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Serum folate and vitamin B12 concentrations in relation to prostate cancer risk--a Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohort.
Int J Epidemiol. 2013 Feb; 42(1):201-10.IJ

Abstract

BACKGROUND

Although individual studies have been inconsistent, meta-analyses of epidemiological data suggest that high folate and vitamin B12 levels may be associated with increased prostate cancer risk.

METHODS

Within JANUS, a prospective cohort in Norway (n = 317 000) with baseline serum samples, we conducted a nested case-control study among 3000 prostate cancer cases and 3000 controls, matched on age and time at serum sampling, and county of residence. Using conditional logistic regression, odds ratios (OR) and 95% confidence intervals (CI) for prostate cancer risk were estimated according to quintiles of serum folate, vitamin B12, methylmalonic acid (MMA), total homocysteine (tHcy) and methionine, and according to MTHFR 677C→T genotypes. To correct for degradation during sample storage, folate concentration was measured as p-aminobenzoylglutamate (pABG) equivalents following oxidation and acid hydrolysis.

RESULTS

We observed a weak positive association between folate concentration and prostate cancer risk [OR highest vs lowest quintile = 1.15 (0.97-1.37), P-trend = 0.04], which was more pronounced among individuals ≥ 50 years at inclusion [OR 1.40 (1.07-1.84), P-trend = 0.02]. tHcy showed an inverse trend with risk [OR 0.92 (0.77-1.10), P-trend = 0.03]. Vitamin B12, MMA and methionine concentrations were not associated with prostate cancer risk. Compared with the MTHFR 677CC genotype, the CT and TT variants, both of which were related to lower folate concentrations, were associated with reduced prostate cancer risk [OR 0.82 (0.72-0.94) and OR 0.78 (0.64-0.94), respectively].

CONCLUSION

This large-scale population-based study suggests that high serum folate concentration may be associated with modestly increased prostate cancer risk. We did not observe an association between vitamin B12 status and prostate cancer risk.

Authors+Show Affiliations

Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway. Stefan.Vogel@isf.uib.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23508410

Citation

de Vogel, Stefan, et al. "Serum Folate and Vitamin B12 Concentrations in Relation to Prostate Cancer Risk--a Norwegian Population-based Nested Case-control Study of 3000 Cases and 3000 Controls Within the JANUS Cohort." International Journal of Epidemiology, vol. 42, no. 1, 2013, pp. 201-10.
de Vogel S, Meyer K, Fredriksen Å, et al. Serum folate and vitamin B12 concentrations in relation to prostate cancer risk--a Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohort. Int J Epidemiol. 2013;42(1):201-10.
de Vogel, S., Meyer, K., Fredriksen, Å., Ulvik, A., Ueland, P. M., Nygård, O., Vollset, S. E., Tell, G. S., Tretli, S., & Bjørge, T. (2013). Serum folate and vitamin B12 concentrations in relation to prostate cancer risk--a Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohort. International Journal of Epidemiology, 42(1), 201-10. https://doi.org/10.1093/ije/dys199
de Vogel S, et al. Serum Folate and Vitamin B12 Concentrations in Relation to Prostate Cancer Risk--a Norwegian Population-based Nested Case-control Study of 3000 Cases and 3000 Controls Within the JANUS Cohort. Int J Epidemiol. 2013;42(1):201-10. PubMed PMID: 23508410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum folate and vitamin B12 concentrations in relation to prostate cancer risk--a Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohort. AU - de Vogel,Stefan, AU - Meyer,Klaus, AU - Fredriksen,Åse, AU - Ulvik,Arve, AU - Ueland,Per Magne, AU - Nygård,Ottar, AU - Vollset,Stein Emil, AU - Tell,Grethe S, AU - Tretli,Steinar, AU - Bjørge,Tone, PY - 2013/3/20/entrez PY - 2013/3/20/pubmed PY - 2013/9/24/medline SP - 201 EP - 10 JF - International journal of epidemiology JO - Int J Epidemiol VL - 42 IS - 1 N2 - BACKGROUND: Although individual studies have been inconsistent, meta-analyses of epidemiological data suggest that high folate and vitamin B12 levels may be associated with increased prostate cancer risk. METHODS: Within JANUS, a prospective cohort in Norway (n = 317 000) with baseline serum samples, we conducted a nested case-control study among 3000 prostate cancer cases and 3000 controls, matched on age and time at serum sampling, and county of residence. Using conditional logistic regression, odds ratios (OR) and 95% confidence intervals (CI) for prostate cancer risk were estimated according to quintiles of serum folate, vitamin B12, methylmalonic acid (MMA), total homocysteine (tHcy) and methionine, and according to MTHFR 677C→T genotypes. To correct for degradation during sample storage, folate concentration was measured as p-aminobenzoylglutamate (pABG) equivalents following oxidation and acid hydrolysis. RESULTS: We observed a weak positive association between folate concentration and prostate cancer risk [OR highest vs lowest quintile = 1.15 (0.97-1.37), P-trend = 0.04], which was more pronounced among individuals ≥ 50 years at inclusion [OR 1.40 (1.07-1.84), P-trend = 0.02]. tHcy showed an inverse trend with risk [OR 0.92 (0.77-1.10), P-trend = 0.03]. Vitamin B12, MMA and methionine concentrations were not associated with prostate cancer risk. Compared with the MTHFR 677CC genotype, the CT and TT variants, both of which were related to lower folate concentrations, were associated with reduced prostate cancer risk [OR 0.82 (0.72-0.94) and OR 0.78 (0.64-0.94), respectively]. CONCLUSION: This large-scale population-based study suggests that high serum folate concentration may be associated with modestly increased prostate cancer risk. We did not observe an association between vitamin B12 status and prostate cancer risk. SN - 1464-3685 UR - https://www.unboundmedicine.com/medline/citation/23508410/Serum_folate_and_vitamin_B12_concentrations_in_relation_to_prostate_cancer_risk__a_Norwegian_population_based_nested_case_control_study_of_3000_cases_and_3000_controls_within_the_JANUS_cohort_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dys199 DB - PRIME DP - Unbound Medicine ER -