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Obstructive sleep apnea during rapid eye movement sleep, daytime sleepiness, and quality of life in older men in Osteoporotic Fractures in Men (MrOS) Sleep Study.
J Clin Sleep Med. 2013 Mar 15; 9(3):191-8.JC

Abstract

STUDY OBJECTIVES

Assess the association between REM predominant obstructive sleep apnea (OSA), sleepiness, and quality of life in a community-based cohort of men ≥ 65 years-old. DESIGN INTERVENTION AND MEASUREMENTS: A cross-sectional analysis of 2,765 subjects from the Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study was performed to identify subjects with an apnea hypopnea index (AHI) < 15 (n = 2,044). Subjects were divided into groups based on the AHI in REM sleep (< 5 [referent group], 5 to < 15, 15 to < 30, and ≥ 30). Daytime somnolence, sleep-related quality of life, sleep disturbance, general quality of life, depressive symptoms, and health status were quantified using Epworth Sleepiness Scale (ESS), Functional Outcomes of Sleep Questionnaire (FOSQ), Pittsburgh Sleep Quality Index (PSQI), Short Form-12 (SF-12), Geriatric Depression Scale-15 (GDS), and self-perceived health status, respectively.

RESULTS

Prevalence of REM-predominant OSA (AHI-REM ≥ 5) was 42.8% if OSA was defined as AHI ≥ 15 and 14.4% if OSA was defined as AHI ≥ 5. Higher AHI-REM was associated with polysomnographic indices of poorer sleep architecture (reduced total sleep time, sleep efficiency, REM sleep duration and proportion). Adjusting for age, BMI, and study site, higher AHI-REM was not associated with subjective sleep measures (ESS, FOSQ, PSQI), lower quality of life (SF-12), or greater depressive symptoms (GDS).

CONCLUSIONS

In a community-based sample of older adult men ≥ 65 years-old, REM-predominant OSA was highly prevalent and was associated with objective indices of poorer sleep quality on polysomnography but not with subjective measures of daytime sleepiness or quality of life.

Authors+Show Affiliations

Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR 97239-3098, USA. khana@ohsu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23493839

Citation

Khan, Akram, et al. "Obstructive Sleep Apnea During Rapid Eye Movement Sleep, Daytime Sleepiness, and Quality of Life in Older Men in Osteoporotic Fractures in Men (MrOS) Sleep Study." Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine, vol. 9, no. 3, 2013, pp. 191-8.
Khan A, Harrison SL, Kezirian EJ, et al. Obstructive sleep apnea during rapid eye movement sleep, daytime sleepiness, and quality of life in older men in Osteoporotic Fractures in Men (MrOS) Sleep Study. J Clin Sleep Med. 2013;9(3):191-8.
Khan, A., Harrison, S. L., Kezirian, E. J., Ancoli-Israel, S., O'Hearn, D., Orwoll, E., Redline, S., Ensrud, K., & Stone, K. L. (2013). Obstructive sleep apnea during rapid eye movement sleep, daytime sleepiness, and quality of life in older men in Osteoporotic Fractures in Men (MrOS) Sleep Study. Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine, 9(3), 191-8. https://doi.org/10.5664/jcsm.2474
Khan A, et al. Obstructive Sleep Apnea During Rapid Eye Movement Sleep, Daytime Sleepiness, and Quality of Life in Older Men in Osteoporotic Fractures in Men (MrOS) Sleep Study. J Clin Sleep Med. 2013 Mar 15;9(3):191-8. PubMed PMID: 23493839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obstructive sleep apnea during rapid eye movement sleep, daytime sleepiness, and quality of life in older men in Osteoporotic Fractures in Men (MrOS) Sleep Study. AU - Khan,Akram, AU - Harrison,Stephanie L, AU - Kezirian,Eric J, AU - Ancoli-Israel,Sonia, AU - O'Hearn,Daniel, AU - Orwoll,Eric, AU - Redline,Susan, AU - Ensrud,Kristine, AU - Stone,Katie L, AU - ,, Y1 - 2013/03/15/ PY - 2012/02/06/received PY - 2012/06/10/revised PY - 2012/08/06/accepted PY - 2013/3/16/entrez PY - 2013/3/16/pubmed PY - 2013/9/17/medline KW - Sleep apnea syndromes KW - disorders of excessive somnolence KW - epidemiology KW - obstructive KW - older adults KW - quality of life KW - rapid eye movement KW - sleep KW - sleep apnea SP - 191 EP - 8 JF - Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine JO - J Clin Sleep Med VL - 9 IS - 3 N2 - STUDY OBJECTIVES: Assess the association between REM predominant obstructive sleep apnea (OSA), sleepiness, and quality of life in a community-based cohort of men ≥ 65 years-old. DESIGN INTERVENTION AND MEASUREMENTS: A cross-sectional analysis of 2,765 subjects from the Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study was performed to identify subjects with an apnea hypopnea index (AHI) < 15 (n = 2,044). Subjects were divided into groups based on the AHI in REM sleep (< 5 [referent group], 5 to < 15, 15 to < 30, and ≥ 30). Daytime somnolence, sleep-related quality of life, sleep disturbance, general quality of life, depressive symptoms, and health status were quantified using Epworth Sleepiness Scale (ESS), Functional Outcomes of Sleep Questionnaire (FOSQ), Pittsburgh Sleep Quality Index (PSQI), Short Form-12 (SF-12), Geriatric Depression Scale-15 (GDS), and self-perceived health status, respectively. RESULTS: Prevalence of REM-predominant OSA (AHI-REM ≥ 5) was 42.8% if OSA was defined as AHI ≥ 15 and 14.4% if OSA was defined as AHI ≥ 5. Higher AHI-REM was associated with polysomnographic indices of poorer sleep architecture (reduced total sleep time, sleep efficiency, REM sleep duration and proportion). Adjusting for age, BMI, and study site, higher AHI-REM was not associated with subjective sleep measures (ESS, FOSQ, PSQI), lower quality of life (SF-12), or greater depressive symptoms (GDS). CONCLUSIONS: In a community-based sample of older adult men ≥ 65 years-old, REM-predominant OSA was highly prevalent and was associated with objective indices of poorer sleep quality on polysomnography but not with subjective measures of daytime sleepiness or quality of life. SN - 1550-9397 UR - https://www.unboundmedicine.com/medline/citation/23493839/Obstructive_sleep_apnea_during_rapid_eye_movement_sleep_daytime_sleepiness_and_quality_of_life_in_older_men_in_Osteoporotic_Fractures_in_Men__MrOS__Sleep_Study_ L2 - https://doi.org/10.5664/jcsm.2474 DB - PRIME DP - Unbound Medicine ER -