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Antidiabetic activity of Ficus amplissima Smith. bark extract in streptozotocin induced diabetic rats.
J Ethnopharmacol. 2013 May 20; 147(2):302-10.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Ficus amplissima commonly known as kal-itchchi have a long history of use in Ayurveda, Siddha and Unani herbal preparations in Indian traditional system of medicine. It has been used in folklore medicine for the treatment of diabetes.

AIM

The aim of the present study was to evaluate the effect of methanolic extract of the bark of Ficus amplissima (FAB) in streptozotocin-induced diabetic rats.

MATERIALS AND METHODS

Oral administration of FAB bark at the doses of 50mg/kg, 100mg/kg and 150 mg/kg was studied in normal, glucose-loaded and STZ-induced diabetic rats.

RESULTS

The three doses caused significant reduction in blood glucose levels in all the models. The effect was more pronounced in 50mg/kg and 100mg/kg than 150 mg/kg. FAB also showed significant increase in serum insulin and body weight. The glycogen content in liver, skeletal muscle, total protein contents were markedly increased and marker enzymes of hepatic function of STZ-induced diabetic rats while there was significant reduction in the levels of serum triglyceride and total cholesterol. FAB also showed significant anti-lipid peroxidative effect in the pancreas of STZ-induced diabetic rats. The anti-diabetic effect of FAB was compared with glibenclamide, a well known hypoglycemic drug. Histological analysis showed the regenerative effect of FAB on the β-cells of diabetic rats.

CONCLUSION

Results of this experimental study indicated that FAB possessed anti-diabetic and antioxidant activities. Hence it could be used as a natural source of antidiabetic (Type-I) and antioxidant drug.

Authors+Show Affiliations

Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India. arunachalam04@gmail.comNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23506985

Citation

Arunachalam, Karuppusamy, and Thangaraj Parimelazhagan. "Antidiabetic Activity of Ficus Amplissima Smith. Bark Extract in Streptozotocin Induced Diabetic Rats." Journal of Ethnopharmacology, vol. 147, no. 2, 2013, pp. 302-10.
Arunachalam K, Parimelazhagan T. Antidiabetic activity of Ficus amplissima Smith. bark extract in streptozotocin induced diabetic rats. J Ethnopharmacol. 2013;147(2):302-10.
Arunachalam, K., & Parimelazhagan, T. (2013). Antidiabetic activity of Ficus amplissima Smith. bark extract in streptozotocin induced diabetic rats. Journal of Ethnopharmacology, 147(2), 302-10. https://doi.org/10.1016/j.jep.2013.03.004
Arunachalam K, Parimelazhagan T. Antidiabetic Activity of Ficus Amplissima Smith. Bark Extract in Streptozotocin Induced Diabetic Rats. J Ethnopharmacol. 2013 May 20;147(2):302-10. PubMed PMID: 23506985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic activity of Ficus amplissima Smith. bark extract in streptozotocin induced diabetic rats. AU - Arunachalam,Karuppusamy, AU - Parimelazhagan,Thangaraj, Y1 - 2013/03/15/ PY - 2012/09/18/received PY - 2013/01/11/revised PY - 2013/03/02/accepted PY - 2013/3/20/entrez PY - 2013/3/20/pubmed PY - 2013/10/24/medline SP - 302 EP - 10 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 147 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Ficus amplissima commonly known as kal-itchchi have a long history of use in Ayurveda, Siddha and Unani herbal preparations in Indian traditional system of medicine. It has been used in folklore medicine for the treatment of diabetes. AIM: The aim of the present study was to evaluate the effect of methanolic extract of the bark of Ficus amplissima (FAB) in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Oral administration of FAB bark at the doses of 50mg/kg, 100mg/kg and 150 mg/kg was studied in normal, glucose-loaded and STZ-induced diabetic rats. RESULTS: The three doses caused significant reduction in blood glucose levels in all the models. The effect was more pronounced in 50mg/kg and 100mg/kg than 150 mg/kg. FAB also showed significant increase in serum insulin and body weight. The glycogen content in liver, skeletal muscle, total protein contents were markedly increased and marker enzymes of hepatic function of STZ-induced diabetic rats while there was significant reduction in the levels of serum triglyceride and total cholesterol. FAB also showed significant anti-lipid peroxidative effect in the pancreas of STZ-induced diabetic rats. The anti-diabetic effect of FAB was compared with glibenclamide, a well known hypoglycemic drug. Histological analysis showed the regenerative effect of FAB on the β-cells of diabetic rats. CONCLUSION: Results of this experimental study indicated that FAB possessed anti-diabetic and antioxidant activities. Hence it could be used as a natural source of antidiabetic (Type-I) and antioxidant drug. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/23506985/Antidiabetic_activity_of_Ficus_amplissima_Smith__bark_extract_in_streptozotocin_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(13)00147-5 DB - PRIME DP - Unbound Medicine ER -