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Vitamin d and the risk of uterine fibroids.
Epidemiology 2013; 24(3):447-53E

Abstract

BACKGROUND

Uterine leiomyomata (also known as fibroids) are benign tumors of uterine smooth muscle that are characterized by overproduction of extracellular matrix. Fibroids are the leading indication for hysterectomy in the United States. The active metabolite of vitamin D has been shown to inhibit cell proliferation and extracellular matrix production in fibroid tissue culture and to reduce fibroid volume in the Eker rat. No previous study has examined whether vitamin D is related to fibroid status in women.

METHODS

The National Institute of Environmental Health Sciences Uterine Fibroid Study enrolled randomly selected 35- to 49-year-old women who were members of an urban health plan during 1996-1999. Fibroid status was determined by ultrasound screening of premenopausal women (620 blacks, 416 whites). Vitamin D status was assessed in stored plasma by radioimmunoassay of 25-hydroxyvitamin D (25(OH)D) and questionnaire data on sun exposure. Associations were evaluated with logistic regression, controlling for potential confounders.

RESULTS

Only 10% of blacks and 50% of whites had levels of 25(OH)D regarded as sufficient (>20 ng/ml). Women with sufficient vitamin D had an estimated 32% lower odds of fibroids compared with those with vitamin D insufficiency (adjusted odds ratio [aOR] = 0.68, 95% confidence interval [CI] = 0.48-0.96). The association was similar for blacks and whites. Self-reported sun exposure ≥ 1 hour per day (weather permitting) was also associated with reduced odds of fibroids (aOR = 06. [0.4-0.9]), with no evidence of heterogeneity by ethnicity.

CONCLUSIONS

The consistency of findings for questionnaire and biomarker data, the similar patterns seen in blacks and whites, and the biological plausibility provide evidence that sufficient vitamin D is associated with a reduced risk of uterine fibroids.

Authors+Show Affiliations

Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. baird@niehs.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

23493030

Citation

Baird, Donna Day, et al. "Vitamin D and the Risk of Uterine Fibroids." Epidemiology (Cambridge, Mass.), vol. 24, no. 3, 2013, pp. 447-53.
Baird DD, Hill MC, Schectman JM, et al. Vitamin d and the risk of uterine fibroids. Epidemiology. 2013;24(3):447-53.
Baird, D. D., Hill, M. C., Schectman, J. M., & Hollis, B. W. (2013). Vitamin d and the risk of uterine fibroids. Epidemiology (Cambridge, Mass.), 24(3), pp. 447-53. doi:10.1097/EDE.0b013e31828acca0.
Baird DD, et al. Vitamin D and the Risk of Uterine Fibroids. Epidemiology. 2013;24(3):447-53. PubMed PMID: 23493030.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin d and the risk of uterine fibroids. AU - Baird,Donna Day, AU - Hill,Michael C, AU - Schectman,Joel M, AU - Hollis,Bruce W, PY - 2013/3/16/entrez PY - 2013/3/16/pubmed PY - 2013/10/1/medline SP - 447 EP - 53 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 24 IS - 3 N2 - BACKGROUND: Uterine leiomyomata (also known as fibroids) are benign tumors of uterine smooth muscle that are characterized by overproduction of extracellular matrix. Fibroids are the leading indication for hysterectomy in the United States. The active metabolite of vitamin D has been shown to inhibit cell proliferation and extracellular matrix production in fibroid tissue culture and to reduce fibroid volume in the Eker rat. No previous study has examined whether vitamin D is related to fibroid status in women. METHODS: The National Institute of Environmental Health Sciences Uterine Fibroid Study enrolled randomly selected 35- to 49-year-old women who were members of an urban health plan during 1996-1999. Fibroid status was determined by ultrasound screening of premenopausal women (620 blacks, 416 whites). Vitamin D status was assessed in stored plasma by radioimmunoassay of 25-hydroxyvitamin D (25(OH)D) and questionnaire data on sun exposure. Associations were evaluated with logistic regression, controlling for potential confounders. RESULTS: Only 10% of blacks and 50% of whites had levels of 25(OH)D regarded as sufficient (>20 ng/ml). Women with sufficient vitamin D had an estimated 32% lower odds of fibroids compared with those with vitamin D insufficiency (adjusted odds ratio [aOR] = 0.68, 95% confidence interval [CI] = 0.48-0.96). The association was similar for blacks and whites. Self-reported sun exposure ≥ 1 hour per day (weather permitting) was also associated with reduced odds of fibroids (aOR = 06. [0.4-0.9]), with no evidence of heterogeneity by ethnicity. CONCLUSIONS: The consistency of findings for questionnaire and biomarker data, the similar patterns seen in blacks and whites, and the biological plausibility provide evidence that sufficient vitamin D is associated with a reduced risk of uterine fibroids. SN - 1531-5487 UR - https://www.unboundmedicine.com/medline/citation/23493030/Vitamin_d_and_the_risk_of_uterine_fibroids_ L2 - http://dx.doi.org/10.1097/EDE.0b013e31828acca0 DB - PRIME DP - Unbound Medicine ER -