score was significantly higher among PCOS women compared to the control group (p<0.05). Although insulin levels and HOMA-IR were markedly increased in the PCOS group compared to the control group, the differences were not significant (p>0.05). The plasma Se level was significantly lower in PCOS women compared to the control group (p<0.05). When we combined the all women in two groups, regarding them as one group (combined group, n=69), a negative correlation between Se and LH and tT was present (p<0.05).

CONCLUSION(S)

Our results show decreased plasma concentrations of Se and a negative correlation between Se and LH, tT in women with PCOS. These results indicate that Se may play a role in the pathogenesis of PCOS related with hyperandrogenism.

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Authors+Show Affiliations

Coskun A
Kahramanmaras Sutcuimam University Medical Faculty, Department of Obstetrics and Gynecology, Kahramanmaras, Turkey. drayhancoskun@hotmail.com
Arikan T
No affiliation info available
Kilinc M
No affiliation info available
Arikan DC
No affiliation info available
Ekerbiçer HÇ
No affiliation info available

MeSH

AdultBody Mass IndexCase-Control StudiesDehydroepiandrosterone SulfateDown-RegulationEstradiolFemaleFollicle Stimulating Hormone, HumanHirsutismHumansHyperandrogenismInsulin ResistanceLuteinizing HormoneOverweightPolycystic Ovary SyndromeSeleniumTestosteroneTurkeyUp-RegulationYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23490536

Citation

Coskun, Ayhan, et al. "Plasma Selenium Levels in Turkish Women With Polycystic Ovary Syndrome." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 168, no. 2, 2013, pp. 183-6.
Coskun A, Arikan T, Kilinc M, et al. Plasma selenium levels in Turkish women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2013;168(2):183-6.
Coskun, A., Arikan, T., Kilinc, M., Arikan, D. C., & Ekerbiçer, H. Ç. (2013). Plasma selenium levels in Turkish women with polycystic ovary syndrome. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 168(2), 183-6. https://doi.org/10.1016/j.ejogrb.2013.01.021
Coskun A, et al. Plasma Selenium Levels in Turkish Women With Polycystic Ovary Syndrome. Eur J Obstet Gynecol Reprod Biol. 2013;168(2):183-6. PubMed PMID: 23490536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma selenium levels in Turkish women with polycystic ovary syndrome. AU - Coskun,Ayhan, AU - Arikan,Tugba, AU - Kilinc,Metin, AU - Arikan,Deniz Cemgil, AU - Ekerbiçer,Hasan Çetin, Y1 - 2013/03/13/ PY - 2012/05/28/received PY - 2013/01/03/revised PY - 2013/01/23/accepted PY - 2013/3/16/entrez PY - 2013/3/16/pubmed PY - 2013/10/23/medline SP - 183 EP - 6 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 168 IS - 2 N2 - OBJECTIVE(S): To evaluate selenium (Se) levels in serum and their relation with hyperandrogenism and insulin resistance (IR) in women with polycystic ovary syndrome (PCOS) and in control subjects. STUDY DESIGN: Women with any gynecological problem who presented to the Kahramanmaras Sutcuimam University Medical Faculty Gynecology and Obstetric Outpatient Clinic were invited to participate. Group 1 consisted of 36 cases with a diagnosis of PCOS according to the 2003 Rotterdam Consensus Criteria, and Group 2 (control group) consisted of 33 age- and BMI-matched healthy women. In all cases, serum total testosterone (tT), dihydroepiandrostenedione-sulfate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), insulin, glucose (mg/dL), total cholesterol (TC) (mg/dL), high density lipoprotein-cholesterol (HDL-C) (mg/dL), low density lipoprotein-cholesterol (LDL-C) (mg/dL), triglyceride (TG) (mg/dL) and Se levels were measured. RESULTS: The level of FSH was significantly lower, and the levels of LH, E2, tT, and DHEAS were significantly higher in group 1 than in group 2 (p<0.05). The hirsutism score was significantly higher among PCOS women compared to the control group (p<0.05). Although insulin levels and HOMA-IR were markedly increased in the PCOS group compared to the control group, the differences were not significant (p>0.05). The plasma Se level was significantly lower in PCOS women compared to the control group (p<0.05). When we combined the all women in two groups, regarding them as one group (combined group, n=69), a negative correlation between Se and LH and tT was present (p<0.05). CONCLUSION(S): Our results show decreased plasma concentrations of Se and a negative correlation between Se and LH, tT in women with PCOS. These results indicate that Se may play a role in the pathogenesis of PCOS related with hyperandrogenism. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/23490536/Plasma_selenium_levels_in_Turkish_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(13)00064-X DB - PRIME DP - Unbound Medicine ER -