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Hepatitis E virus infection.
Curr Opin Gastroenterol. 2013 May; 29(3):271-8.CO

Abstract

PURPOSE OF REVIEW

The spectrum of hepatitis E virus (HEV) infection has changed over the past 2 years, especially in the developed world. Herein, we review the progress made in studying the epidemiology, hepatic, and extrahepatic manifestations, and the treatment of HEV infection, over the past 2 years.

RECENT FINDINGS

HEV infection is an underdiagnosed disease because of the use of low-sensitivity serological assays. In addition to the four known genotypes, other new genotypes have also been recently described. HEV infection is not only a self-limiting disease but it can also evolve to chronic hepatitis and cirrhosis in organ transplant patients, hematological patients receiving chemotherapy, and HIV patients. HEV can also cause extrahepatic manifestations, such as neurological symptoms, kidney injury, and hematological disorders. Pegylated interferon and ribavirin have been found to effectively treat HEV infection.

SUMMARY

HEV is a worldwide disease that can cause hepatic and extrahepatic manifestations.

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Authors+Show Affiliations

Kamar N
Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France. kamar.n@chu-toulouse.fr
Izopet J
No affiliation info available
Rostaing L
No affiliation info available

MeSH

Chronic DiseaseDeveloped CountriesDeveloping CountriesHIV InfectionsHematologic DiseasesHepatitis EHumansOpportunistic InfectionsOrgan Transplantation

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23507918

Citation

Kamar, Nassim, et al. "Hepatitis E Virus Infection." Current Opinion in Gastroenterology, vol. 29, no. 3, 2013, pp. 271-8.
Kamar N, Izopet J, Rostaing L. Hepatitis E virus infection. Curr Opin Gastroenterol. 2013;29(3):271-8.
Kamar, N., Izopet, J., & Rostaing, L. (2013). Hepatitis E virus infection. Current Opinion in Gastroenterology, 29(3), 271-8. https://doi.org/10.1097/MOG.0b013e32835ff238
Kamar N, Izopet J, Rostaing L. Hepatitis E Virus Infection. Curr Opin Gastroenterol. 2013;29(3):271-8. PubMed PMID: 23507918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis E virus infection. AU - Kamar,Nassim, AU - Izopet,Jacques, AU - Rostaing,Lionel, PY - 2013/3/20/entrez PY - 2013/3/20/pubmed PY - 2013/9/26/medline SP - 271 EP - 8 JF - Current opinion in gastroenterology JO - Curr Opin Gastroenterol VL - 29 IS - 3 N2 - PURPOSE OF REVIEW: The spectrum of hepatitis E virus (HEV) infection has changed over the past 2 years, especially in the developed world. Herein, we review the progress made in studying the epidemiology, hepatic, and extrahepatic manifestations, and the treatment of HEV infection, over the past 2 years. RECENT FINDINGS: HEV infection is an underdiagnosed disease because of the use of low-sensitivity serological assays. In addition to the four known genotypes, other new genotypes have also been recently described. HEV infection is not only a self-limiting disease but it can also evolve to chronic hepatitis and cirrhosis in organ transplant patients, hematological patients receiving chemotherapy, and HIV patients. HEV can also cause extrahepatic manifestations, such as neurological symptoms, kidney injury, and hematological disorders. Pegylated interferon and ribavirin have been found to effectively treat HEV infection. SUMMARY: HEV is a worldwide disease that can cause hepatic and extrahepatic manifestations. SN - 1531-7056 UR - https://www.unboundmedicine.com/medline/citation/23507918/Hepatitis_E_virus_infection_ L2 - https://doi.org/10.1097/MOG.0b013e32835ff238 DB - PRIME DP - Unbound Medicine ER -