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Endocannabinoid system and drug addiction: new insights from mutant mice approaches.
Curr Opin Neurobiol 2013; 23(4):480-6CO

Abstract

The involvement of the endocannabinoid system in drug addiction was initially studied by the use of compounds with different affinities for each cannabinoid receptor or for the proteins involved in endocannabinoids inactivation. The generation of genetically modified mice with selective mutations in these endocannabinoid system components has now provided important advances in establishing their specific contribution to drug addiction. These genetic tools have identified the particular interest of CB1 cannabinoid receptor and endogenous anandamide as potential targets for drug addiction treatment. Novel genetic tools will allow determining if the modulation of CB2 cannabinoid receptor activity and 2-arachidonoylglycerol tone can also have an important therapeutic relevance for drug addiction.

Authors+Show Affiliations

Laboratory of Neuropharmacology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, C/Dr. Aiguader, 88, 08003 Barcelona, Spain. rafael.maldonado@upf.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23490550

Citation

Maldonado, Rafael, et al. "Endocannabinoid System and Drug Addiction: New Insights From Mutant Mice Approaches." Current Opinion in Neurobiology, vol. 23, no. 4, 2013, pp. 480-6.
Maldonado R, Robledo P, Berrendero F. Endocannabinoid system and drug addiction: new insights from mutant mice approaches. Curr Opin Neurobiol. 2013;23(4):480-6.
Maldonado, R., Robledo, P., & Berrendero, F. (2013). Endocannabinoid system and drug addiction: new insights from mutant mice approaches. Current Opinion in Neurobiology, 23(4), pp. 480-6. doi:10.1016/j.conb.2013.02.004.
Maldonado R, Robledo P, Berrendero F. Endocannabinoid System and Drug Addiction: New Insights From Mutant Mice Approaches. Curr Opin Neurobiol. 2013;23(4):480-6. PubMed PMID: 23490550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocannabinoid system and drug addiction: new insights from mutant mice approaches. AU - Maldonado,Rafael, AU - Robledo,Patricia, AU - Berrendero,Fernando, Y1 - 2013/03/13/ PY - 2012/12/21/received PY - 2013/01/14/revised PY - 2013/02/04/accepted PY - 2013/3/16/entrez PY - 2013/3/16/pubmed PY - 2014/2/28/medline SP - 480 EP - 6 JF - Current opinion in neurobiology JO - Curr. Opin. Neurobiol. VL - 23 IS - 4 N2 - The involvement of the endocannabinoid system in drug addiction was initially studied by the use of compounds with different affinities for each cannabinoid receptor or for the proteins involved in endocannabinoids inactivation. The generation of genetically modified mice with selective mutations in these endocannabinoid system components has now provided important advances in establishing their specific contribution to drug addiction. These genetic tools have identified the particular interest of CB1 cannabinoid receptor and endogenous anandamide as potential targets for drug addiction treatment. Novel genetic tools will allow determining if the modulation of CB2 cannabinoid receptor activity and 2-arachidonoylglycerol tone can also have an important therapeutic relevance for drug addiction. SN - 1873-6882 UR - https://www.unboundmedicine.com/medline/citation/23490550/Endocannabinoid_system_and_drug_addiction:_new_insights_from_mutant_mice_approaches_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-4388(13)00052-4 DB - PRIME DP - Unbound Medicine ER -