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Effectiveness of the trivalent influenza vaccine in Navarre, Spain, 2010-2011: a population-based test-negative case-control study.
BMC Public Health 2013; 13:191BP

Abstract

BACKGROUND

Some studies have evaluated vaccine effectiveness in preventing outpatient influenza while others have analysed its effectiveness in preventing hospitalizations. This study evaluates the effectiveness of the trivalent influenza vaccine in preventing outpatient illness and hospitalizations from laboratory-confirmed influenza in the 2010-2011 season.

METHODS

We conducted a nested case-control study in the population covered by the general practitioner sentinel network for influenza surveillance in Navarre, Spain. Patients with influenza-like illness in hospitals and primary health care were swabbed for influenza testing. Influenza vaccination status and other covariates were obtained from health care databases. Using logistic regression, the vaccination status of laboratory-confirmed influenza cases was compared with that of test-negative controls, adjusting for age, sex, comorbidity, outpatient visits in the previous 12 months, health care setting, time between symptom onset and swabbing, period and A(H1N1)pdm09 vaccination. Effectiveness was calculated as (1-odds ratio)x100.

RESULTS

The 303 confirmed influenza cases (88% for A(H1N1)pdm09 influenza) were compared with the 286 influenza test-negative controls. The percentage of persons vaccinated against influenza was 4.3% and 15.7%, respectively (p<0.001). The adjusted estimate of effectiveness was 67% (95% CI: 24%, 86%) for all patients and 64% (95% CI: 8%, 86%) in those with an indication for vaccination (persons age 60 or older or with major chronic conditions). Having received both the 2010-2011 seasonal influenza vaccine and the 2009-2010 pandemic influenza vaccine provided 87% protection (95% CI: 30%, 98%) as compared to those not vaccinated.

CONCLUSION

The 2010-2011 seasonal influenza vaccine had a moderate protective effect in preventing laboratory-confirmed influenza.

Authors+Show Affiliations

Instituto de Salud Pública de Navarra, Leyre 15, 31003, Pamplona, Spain. imartinba@navarra.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23496887

Citation

Martínez-Baz, Iván, et al. "Effectiveness of the Trivalent Influenza Vaccine in Navarre, Spain, 2010-2011: a Population-based Test-negative Case-control Study." BMC Public Health, vol. 13, 2013, p. 191.
Martínez-Baz I, Martínez-Artola V, Reina G, et al. Effectiveness of the trivalent influenza vaccine in Navarre, Spain, 2010-2011: a population-based test-negative case-control study. BMC Public Health. 2013;13:191.
Martínez-Baz, I., Martínez-Artola, V., Reina, G., Guevara, M., Cenoz, M. G., Morán, J., ... Castilla, J. (2013). Effectiveness of the trivalent influenza vaccine in Navarre, Spain, 2010-2011: a population-based test-negative case-control study. BMC Public Health, 13, p. 191. doi:10.1186/1471-2458-13-191.
Martínez-Baz I, et al. Effectiveness of the Trivalent Influenza Vaccine in Navarre, Spain, 2010-2011: a Population-based Test-negative Case-control Study. BMC Public Health. 2013 Mar 6;13:191. PubMed PMID: 23496887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of the trivalent influenza vaccine in Navarre, Spain, 2010-2011: a population-based test-negative case-control study. AU - Martínez-Baz,Iván, AU - Martínez-Artola,Víctor, AU - Reina,Gabriel, AU - Guevara,Marcela, AU - Cenoz,Manuel García, AU - Morán,Julio, AU - Irisarri,Fátima, AU - Arriazu,Maite, AU - Albeniz,Esther, AU - Castilla,Jesús, AU - ,, Y1 - 2013/03/06/ PY - 2012/04/05/received PY - 2013/02/28/accepted PY - 2013/3/19/entrez PY - 2013/3/19/pubmed PY - 2013/7/25/medline SP - 191 EP - 191 JF - BMC public health JO - BMC Public Health VL - 13 N2 - BACKGROUND: Some studies have evaluated vaccine effectiveness in preventing outpatient influenza while others have analysed its effectiveness in preventing hospitalizations. This study evaluates the effectiveness of the trivalent influenza vaccine in preventing outpatient illness and hospitalizations from laboratory-confirmed influenza in the 2010-2011 season. METHODS: We conducted a nested case-control study in the population covered by the general practitioner sentinel network for influenza surveillance in Navarre, Spain. Patients with influenza-like illness in hospitals and primary health care were swabbed for influenza testing. Influenza vaccination status and other covariates were obtained from health care databases. Using logistic regression, the vaccination status of laboratory-confirmed influenza cases was compared with that of test-negative controls, adjusting for age, sex, comorbidity, outpatient visits in the previous 12 months, health care setting, time between symptom onset and swabbing, period and A(H1N1)pdm09 vaccination. Effectiveness was calculated as (1-odds ratio)x100. RESULTS: The 303 confirmed influenza cases (88% for A(H1N1)pdm09 influenza) were compared with the 286 influenza test-negative controls. The percentage of persons vaccinated against influenza was 4.3% and 15.7%, respectively (p<0.001). The adjusted estimate of effectiveness was 67% (95% CI: 24%, 86%) for all patients and 64% (95% CI: 8%, 86%) in those with an indication for vaccination (persons age 60 or older or with major chronic conditions). Having received both the 2010-2011 seasonal influenza vaccine and the 2009-2010 pandemic influenza vaccine provided 87% protection (95% CI: 30%, 98%) as compared to those not vaccinated. CONCLUSION: The 2010-2011 seasonal influenza vaccine had a moderate protective effect in preventing laboratory-confirmed influenza. SN - 1471-2458 UR - https://www.unboundmedicine.com/medline/citation/23496887/Effectiveness_of_the_trivalent_influenza_vaccine_in_Navarre_Spain_2010_2011:_a_population_based_test_negative_case_control_study_ L2 - https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-13-191 DB - PRIME DP - Unbound Medicine ER -