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Endocannabinoid system and drug addiction: new insights from mutant mice approaches.

Abstract

The involvement of the endocannabinoid system in drug addiction was initially studied by the use of compounds with different affinities for each cannabinoid receptor or for the proteins involved in endocannabinoids inactivation. The generation of genetically modified mice with selective mutations in these endocannabinoid system components has now provided important advances in establishing their specific contribution to drug addiction. These genetic tools have identified the particular interest of CB1 cannabinoid receptor and endogenous anandamide as potential targets for drug addiction treatment. Novel genetic tools will allow determining if the modulation of CB2 cannabinoid receptor activity and 2-arachidonoylglycerol tone can also have an important therapeutic relevance for drug addiction.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Laboratory of Neuropharmacology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, C/Dr. Aiguader, 88, 08003 Barcelona, Spain. rafael.maldonado@upf.edu

    ,

    Source

    Current opinion in neurobiology 23:4 2013 Aug pg 480-6

    MeSH

    Amidohydrolases
    Animals
    Disease Models, Animal
    Endocannabinoids
    Humans
    Mice
    Mice, Transgenic
    Monoacylglycerol Lipases
    Mutation
    Receptor, Cannabinoid, CB1
    Receptor, Cannabinoid, CB2
    Substance-Related Disorders

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23490550

    Citation

    Maldonado, Rafael, et al. "Endocannabinoid System and Drug Addiction: New Insights From Mutant Mice Approaches." Current Opinion in Neurobiology, vol. 23, no. 4, 2013, pp. 480-6.
    Maldonado R, Robledo P, Berrendero F. Endocannabinoid system and drug addiction: new insights from mutant mice approaches. Curr Opin Neurobiol. 2013;23(4):480-6.
    Maldonado, R., Robledo, P., & Berrendero, F. (2013). Endocannabinoid system and drug addiction: new insights from mutant mice approaches. Current Opinion in Neurobiology, 23(4), pp. 480-6. doi:10.1016/j.conb.2013.02.004.
    Maldonado R, Robledo P, Berrendero F. Endocannabinoid System and Drug Addiction: New Insights From Mutant Mice Approaches. Curr Opin Neurobiol. 2013;23(4):480-6. PubMed PMID: 23490550.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Endocannabinoid system and drug addiction: new insights from mutant mice approaches. AU - Maldonado,Rafael, AU - Robledo,Patricia, AU - Berrendero,Fernando, Y1 - 2013/03/13/ PY - 2012/12/21/received PY - 2013/01/14/revised PY - 2013/02/04/accepted PY - 2013/3/16/entrez PY - 2013/3/16/pubmed PY - 2014/2/28/medline SP - 480 EP - 6 JF - Current opinion in neurobiology JO - Curr. Opin. Neurobiol. VL - 23 IS - 4 N2 - The involvement of the endocannabinoid system in drug addiction was initially studied by the use of compounds with different affinities for each cannabinoid receptor or for the proteins involved in endocannabinoids inactivation. The generation of genetically modified mice with selective mutations in these endocannabinoid system components has now provided important advances in establishing their specific contribution to drug addiction. These genetic tools have identified the particular interest of CB1 cannabinoid receptor and endogenous anandamide as potential targets for drug addiction treatment. Novel genetic tools will allow determining if the modulation of CB2 cannabinoid receptor activity and 2-arachidonoylglycerol tone can also have an important therapeutic relevance for drug addiction. SN - 1873-6882 UR - https://www.unboundmedicine.com/medline/citation/23490550/Endocannabinoid_system_and_drug_addiction:_new_insights_from_mutant_mice_approaches_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-4388(13)00052-4 DB - PRIME DP - Unbound Medicine ER -