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Chemical composition and in vitro biological activities of the essential oil of Vepris macrophylla (BAKER) I.VERD. endemic to Madagascar.
Chem Biodivers. 2013 Mar; 10(3):356-66.CB

Abstract

Vepris macrophylla is an evergreen tree occurring in sub-humid forest of Madagascar and traditionally used in the Island to treat several complaints as well as to prepare aromatic teas and alcoholic drinks. In the present work, the essential oil distilled from the leaves was analyzed for the first time by gas chromatography (GC-FID) and gas chromatography/mass spectrometry (GC/MS). The major compounds were citral (56.3%), i.e., mixture of neral (23.1%) and geranial (33.2%), citronellol (14.5%), and myrcene (8.3%). The essential oil exhibited antimicrobial activity against S. aureus, P. aeruginosa, and C. albicans as determined by vapor-diffusion assay, supporting the traditional use of the plant for preparing steam bath for the treatment of infectious diseases. The essential oil was evaluated for cytotoxic activity on human tumor cell lines by MTT (=3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay, showing inhibitory effects comparable to those of cisplatin, notably on MDA-MB 231 (human breast adenocarcinoma) and HCT116 (human colon carcinoma) cell lines. Finally, the essential oil was also subjected to screening for its antioxidant activity and the free radical scavenging capacity.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Maggi F
School of Pharmacy, University of Camerino, IT-62032 Camerino, Italy. filippo.maggi@unicam.it
Fortuné Randriana R
No affiliation info available
Rasoanaivo P
No affiliation info available
Nicoletti M
No affiliation info available
Quassinti L
No affiliation info available
Bramucci M
No affiliation info available
Lupidi G
No affiliation info available
Petrelli D
No affiliation info available
Vitali LA
No affiliation info available
Papa F
No affiliation info available
Vittori S
No affiliation info available

MeSH

Anti-Infective AgentsAntineoplastic AgentsAntioxidantsCandida albicansCell Line, TumorCell SurvivalGas Chromatography-Mass SpectrometryHCT116 CellsHumansMadagascarMicrobial Sensitivity TestsOils, VolatilePlant LeavesPseudomonas aeruginosaRutaceaeStaphylococcus aureus

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23495153

Citation

Maggi, Filippo, et al. "Chemical Composition and in Vitro Biological Activities of the Essential Oil of Vepris Macrophylla (BAKER) I.VERD. Endemic to Madagascar." Chemistry & Biodiversity, vol. 10, no. 3, 2013, pp. 356-66.
Maggi F, Fortuné Randriana R, Rasoanaivo P, et al. Chemical composition and in vitro biological activities of the essential oil of Vepris macrophylla (BAKER) I.VERD. endemic to Madagascar. Chem Biodivers. 2013;10(3):356-66.
Maggi, F., Fortuné Randriana, R., Rasoanaivo, P., Nicoletti, M., Quassinti, L., Bramucci, M., Lupidi, G., Petrelli, D., Vitali, L. A., Papa, F., & Vittori, S. (2013). Chemical composition and in vitro biological activities of the essential oil of Vepris macrophylla (BAKER) I.VERD. endemic to Madagascar. Chemistry & Biodiversity, 10(3), 356-66. https://doi.org/10.1002/cbdv.201200253
Maggi F, et al. Chemical Composition and in Vitro Biological Activities of the Essential Oil of Vepris Macrophylla (BAKER) I.VERD. Endemic to Madagascar. Chem Biodivers. 2013;10(3):356-66. PubMed PMID: 23495153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition and in vitro biological activities of the essential oil of Vepris macrophylla (BAKER) I.VERD. endemic to Madagascar. AU - Maggi,Filippo, AU - Fortuné Randriana,Richard, AU - Rasoanaivo,Philippe, AU - Nicoletti,Marcello, AU - Quassinti,Luana, AU - Bramucci,Massimo, AU - Lupidi,Giulio, AU - Petrelli,Dezemona, AU - Vitali,Luca A, AU - Papa,Fabrizio, AU - Vittori,Sauro, PY - 2012/07/20/received PY - 2013/3/16/entrez PY - 2013/3/16/pubmed PY - 2013/9/18/medline SP - 356 EP - 66 JF - Chemistry & biodiversity JO - Chem Biodivers VL - 10 IS - 3 N2 - Vepris macrophylla is an evergreen tree occurring in sub-humid forest of Madagascar and traditionally used in the Island to treat several complaints as well as to prepare aromatic teas and alcoholic drinks. In the present work, the essential oil distilled from the leaves was analyzed for the first time by gas chromatography (GC-FID) and gas chromatography/mass spectrometry (GC/MS). The major compounds were citral (56.3%), i.e., mixture of neral (23.1%) and geranial (33.2%), citronellol (14.5%), and myrcene (8.3%). The essential oil exhibited antimicrobial activity against S. aureus, P. aeruginosa, and C. albicans as determined by vapor-diffusion assay, supporting the traditional use of the plant for preparing steam bath for the treatment of infectious diseases. The essential oil was evaluated for cytotoxic activity on human tumor cell lines by MTT (=3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay, showing inhibitory effects comparable to those of cisplatin, notably on MDA-MB 231 (human breast adenocarcinoma) and HCT116 (human colon carcinoma) cell lines. Finally, the essential oil was also subjected to screening for its antioxidant activity and the free radical scavenging capacity. SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/23495153/Chemical_composition_and_in_vitro_biological_activities_of_the_essential_oil_of_Vepris_macrophylla__BAKER__I_VERD__endemic_to_Madagascar_ DB - PRIME DP - Unbound Medicine ER -