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[First occurrence of an organic manic schizophreniform syndrome followed by catatonia induced by anti-NMDA-receptor encephalitis].
Fortschr Neurol Psychiatr. 2013 Apr; 81(4):206-9.FN

Abstract

We report on a 39-year-old female patient who developed catatonia after there had been schizomanic symptoms in the six months before. At admission the patient exhibited catatonia, a tetraspastic syndrome and focal epileptic seizures. The cranial MRI revealed bilateral subcortical hyperintense lesions which took up contrast agent. Examination of the cerebrospinal fluid disclosed a lymphocytic pleocytosis and autochthone oligoclonal bands. In the serum autoantibodies against the NMDA-NR-1 receptor were reproducibly detected. A detailed search for a tumour was negative. In detail, we could exclude a neoplasm of the ovaries which is often present in the paraneoplastic type of anti-NMDA-receptor encephalitis. Therefore we assume an autoimmune, not paraneoplastic, encephalitis in our patient. The symptoms improved significantly after an immunosuppressive therapy - initially with glucocorticoids followed by rituximab - had been initiated. This case illustrates that an autoimmune encephalitis should be looked for when first psychotic symptoms occur.

Authors+Show Affiliations

Klinik für Neurologie, Universitätsklinikum des Saarlands, 66421 Homburg.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ger

PubMed ID

23504517

Citation

Fousse, M, et al. "[First Occurrence of an Organic Manic Schizophreniform Syndrome Followed By Catatonia Induced By anti-NMDA-receptor Encephalitis]." Fortschritte Der Neurologie-Psychiatrie, vol. 81, no. 4, 2013, pp. 206-9.
Fousse M, Becker C, Faβbender K, et al. [First occurrence of an organic manic schizophreniform syndrome followed by catatonia induced by anti-NMDA-receptor encephalitis]. Fortschr Neurol Psychiatr. 2013;81(4):206-9.
Fousse, M., Becker, C., Faβbender, K., Reith, W., Körner, H., Alexandrou, M., & Spiegel, J. (2013). [First occurrence of an organic manic schizophreniform syndrome followed by catatonia induced by anti-NMDA-receptor encephalitis]. Fortschritte Der Neurologie-Psychiatrie, 81(4), 206-9. https://doi.org/10.1055/s-0033-1335044
Fousse M, et al. [First Occurrence of an Organic Manic Schizophreniform Syndrome Followed By Catatonia Induced By anti-NMDA-receptor Encephalitis]. Fortschr Neurol Psychiatr. 2013;81(4):206-9. PubMed PMID: 23504517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [First occurrence of an organic manic schizophreniform syndrome followed by catatonia induced by anti-NMDA-receptor encephalitis]. AU - Fousse,M, AU - Becker,C, AU - Faβbender,K, AU - Reith,W, AU - Körner,H, AU - Alexandrou,M, AU - Spiegel,J, Y1 - 2013/03/15/ PY - 2013/3/19/entrez PY - 2013/3/19/pubmed PY - 2013/10/29/medline SP - 206 EP - 9 JF - Fortschritte der Neurologie-Psychiatrie JO - Fortschr Neurol Psychiatr VL - 81 IS - 4 N2 - We report on a 39-year-old female patient who developed catatonia after there had been schizomanic symptoms in the six months before. At admission the patient exhibited catatonia, a tetraspastic syndrome and focal epileptic seizures. The cranial MRI revealed bilateral subcortical hyperintense lesions which took up contrast agent. Examination of the cerebrospinal fluid disclosed a lymphocytic pleocytosis and autochthone oligoclonal bands. In the serum autoantibodies against the NMDA-NR-1 receptor were reproducibly detected. A detailed search for a tumour was negative. In detail, we could exclude a neoplasm of the ovaries which is often present in the paraneoplastic type of anti-NMDA-receptor encephalitis. Therefore we assume an autoimmune, not paraneoplastic, encephalitis in our patient. The symptoms improved significantly after an immunosuppressive therapy - initially with glucocorticoids followed by rituximab - had been initiated. This case illustrates that an autoimmune encephalitis should be looked for when first psychotic symptoms occur. SN - 1439-3522 UR - https://www.unboundmedicine.com/medline/citation/23504517/[First_occurrence_of_an_organic_manic_schizophreniform_syndrome_followed_by_catatonia_induced_by_anti_NMDA_receptor_encephalitis]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0033-1335044 DB - PRIME DP - Unbound Medicine ER -