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Serum homocysteine and methylmalonic acid concentrations in Chinese Shar-Pei dogs with cobalamin deficiency.
Vet J. 2013 Aug; 197(2):420-6.VJ

Abstract

Cobalamin deficiency is suspected to be hereditary in Chinese Shar-Pei dogs (Shar-Peis), and inherited causes of cobalamin deficiency may affect the cellular processing of cobalamin. In humans, a defect of the two main cobalamin-dependent intracellular enzymes (i.e., methionine synthase and methylmalonyl-CoA mutase) may lead to hyperhomocysteinemia and hypermethylmalonic acidemia. The aim of this retrospective study was to evaluate serum homocysteine (HCY) and methylmalonic acid (MMA) concentrations in cobalamin-deficient Shar-Peis and dogs of six other breeds. Serum samples (n=297) from cobalamin-deficient dogs (Shar-Peis, German Shepherd dogs, Labrador Retrievers, Yorkshire Terriers, Boxers, Cocker Spaniels, and Beagles) were analyzed for serum HCY and MMA concentrations. A Fisher's exact test was used to evaluate if cobalamin deficiency in Shar-Peis is associated with hyperhomocysteinemia. Serum HCY and MMA concentrations were higher in cobalamin-deficient Shar-Peis compared to cobalamin-deficient dogs of the six other breeds (P<0.0001). Hyperhomocysteinemia was associated with cobalamin deficiency in Shar-Peis (P=0.009). In addition, serum HCY and MMA concentrations did not differ between cobalamin-deficient German Shepherd dogs with and without exocrine pancreatic insufficiency (EPI), a potential cause of secondary cobalamin deficiency. These findings suggest that the function of the two intracellular cobalamin-dependent enzymes is impaired in Shar-Peis with cobalamin deficiency.

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Authors+Show Affiliations

Grützner N
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4474, USA. ngruetzner@cvm.tamu.edu
Heilmann RM
No affiliation info available
Stupka KC
No affiliation info available
Rangachari VR
No affiliation info available
Weber K
No affiliation info available
Holzenburg A
No affiliation info available
Suchodolski JS
No affiliation info available
Steiner JM
No affiliation info available

MeSH

AnimalsDog DiseasesDogsGenetic Predisposition to DiseaseHomocysteineMethylmalonic AcidRetrospective StudiesVitamin B 12 Deficiency

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23499543

Citation

Grützner, Niels, et al. "Serum Homocysteine and Methylmalonic Acid Concentrations in Chinese Shar-Pei Dogs With Cobalamin Deficiency." Veterinary Journal (London, England : 1997), vol. 197, no. 2, 2013, pp. 420-6.
Grützner N, Heilmann RM, Stupka KC, et al. Serum homocysteine and methylmalonic acid concentrations in Chinese Shar-Pei dogs with cobalamin deficiency. Vet J. 2013;197(2):420-6.
Grützner, N., Heilmann, R. M., Stupka, K. C., Rangachari, V. R., Weber, K., Holzenburg, A., Suchodolski, J. S., & Steiner, J. M. (2013). Serum homocysteine and methylmalonic acid concentrations in Chinese Shar-Pei dogs with cobalamin deficiency. Veterinary Journal (London, England : 1997), 197(2), 420-6. https://doi.org/10.1016/j.tvjl.2013.02.002
Grützner N, et al. Serum Homocysteine and Methylmalonic Acid Concentrations in Chinese Shar-Pei Dogs With Cobalamin Deficiency. Vet J. 2013;197(2):420-6. PubMed PMID: 23499543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum homocysteine and methylmalonic acid concentrations in Chinese Shar-Pei dogs with cobalamin deficiency. AU - Grützner,Niels, AU - Heilmann,Romy M, AU - Stupka,Kenneth C, AU - Rangachari,Venkat R, AU - Weber,Katja, AU - Holzenburg,Andreas, AU - Suchodolski,Jan S, AU - Steiner,Jörg M, Y1 - 2013/03/15/ PY - 2012/08/21/received PY - 2012/12/21/revised PY - 2013/02/04/accepted PY - 2013/3/19/entrez PY - 2013/3/19/pubmed PY - 2014/2/7/medline KW - Cobalamin KW - Deficiency KW - Homocysteine KW - Methylmalonic acid KW - Shar-Pei dog SP - 420 EP - 6 JF - Veterinary journal (London, England : 1997) JO - Vet J VL - 197 IS - 2 N2 - Cobalamin deficiency is suspected to be hereditary in Chinese Shar-Pei dogs (Shar-Peis), and inherited causes of cobalamin deficiency may affect the cellular processing of cobalamin. In humans, a defect of the two main cobalamin-dependent intracellular enzymes (i.e., methionine synthase and methylmalonyl-CoA mutase) may lead to hyperhomocysteinemia and hypermethylmalonic acidemia. The aim of this retrospective study was to evaluate serum homocysteine (HCY) and methylmalonic acid (MMA) concentrations in cobalamin-deficient Shar-Peis and dogs of six other breeds. Serum samples (n=297) from cobalamin-deficient dogs (Shar-Peis, German Shepherd dogs, Labrador Retrievers, Yorkshire Terriers, Boxers, Cocker Spaniels, and Beagles) were analyzed for serum HCY and MMA concentrations. A Fisher's exact test was used to evaluate if cobalamin deficiency in Shar-Peis is associated with hyperhomocysteinemia. Serum HCY and MMA concentrations were higher in cobalamin-deficient Shar-Peis compared to cobalamin-deficient dogs of the six other breeds (P<0.0001). Hyperhomocysteinemia was associated with cobalamin deficiency in Shar-Peis (P=0.009). In addition, serum HCY and MMA concentrations did not differ between cobalamin-deficient German Shepherd dogs with and without exocrine pancreatic insufficiency (EPI), a potential cause of secondary cobalamin deficiency. These findings suggest that the function of the two intracellular cobalamin-dependent enzymes is impaired in Shar-Peis with cobalamin deficiency. SN - 1532-2971 UR - https://www.unboundmedicine.com/medline/citation/23499543/Serum_homocysteine_and_methylmalonic_acid_concentrations_in_Chinese_Shar_Pei_dogs_with_cobalamin_deficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-0233(13)00064-6 DB - PRIME DP - Unbound Medicine ER -